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Response of Secondary Metabolism of Hypogean Actinobacterial Genera to Chemical and Biological Stimuli.
Covington BC, Spraggins JM, Ynigez-Gutierrez AE, Hylton ZB, Bachmann BO
(2018) Appl Environ Microbiol 84:
MeSH Terms: Actinobacteria, Bacterial Proteins, Biological Products, Caves, Genome, Bacterial, Magnetic Resonance Spectroscopy, Metabolomics, Multigene Family, Phylogeny, Polyketides, Secondary Metabolism
Added March 26, 2019
0 Communities
1 Members
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11 MeSH Terms
Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species.
Lind AL, Wisecaver JH, Lameiras C, Wiemann P, Palmer JM, Keller NP, Rodrigues F, Goldman GH, Rokas A
(2017) PLoS Biol 15: e2003583
MeSH Terms: Alleles, Aspergillus fumigatus, Biological Evolution, Fungal Proteins, Fungi, Genetic Variation, Genome, Fungal, Genomics, Metabolic Networks and Pathways, Multigene Family, Mutation, Polymorphism, Genetic, Secondary Metabolism
Added March 21, 2018
0 Communities
1 Members
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13 MeSH Terms
A Global Coexpression Network Approach for Connecting Genes to Specialized Metabolic Pathways in Plants.
Wisecaver JH, Borowsky AT, Tzin V, Jander G, Kliebenstein DJ, Rokas A
(2017) Plant Cell 29: 944-959
MeSH Terms: Computational Biology, Gene Expression Profiling, Gene Expression Regulation, Plant, Metabolic Networks and Pathways, Multigene Family
Added March 21, 2018
0 Communities
1 Members
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5 MeSH Terms
CTDGFinder: A Novel Homology-Based Algorithm for Identifying Closely Spaced Clusters of Tandemly Duplicated Genes.
Ortiz JF, Rokas A
(2017) Mol Biol Evol 34: 215-229
MeSH Terms: Algorithms, Animals, Evolution, Molecular, Genes, Duplicate, Genetic Linkage, Genome, Genomics, Humans, Multigene Family, Phylogeny, Sequence Analysis, DNA, Sequence Homology, Nucleic Acid, Software, Synteny, Tandem Repeat Sequences
Added April 6, 2017
0 Communities
1 Members
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15 MeSH Terms
Regulation of Secondary Metabolism by the Velvet Complex Is Temperature-Responsive in Aspergillus.
Lind AL, Smith TD, Saterlee T, Calvo AM, Rokas A
(2016) G3 (Bethesda) 6: 4023-4033
MeSH Terms: Aspergillus, Cluster Analysis, Fungal Proteins, Gene Expression Profiling, Gene Expression Regulation, Fungal, Multigene Family, Secondary Metabolism, Temperature
Added April 6, 2017
0 Communities
1 Members
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8 MeSH Terms
High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML.
Zhao Y, Liu Q, Acharya P, Stengel KR, Sheng Q, Zhou X, Kwak H, Fischer MA, Bradner JE, Strickland SA, Mohan SR, Savona MR, Venters BJ, Zhou MM, Lis JT, Hiebert SW
(2016) Cell Rep 16: 2003-16
MeSH Terms: Antineoplastic Agents, Azepines, Cell Line, Tumor, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 8, Clustered Regularly Interspaced Short Palindromic Repeats, DNA-Directed RNA Polymerases, Drug Resistance, Neoplasm, Enhancer Elements, Genetic, Gene Expression Regulation, Leukemic, High-Throughput Nucleotide Sequencing, Humans, Leukemia, Myeloid, Acute, MicroRNAs, Multigene Family, Myeloid Cell Leukemia Sequence 1 Protein, Promoter Regions, Genetic, Protein Isoforms, Proteins, Proto-Oncogene Proteins c-kit, Transcription, Genetic, Translocation, Genetic, Triazoles
Added April 6, 2017
0 Communities
1 Members
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23 MeSH Terms
Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function.
Henley KD, Stanescu DE, Kropp PA, Wright CVE, Won KJ, Stoffers DA, Gannon M
(2016) Cell Rep 15: 2637-2650
MeSH Terms: Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Count, Cell Differentiation, Embryo, Mammalian, Gene Dosage, Gene Expression Regulation, Developmental, Gene Ontology, Gene Regulatory Networks, Glucose, Hepatocyte Nuclear Factor 6, Heterozygote, Homeodomain Proteins, Homeostasis, Insulin-Secreting Cells, Mice, Multigene Family, Nerve Tissue Proteins, Stem Cells, Trans-Activators, Weaning
Added July 5, 2016
1 Communities
2 Members
0 Resources
21 MeSH Terms
Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects.
Machado RD, Southgate L, Eichstaedt CA, Aldred MA, Austin ED, Best DH, Chung WK, Benjamin N, Elliott CG, Eyries M, Fischer C, Gräf S, Hinderhofer K, Humbert M, Keiles SB, Loyd JE, Morrell NW, Newman JH, Soubrier F, Trembath RC, Viales RR, Grünig E
(2015) Hum Mutat 36: 1113-27
MeSH Terms: Animals, Bone Morphogenetic Protein Receptors, Type II, Disease Models, Animal, Genetic Association Studies, Genetic Counseling, Genetic Predisposition to Disease, Genetic Variation, High-Throughput Nucleotide Sequencing, Humans, Hypertension, Pulmonary, Multigene Family, Mutation, Signal Transduction, Transforming Growth Factor beta
Added February 21, 2017
0 Communities
1 Members
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14 MeSH Terms
Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
McCulloch KM, McCranie EK, Smith JA, Sarwar M, Mathieu JL, Gitschlag BL, Du Y, Bachmann BO, Iverson TM
(2015) Proc Natl Acad Sci U S A 112: 11547-52
MeSH Terms: Aminoglycosides, Anti-Bacterial Agents, Catalytic Domain, Crystallography, X-Ray, Cyclization, Hydrogen, Hygromycin B, Metals, Micromonospora, Multigene Family, Oligosaccharides, Open Reading Frames, Oxidation-Reduction, Oxygen, Oxygenases, Phylogeny, Protein Binding, Protein Structure, Secondary, Reproducibility of Results, Streptomyces
Added April 1, 2019
0 Communities
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MeSH Terms
Introduction: Metals in Biology: α-Ketoglutarate/Iron-Dependent Dioxygenases.
Guengerich FP
(2015) J Biol Chem 290: 20700-20701
MeSH Terms: 5-Methylcytosine, AlkB Homolog 4, Lysine Demethylase, DNA, DNA Damage, DNA Repair, Dioxygenases, Epigenesis, Genetic, Gene Expression, Humans, Iron, Isoenzymes, Ketoglutaric Acids, Multigene Family, Oxidation-Reduction, Protein Processing, Post-Translational, Thymine
Added March 14, 2018
0 Communities
1 Members
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16 MeSH Terms