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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 137

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Sox6 as a new modulator of renin expression in the kidney.
Saleem M, Hodgkinson CP, Xiao L, Gimenez-Bastida JA, Rasmussen ML, Foss J, Payne AJ, Mirotsou M, Gama V, Dzau VJ, Gomez JA
(2020) Am J Physiol Renal Physiol 318: F285-F297
MeSH Terms: Animals, Arterioles, Blood Pressure, Cell Differentiation, Cell Proliferation, Cells, Cultured, Diet, Sodium-Restricted, Diuretics, Furosemide, Gene Expression Regulation, Juxtaglomerular Apparatus, Male, Mesenchymal Stem Cells, Mice, Inbred C57BL, Mice, Knockout, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Renin, SOXD Transcription Factors, Signal Transduction
Added August 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Comparative analysis of myometrial and vascular smooth muscle cells to determine optimal cells for use in drug discovery.
Siricilla S, Knapp KM, Rogers JH, Berger C, Shelton EL, Mi D, Vinson P, Condon J, Paria BC, Reese J, Sheng Q, Herington JL
(2019) Pharmacol Res 146: 104268
MeSH Terms: Adolescent, Adult, Animals, Cells, Cultured, Drug Discovery, Female, High-Throughput Screening Assays, Humans, Mice, Middle Aged, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Myometrium, Pregnancy, Transcriptome, Young Adult
Added July 28, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Apoptosis signal-regulating kinase 1 activation by Nox1-derived oxidants is required for TNFα receptor endocytosis.
Choi H, Stark RJ, Raja BS, Dikalova A, Lamb FS
(2019) Am J Physiol Heart Circ Physiol 316: H1528-H1537
MeSH Terms: Animals, Aorta, Thoracic, Cells, Cultured, Endocytosis, MAP Kinase Kinase Kinase 5, Mice, Inbred C57BL, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, NADPH Oxidase 1, Receptors, Tumor Necrosis Factor, Type I, Signal Transduction, Superoxides, Tumor Necrosis Factor-alpha
Added April 3, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Loss of SPRR3 in ApoE-/- mice leads to atheroma vulnerability through Akt dependent and independent effects in VSMCs.
Lietman CD, Segedy AK, Li B, Fazio S, Atkinson JB, Linton MF, Young PP
(2017) PLoS One 12: e0184620
MeSH Terms: Animals, Apolipoproteins E, Cornified Envelope Proline-Rich Proteins, Female, Fibronectins, Immunoblotting, Mice, Mice, Inbred C57BL, Mice, Knockout, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Real-Time Polymerase Chain Reaction, Signal Transduction
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Endoglin Mediates Vascular Maturation by Promoting Vascular Smooth Muscle Cell Migration and Spreading.
Tian H, Ketova T, Hardy D, Xu X, Gao X, Zijlstra A, Blobe GC
(2017) Arterioscler Thromb Vasc Biol 37: 1115-1126
MeSH Terms: Animals, CRISPR-Cas Systems, Cell Movement, Cell Shape, Cells, Cultured, Coculture Techniques, Endoglin, Endothelial Cells, Focal Adhesion Kinase 1, Gene Expression Regulation, Humans, Integrins, Mice, Inbred C57BL, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Phenotype, RNA Interference, Signal Transduction, Transfection
Added March 22, 2018
0 Communities
1 Members
0 Resources
19 MeSH Terms
Use of Brilliant Blue FCF during vein graft preparation inhibits intimal hyperplasia.
Osgood MJ, Sexton K, Voskresensky I, Hocking K, Song J, Komalavilas P, Brophy C, Cheung-Flynn J
(2016) J Vasc Surg 64: 471-478
MeSH Terms: Animals, Benzenesulfonates, Cell Line, Cell Movement, Cell Proliferation, Coloring Agents, Humans, Hyperplasia, Jugular Veins, Models, Animal, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Neointima, Organ Culture Techniques, Purinergic P2X Receptor Antagonists, Rabbits, Rats, Receptors, Purinergic P2X7, Saphenous Vein, Signal Transduction, Time Factors, Tissue and Organ Harvesting
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Papaverine Prevents Vasospasm by Regulation of Myosin Light Chain Phosphorylation and Actin Polymerization in Human Saphenous Vein.
Hocking KM, Putumbaka G, Wise ES, Cheung-Flynn J, Brophy CM, Komalavilas P
(2016) PLoS One 11: e0154460
MeSH Terms: Actins, Calcium, Humans, Immunoblotting, Muscle, Smooth, Vascular, Myosin Light Chains, Papaverine, Phosphorylation, Saphenous Vein, Tissue Culture Techniques
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension.
Wu J, Montaniel KR, Saleh MA, Xiao L, Chen W, Owens GK, Humphrey JD, Majesky MW, Paik DT, Hatzopoulos AK, Madhur MS, Harrison DG
(2016) Hypertension 67: 461-8
MeSH Terms: Animals, Aorta, Thoracic, Aortic Diseases, Cells, Cultured, Collagen, Disease Models, Animal, Extracellular Matrix Proteins, Fibroblasts, Fibrosis, Flow Cytometry, Hypertension, Immunohistochemistry, Male, Mice, Mice, Inbred C57BL, Muscle, Smooth, Vascular
Show Abstract · Added February 23, 2016
Various hypertensive stimuli lead to exuberant adventitial collagen deposition in large arteries, exacerbating blood pressure elevation and end-organ damage. Collagen production is generally attributed to resident fibroblasts; however, other cells, including resident and bone marrow-derived stem cell antigen positive (Sca-1(+)) cells and endothelial and vascular smooth muscle cells, can produce collagen and contribute to vascular stiffening. Using flow cytometry and immunofluorescence, we found that adventitial Sca-1(+) progenitor cells begin to produce collagen and acquire a fibroblast-like phenotype in hypertension. We also found that bone marrow-derived cells represent more than half of the matrix-producing cells in hypertension, and that one-third of these are Sca-1(+). Cell sorting and lineage-tracing studies showed that cells of endothelial origin contribute to no more than one fourth of adventitial collagen I(+) cells, whereas those of vascular smooth muscle lineage do not contribute. Our findings indicate that Sca-1(+) progenitor cells and bone marrow-derived infiltrating fibrocytes are major sources of arterial fibrosis in hypertension. Endothelial to mesenchymal transition likely also contributes, albeit to a lesser extent and pre-existing resident fibroblasts represent a minority of aortic collagen-producing cells in hypertension. This study shows that vascular stiffening represents a complex process involving recruitment and transformation of multiple cells types that ultimately elaborate adventitial extracellular matrix.
© 2015 American Heart Association, Inc.
2 Communities
2 Members
0 Resources
16 MeSH Terms
Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension.
Bryant AJ, Carrick RP, McConaha ME, Jones BR, Shay SD, Moore CS, Blackwell TR, Gladson S, Penner NL, Burman A, Tanjore H, Hemnes AR, Karwandyar AK, Polosukhin VV, Talati MA, Dong HJ, Gleaves LA, Carrier EJ, Gaskill C, Scott EW, Majka SM, Fessel JP, Haase VH, West JD, Blackwell TS, Lawson WE
(2016) Am J Physiol Lung Cell Mol Physiol 310: L249-62
MeSH Terms: Animals, Cell Proliferation, Cells, Cultured, Endothelial Cells, Endothelium, Vascular, Fibrosis, Hypertension, Pulmonary, Hypoxia, Hypoxia-Inducible Factor 1, Mice, Transgenic, Muscle, Smooth, Vascular, Pulmonary Artery, Vascular Remodeling
Added February 16, 2016
1 Communities
5 Members
0 Resources
13 MeSH Terms
Aldosterone in vascular and metabolic dysfunction.
Luther JM
(2016) Curr Opin Nephrol Hypertens 25: 16-21
MeSH Terms: Adipocytes, Aldosterone, Animals, Blood Glucose, Blood Pressure, Coronary Circulation, Diabetic Nephropathies, Humans, Mineralocorticoid Receptor Antagonists, Muscle, Smooth, Vascular, Receptors, Mineralocorticoid, Vascular Endothelial Growth Factor Receptor-1
Added November 30, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms