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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 7 of 7

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Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart.
Stroud DM, Yang T, Bersell K, Kryshtal DO, Nagao S, Shaffer C, Short L, Hall L, Atack TC, Zhang W, Knollmann BC, Baudenbacher F, Roden DM
(2016) J Am Heart Assoc 5:
MeSH Terms: Action Potentials, Animals, Electrocardiography, Heart, Heart Ventricles, Isolated Heart Preparation, Mice, Mice, Knockout, Myocardium, Myocytes, Cardiac, NAV1.8 Voltage-Gated Sodium Channel, Patch-Clamp Techniques, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction
Added February 3, 2017
1 Communities
2 Members
0 Resources
14 MeSH Terms
Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.
Behr ER, Savio-Galimberti E, Barc J, Holst AG, Petropoulou E, Prins BP, Jabbari J, Torchio M, Berthet M, Mizusawa Y, Yang T, Nannenberg EA, Dagradi F, Weeke P, Bastiaenan R, Ackerman MJ, Haunso S, Leenhardt A, Kääb S, Probst V, Redon R, Sharma S, Wilde A, Tfelt-Hansen J, Schwartz P, Roden DM, Bezzina CR, Olesen M, Darbar D, Guicheney P, Crotti L, UK10K Consortium, Jamshidi Y
(2015) Cardiovasc Res 106: 520-9
MeSH Terms: Action Potentials, Adult, Aged, Brugada Syndrome, Case-Control Studies, Cell Line, Computational Biology, DNA Mutational Analysis, Databases, Genetic, Europe, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Heredity, Humans, Male, Middle Aged, NAV1.8 Voltage-Gated Sodium Channel, Odds Ratio, Pedigree, Phenotype, Polymorphism, Single Nucleotide, Risk Factors, Saudi Arabia, Transfection, United States
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation.
Savio-Galimberti E, Weeke P, Muhammad R, Blair M, Ansari S, Short L, Atack TC, Kor K, Vanoye CG, Olesen MS, LuCamp , Yang T, George AL, Roden DM, Darbar D
(2014) Cardiovasc Res 104: 355-63
MeSH Terms: Adolescent, Adult, Age of Onset, Aged, Atrial Fibrillation, Cell Line, DNA Mutational Analysis, Female, Gene Frequency, Genetic Predisposition to Disease, Heart Rate, Heterozygote, Humans, Male, Membrane Potentials, Middle Aged, Mutation, Myocytes, Cardiac, NAV1.8 Voltage-Gated Sodium Channel, Phenotype, Registries, Sodium, Tennessee, Time Factors, Transfection, Young Adult
Added January 20, 2015
0 Communities
2 Members
0 Resources
26 MeSH Terms
Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation.
Delaney JT, Muhammad R, Shi Y, Schildcrout JS, Blair M, Short L, Roden DM, Darbar D
(2014) Europace 16: 485-90
MeSH Terms: Action Potentials, Aged, Atrial Fibrillation, Electrocardiography, Female, Genetic Predisposition to Disease, Heart Conduction System, Heart Rate, Humans, Male, Middle Aged, NAV1.8 Voltage-Gated Sodium Channel, Phenotype, Polymorphism, Single Nucleotide, Prospective Studies, Registries, Risk Assessment, Risk Factors, Tennessee, Time Factors
Added March 7, 2014
0 Communities
3 Members
0 Resources
20 MeSH Terms
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Borggrefe M, Schimpf R, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bézieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott JJ, Dina C, Redon R
(2013) Nat Genet 45: 1044-9
MeSH Terms: Alleles, Animals, Basic Helix-Loop-Helix Transcription Factors, Brugada Syndrome, Case-Control Studies, Chromosomes, Human, Pair 3, Chromosomes, Human, Pair 6, Death, Sudden, Cardiac, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Male, Mice, Mice, Knockout, NAV1.5 Voltage-Gated Sodium Channel, NAV1.8 Voltage-Gated Sodium Channel, Odds Ratio, Polymorphism, Single Nucleotide, Repressor Proteins, Sodium Channels
Added March 7, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic.
Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM
(2012) Circ Res 111: 322-32
MeSH Terms: Action Potentials, Aniline Compounds, Animals, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Cell Line, Transformed, Furans, Humans, Mice, Mice, Knockout, NAV1.5 Voltage-Gated Sodium Channel, NAV1.8 Voltage-Gated Sodium Channel, Rabbits, Rats, Sodium Channel Blockers, Sodium Channels
Added June 26, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science.
Denny JC, Ritchie MD, Crawford DC, Schildcrout JS, Ramirez AH, Pulley JM, Basford MA, Masys DR, Haines JL, Roden DM
(2010) Circulation 122: 2016-21
MeSH Terms: Adult, Aged, Databases, Nucleic Acid, Electrocardiography, Electronic Health Records, Female, Genome-Wide Association Study, Genotype, Heart, Humans, Male, Middle Aged, NAV1.8 Voltage-Gated Sodium Channel, Polymorphism, Single Nucleotide, Sodium Channels
Added March 7, 2014
0 Communities
5 Members
0 Resources
15 MeSH Terms