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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 39

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Deep Mutational Scan of an Voltage Sensor.
Glazer AM, Kroncke BM, Matreyek KA, Yang T, Wada Y, Shields T, Salem JE, Fowler DM, Roden DM
(2020) Circ Genom Precis Med 13: e002786
MeSH Terms: Cardiotonic Agents, DNA Mutational Analysis, HEK293 Cells, Humans, Marine Toxins, Mutation, NAV1.5 Voltage-Gated Sodium Channel, Ouabain, Oxocins, Pharmacogenomic Testing, Veratridine
Added March 4, 2020
0 Communities
2 Members
0 Resources
11 MeSH Terms
SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells.
Daniel LL, Yang T, Kroncke B, Hall L, Stroud D, Roden DM
(2019) Heart Rhythm 16: 1676-1685
MeSH Terms: Action Potentials, Alleles, Animals, Disease Models, Animal, Echocardiography, Electrocardiography, Mice, Mice, Transgenic, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Purkinje Cells, Sodium Channels
Added June 14, 2019
1 Communities
2 Members
0 Resources
12 MeSH Terms
Electrophysiologic and molecular mechanisms of a frameshift NPPA mutation linked with familial atrial fibrillation.
Menon A, Hong L, Savio-Galimberti E, Sridhar A, Youn SW, Zhang M, Kor K, Blair M, Kupershmidt S, Darbar D
(2019) J Mol Cell Cardiol 132: 24-35
MeSH Terms: Action Potentials, Animals, Atrial Fibrillation, Atrial Natriuretic Factor, Electrophysiological Phenomena, Frameshift Mutation, Heart Atria, Humans, Membrane Potentials, Mice, Mice, Transgenic, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel
Added June 14, 2019
1 Communities
0 Members
0 Resources
13 MeSH Terms
Multiple mechanisms underlie increased cardiac late sodium current.
Kroncke BM, Yang T, Roden DM
(2019) Heart Rhythm 16: 1091-1097
MeSH Terms: Action Potentials, Animals, CHO Cells, Cardiac Conduction System Disease, Cricetinae, Cricetulus, Genotype, Humans, Induced Pluripotent Stem Cells, Kidney, Long QT Syndrome, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Phenotype, Phosphatidylinositol 3-Kinases
Added March 26, 2019
0 Communities
3 Members
0 Resources
15 MeSH Terms
(Na1.5) Variant Functional Perturbation and Clinical Presentation: Variants of a Certain Significance.
Kroncke BM, Glazer AM, Smith DK, Blume JD, Roden DM
(2018) Circ Genom Precis Med 11: e002095
MeSH Terms: Animals, Cell Line, Humans, Models, Genetic, Mutation, NAV1.5 Voltage-Gated Sodium Channel, Penetrance, Probability, Statistics, Nonparametric, Uncertainty
Added March 26, 2019
0 Communities
3 Members
0 Resources
10 MeSH Terms
A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.
Johnson CN, Potet F, Thompson MK, Kroncke BM, Glazer AM, Voehler MW, Knollmann BC, George AL, Chazin WJ
(2018) Structure 26: 683-694.e3
MeSH Terms: Binding Sites, Calcium, Calmodulin, Crystallography, X-Ray, Gene Expression Regulation, Humans, Kinetics, Models, Molecular, Mutation, NAV1.5 Voltage-Gated Sodium Channel, Protein Binding
Added March 26, 2019
0 Communities
3 Members
0 Resources
MeSH Terms
Classification and Reporting of Potentially Proarrhythmic Common Genetic Variation in Long QT Syndrome Genetic Testing.
Giudicessi JR, Roden DM, Wilde AAM, Ackerman MJ
(2018) Circulation 137: 619-630
MeSH Terms: Action Potentials, Diagnostic Errors, Genetic Predisposition to Disease, Genetic Testing, Genetic Variation, Heart Conduction System, Heart Rate, Humans, Long QT Syndrome, NAV1.5 Voltage-Gated Sodium Channel, Phenotype, Potassium Channels, Voltage-Gated, Predictive Value of Tests, Prognosis, Reproducibility of Results, Risk Assessment, Risk Factors
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Azithromycin Causes a Novel Proarrhythmic Syndrome.
Yang Z, Prinsen JK, Bersell KR, Shen W, Yermalitskaya L, Sidorova T, Luis PB, Hall L, Zhang W, Du L, Milne G, Tucker P, George AL, Campbell CM, Pickett RA, Shaffer CM, Chopra N, Yang T, Knollmann BC, Roden DM, Murray KT
(2017) Circ Arrhythm Electrophysiol 10:
MeSH Terms: Action Potentials, Animals, Anti-Bacterial Agents, Arrhythmias, Cardiac, Azithromycin, CHO Cells, Calcium Channel Blockers, Calcium Channels, L-Type, Cricetulus, Dose-Response Relationship, Drug, Electrocardiography, Ambulatory, Female, HEK293 Cells, Heart Rate, Humans, KCNQ1 Potassium Channel, Mice, Inbred C57BL, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Potassium Channel Blockers, Potassium Channels, Inwardly Rectifying, Potassium Channels, Voltage-Gated, Rabbits, Sodium Channel Blockers, Telemetry, Time Factors, Transfection, Young Adult
Added July 6, 2017
0 Communities
2 Members
0 Resources
28 MeSH Terms
Transcription factor ETV1 is essential for rapid conduction in the heart.
Shekhar A, Lin X, Liu FY, Zhang J, Mo H, Bastarache L, Denny JC, Cox NJ, Delmar M, Roden DM, Fishman GI, Park DS
(2016) J Clin Invest 126: 4444-4459
MeSH Terms: Animals, DNA-Binding Proteins, Heart Atria, Heart Conduction System, Heart Ventricles, Homeobox Protein Nkx-2.5, Humans, Mice, Mice, Transgenic, Myocardium, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Transcription Factors
Added March 14, 2018
0 Communities
2 Members
0 Resources
13 MeSH Terms
Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes.
Yagihara N, Watanabe H, Barnett P, Duboscq-Bidot L, Thomas AC, Yang P, Ohno S, Hasegawa K, Kuwano R, Chatel S, Redon R, Schott JJ, Probst V, Koopmann TT, Bezzina CR, Wilde AA, Nakano Y, Aiba T, Miyamoto Y, Kamakura S, Darbar D, Donahue BS, Shigemizu D, Tanaka T, Tsunoda T, Suda M, Sato A, Minamino T, Endo N, Shimizu W, Horie M, Roden DM, Makita N
(2016) J Am Heart Assoc 5:
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Arrhythmias, Cardiac, Atrial Fibrillation, Brugada Syndrome, Cardiac Conduction System Disease, Child, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Male, Middle Aged, Mutation, NAV1.5 Voltage-Gated Sodium Channel, Phenotype, Promoter Regions, Genetic, Sick Sinus Syndrome, Ventricular Fibrillation, Young Adult
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms