Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 1 to 10 of 63

Publication Record

Connections

Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.
Gonzalez E, Guengerich FP
(2017) J Biol Chem 292: 13168-13185
MeSH Terms: 17-alpha-Hydroxypregnenolone, Androstenedione, Animals, Binding Sites, Biocatalysis, Cytochrome P-450 Enzyme Inhibitors, Cytochromes b5, Dehydroepiandrosterone, Humans, Imidazoles, Kinetics, Ligands, Models, Molecular, NADPH-Ferrihemoprotein Reductase, Naphthalenes, Oxidation-Reduction, Pregnenolone, Progesterone, Protein Conformation, Rats, Recombinant Proteins, Stereoisomerism, Steroid 17-alpha-Hydroxylase
Added March 14, 2018
0 Communities
1 Members
0 Resources
23 MeSH Terms
Cytochrome P450 2S1 is reduced by NADPH-cytochrome P450 reductase.
Xiao Y, Shinkyo R, Guengerich FP
(2011) Drug Metab Dispos 39: 944-6
MeSH Terms: Aerobiosis, Anaerobiosis, Animals, Anthraquinones, Cytochrome P-450 Enzyme System, Electron Transport, Escherichia coli, Humans, NADPH-Ferrihemoprotein Reductase, Oxidation-Reduction, Oxygen, Rats
Added March 7, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Clinical, genetic, and enzymatic characterization of P450 oxidoreductase deficiency in four patients.
Sahakitrungruang T, Huang N, Tee MK, Agrawal V, Russell WE, Crock P, Murphy N, Migeon CJ, Miller WL
(2009) J Clin Endocrinol Metab 94: 4992-5000
MeSH Terms: Adolescent, Adult, Bone and Bones, Catalysis, Cytochromes c, DNA, Disorders of Sex Development, Escherichia coli, Female, Genetic Vectors, Genitalia, Hormones, Humans, Infant, Newborn, Infertility, Male, Mutation, NADP, NADPH-Ferrihemoprotein Reductase, Pregnancy, Steroid 17-alpha-Hydroxylase, Syndrome
Added May 5, 2016
0 Communities
1 Members
0 Resources
22 MeSH Terms
Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase.
Guengerich FP, Martin MV, Sohl CD, Cheng Q
(2009) Nat Protoc 4: 1245-51
MeSH Terms: Animals, Cytochrome P-450 Enzyme System, Humans, Microsomes, Liver, NADPH-Ferrihemoprotein Reductase, Rats, Spectrophotometry
Added March 26, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
A second FMN binding site in yeast NADPH-cytochrome P450 reductase suggests a mechanism of electron transfer by diflavin reductases.
Lamb DC, Kim Y, Yermalitskaya LV, Yermalitsky VN, Lepesheva GI, Kelly SL, Waterman MR, Podust LM
(2006) Structure 14: 51-61
MeSH Terms: Amino Acid Sequence, Animals, Binding Sites, Crystallography, X-Ray, Electron Transport, Flavin Mononucleotide, Flavin-Adenine Dinucleotide, Humans, Molecular Sequence Data, NADPH-Ferrihemoprotein Reductase, Rabbits, Rats, Saccharomyces cerevisiae Proteins, Sequence Alignment
Added February 12, 2015
0 Communities
2 Members
0 Resources
14 MeSH Terms
Reduction of cytochrome b5 by NADPH-cytochrome P450 reductase.
Guengerich FP
(2005) Arch Biochem Biophys 440: 204-11
MeSH Terms: Animals, Cytochromes b5, Cytochromes c, Detergents, Electron Transport, Kinetics, Lipids, Microsomes, Liver, NADPH-Ferrihemoprotein Reductase, Osmolar Concentration, Oxidation-Reduction, Phosphatidylcholines, Protein Binding, Rats, Transport Vesicles
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes.
Shimada T, Mernaugh RL, Guengerich FP
(2005) Arch Biochem Biophys 435: 207-16
MeSH Terms: Coenzymes, Cytochrome P-450 Enzyme System, Cytochromes b5, Enzyme Activation, Enzymes, Immobilized, Ferredoxins, Humans, Kinetics, NADH, NADPH Oxidoreductases, NADPH-Ferrihemoprotein Reductase, Protein Binding, Protein Interaction Mapping, Pseudomonas putida, Substrate Specificity
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Non-specific inhibition of human cytochrome P450-catalyzed reactions by hemin.
Kim EY, Kim JS, Kim MY, Koh WS, Guengerich FP, Yun CH
(2004) Toxicol Lett 153: 239-46
MeSH Terms: Catalysis, Cytochrome P-450 Enzyme Inhibitors, Enzyme Inhibitors, Hemin, Humans, Microsomes, Liver, NADPH-Ferrihemoprotein Reductase
Added May 26, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines.
Kim D, Kadlubar FF, Teitel CH, Guengerich FP
(2004) Chem Res Toxicol 17: 529-36
MeSH Terms: Carcinogens, Catalysis, Chromatography, High Pressure Liquid, Escherichia coli, Kinetics, Mass Spectrometry, Models, Theoretical, Mutagenicity Tests, NADP, NADPH-Ferrihemoprotein Reductase, Nitroso Compounds, Oxidation-Reduction, Quinolines, Salmonella typhimurium
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.
Henderson CJ, Otto DM, Carrie D, Magnuson MA, McLaren AW, Rosewell I, Wolf CR
(2003) J Biol Chem 278: 13480-6
MeSH Terms: Acetaminophen, Animals, Cytochrome P-450 Enzyme System, Exons, Female, Gene Deletion, Genomic Library, Glutathione, Liver, Male, Mice, Mice, Knockout, Mice, Transgenic, NADPH-Ferrihemoprotein Reductase, Pentobarbital, Promoter Regions, Genetic, Rats, Restriction Mapping, Serum Albumin, Sex Characteristics
Added February 23, 2011
1 Communities
1 Members
0 Resources
20 MeSH Terms