Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 1 to 9 of 9

Publication Record

Connections

The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model.
Hawkins NA, Lewis M, Hammond RS, Doherty JJ, Kearney JA
(2017) Sci Rep 7: 15327
MeSH Terms: Animals, Anticonvulsants, Epilepsies, Myoclonic, GABA-A Receptor Agonists, Hydroxycholesterols, Mice, Mice, Mutant Strains, NAV1.1 Voltage-Gated Sodium Channel, Receptors, GABA-A
Added October 2, 2018
1 Communities
0 Members
0 Resources
9 MeSH Terms
Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome.
Anderson LL, Hawkins NA, Thompson CH, Kearney JA, George AL
(2017) Sci Rep 7: 1682
MeSH Terms: Action Potentials, Animals, Epilepsies, Myoclonic, Ion Channel Gating, Mice, Inbred C57BL, Mice, Knockout, NAV1.1 Voltage-Gated Sodium Channel, NAV1.6 Voltage-Gated Sodium Channel, Neurons, Pyramidal Cells, Pyridines, Seizures, Survival Analysis, Triazoles
Added October 2, 2018
1 Communities
0 Members
0 Resources
14 MeSH Terms
Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq.
Hawkins NA, Zachwieja NJ, Miller AR, Anderson LL, Kearney JA
(2016) PLoS Genet 12: e1006398
MeSH Terms: Animals, Benzodiazepines, Chromosome Mapping, Chromosomes, Clobazam, Disease Models, Animal, Epilepsies, Myoclonic, Epilepsy, Gene Expression Regulation, Genes, Modifier, Genetic Association Studies, High-Throughput Nucleotide Sequencing, Humans, Mice, Mice, Knockout, Mutation, NAV1.1 Voltage-Gated Sodium Channel, Phenotype, Receptors, GABA-A, Seizures
Added October 2, 2018
1 Communities
0 Members
0 Resources
20 MeSH Terms
Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice.
Mistry AM, Thompson CH, Miller AR, Vanoye CG, George AL, Kearney JA
(2014) Neurobiol Dis 65: 1-11
MeSH Terms: Age Factors, Animals, Animals, Newborn, Cells, Cultured, Disease Models, Animal, Electric Stimulation, Epilepsies, Myoclonic, Female, Glial Fibrillary Acidic Protein, Glutamate Decarboxylase, Heterozygote, Hippocampus, In Vitro Techniques, Male, Membrane Potentials, Mice, Mice, Transgenic, NAV1.1 Voltage-Gated Sodium Channel, Nerve Tissue Proteins, Neurons
Added May 27, 2014
1 Communities
1 Members
0 Resources
20 MeSH Terms
Ranolazine reduces neuronal excitability by interacting with inactivated states of brain sodium channels.
Kahlig KM, Hirakawa R, Liu L, George AL, Belardinelli L, Rajamani S
(2014) Mol Pharmacol 85: 162-74
MeSH Terms: Acetanilides, Action Potentials, Animals, Anticonvulsants, Cells, Cultured, Computer Simulation, Epilepsy, Hippocampus, Humans, Markov Chains, N-Methylaspartate, NAV1.1 Voltage-Gated Sodium Channel, NAV1.2 Voltage-Gated Sodium Channel, Neurons, Patch-Clamp Techniques, Piperazines, Protein Binding, Protein Conformation, Ranolazine, Rats, Voltage-Gated Sodium Channels
Added March 7, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Mapping genetic modifiers of survival in a mouse model of Dravet syndrome.
Miller AR, Hawkins NA, McCollom CE, Kearney JA
(2014) Genes Brain Behav 13: 163-72
MeSH Terms: Animals, Chromosomes, Epilepsies, Myoclonic, Genes, Modifier, Mice, Mice, Inbred C57BL, NAV1.1 Voltage-Gated Sodium Channel, Penetrance, Quantitative Trait Loci
Added May 27, 2014
1 Communities
1 Members
0 Resources
9 MeSH Terms
Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.
Hawkins NA, Martin MS, Frankel WN, Kearney JA, Escayg A
(2011) Neurobiol Dis 41: 655-60
MeSH Terms: Alleles, Animals, Epilepsy, Generalized, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, KCNQ2 Potassium Channel, Male, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Transgenic, Mutation, NAV1.1 Voltage-Gated Sodium Channel, NAV1.2 Voltage-Gated Sodium Channel, NAV1.6 Voltage-Gated Sodium Channel, Nerve Tissue Proteins, Neurons, Phenotype, Seizures, Febrile, Sodium Channels
Added May 27, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Multiplexed transposon-mediated stable gene transfer in human cells.
Kahlig KM, Saridey SK, Kaja A, Daniels MA, George AL, Wilson MH
(2010) Proc Natl Acad Sci U S A 107: 1343-8
MeSH Terms: Cell Line, DNA Transposable Elements, Gene Expression, Genetic Markers, Humans, NAV1.1 Voltage-Gated Sodium Channel, Nerve Tissue Proteins, Open Reading Frames, Protein Binding, Sodium Channels, Transgenes
Added March 14, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Early treatment suppresses the development of spike-wave epilepsy in a rat model.
Blumenfeld H, Klein JP, Schridde U, Vestal M, Rice T, Khera DS, Bashyal C, Giblin K, Paul-Laughinghouse C, Wang F, Phadke A, Mission J, Agarwal RK, Englot DJ, Motelow J, Nersesyan H, Waxman SG, Levin AR
(2008) Epilepsia 49: 400-9
MeSH Terms: Animals, Animals, Newborn, Anticonvulsants, Cerebral Cortex, Cyclic Nucleotide-Gated Cation Channels, Disease Models, Animal, Electroencephalography, Epilepsy, Absence, Ethosuximide, Female, Humans, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Ion Channels, NAV1.1 Voltage-Gated Sodium Channel, NAV1.6 Voltage-Gated Sodium Channel, Nerve Tissue Proteins, Phenotype, Potassium Channels, Rats, Rats, Wistar, Severity of Illness Index, Sodium Channels
Added August 12, 2016
0 Communities
1 Members
0 Resources
22 MeSH Terms