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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 5 of 5

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Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm.
Chmielecki J, Peifer M, Viale A, Hutchinson K, Giltnane J, Socci ND, Hollis CJ, Dean RS, Yenamandra A, Jagasia M, Kim AS, Davé UP, Thomas RK, Pao W
(2012) Genes Chromosomes Cancer 51: 54-65
MeSH Terms: Adult, Algorithms, Amino Acid Sequence, Base Sequence, Cell Line, Tumor, Computational Biology, Cytoskeletal Proteins, Gene Order, HEK293 Cells, Humans, K562 Cells, Karyotyping, Male, Molecular Sequence Data, Myeloproliferative Disorders, Oncogene Proteins, Fusion, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Protein-Tyrosine Kinases, Sequence Alignment, Sequence Analysis, DNA, Translocation, Genetic
Added September 3, 2013
0 Communities
4 Members
0 Resources
21 MeSH Terms
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.
Kotecha N, Flores NJ, Irish JM, Simonds EF, Sakai DS, Archambeault S, Diaz-Flores E, Coram M, Shannon KM, Nolan GP, Loh ML
(2008) Cancer Cell 14: 335-43
MeSH Terms: Adult, Biomarkers, Tumor, Cell Proliferation, Cells, Cultured, Child, Disease Progression, Flow Cytometry, Gene Expression Regulation, Neoplastic, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Janus Kinase 2, Leukemia, Myelomonocytic, Juvenile, Myeloproliferative Disorders, Neoplasm Staging, Phosphorylation, Recurrence, STAT5 Transcription Factor, Signal Transduction, Treatment Outcome
Added February 15, 2013
1 Communities
1 Members
0 Resources
19 MeSH Terms
K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells.
Van Meter ME, Díaz-Flores E, Archard JA, Passegué E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun BS
(2007) Blood 109: 3945-52
MeSH Terms: Animals, Cell Proliferation, Extracellular Signal-Regulated MAP Kinases, Granulocyte-Macrophage Colony-Stimulating Factor, Hematopoietic Stem Cells, Mice, Mice, Transgenic, Myeloproliferative Disorders, Neoplastic Stem Cells, Point Mutation, Proto-Oncogene Proteins p21(ras), Ribosomal Protein S6 Kinases, STAT5 Transcription Factor, Signal Transduction
Added February 15, 2013
1 Communities
1 Members
0 Resources
14 MeSH Terms
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.
Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, Korsmeyer SJ
(2005) EMBO J 24: 368-81
MeSH Terms: Animals, CREB-Binding Protein, DNA-Binding Proteins, Histone-Lysine N-Methyltransferase, Mice, Molecular Sequence Data, Myeloid-Lymphoid Leukemia Protein, Myeloproliferative Disorders, Nuclear Proteins, Proto-Oncogenes, Reverse Transcriptase Polymerase Chain Reaction, Trans-Activators, Transcription Factors
Added April 7, 2010
0 Communities
1 Members
0 Resources
13 MeSH Terms
Proapoptotic BID is required for myeloid homeostasis and tumor suppression.
Zinkel SS, Ong CC, Ferguson DO, Iwasaki H, Akashi K, Bronson RT, Kutok JL, Alt FW, Korsmeyer SJ
(2003) Genes Dev 17: 229-39
MeSH Terms: Animals, Apoptosis, BH3 Interacting Domain Death Agonist Protein, Carrier Proteins, Chromosome Aberrations, Female, Homeostasis, Leukemia, Myelomonocytic, Chronic, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Myelopoiesis, Myeloproliferative Disorders, Signal Transduction
Added September 7, 2011
1 Communities
1 Members
0 Resources
15 MeSH Terms