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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 46

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Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.
Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T
(2019) JCI Insight 4:
MeSH Terms: Animals, Carcinogenesis, Cell Line, Tumor, Cell Proliferation, Cells, Cultured, Colitis, Ulcerative, Colon, Colorectal Neoplasms, Dextran Sulfate, Disease Models, Animal, Female, Humans, Intestinal Mucosa, Kaplan-Meier Estimate, Macrophages, Male, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Transgenic, Morpholines, Osteopontin, Primary Cell Culture, Prognosis, Survival Rate
Added November 6, 2019
1 Communities
1 Members
0 Resources
24 MeSH Terms
The discovery of VU0486846: steep SAR from a series of M PAMs based on a novel benzomorpholine core.
Bertron JL, Cho HP, Garcia-Barrantes PM, Panarese JD, Salovich JM, Nance KD, Engers DW, Rook JM, Blobaum AL, Niswender CM, Stauffer SR, Conn PJ, Lindsley CW
(2018) Bioorg Med Chem Lett 28: 2175-2179
MeSH Terms: Animals, CHO Cells, Cricetulus, Drug Discovery, Humans, Molecular Structure, Morpholines, Pyrazoles, Rats, Receptor, Muscarinic M1, Structure-Activity Relationship
Added March 3, 2020
0 Communities
2 Members
0 Resources
MeSH Terms
A Novel M PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity.
Rook JM, Bertron JL, Cho HP, Garcia-Barrantes PM, Moran SP, Maksymetz JT, Nance KD, Dickerson JW, Remke DH, Chang S, Harp JM, Blobaum AL, Niswender CM, Jones CK, Stauffer SR, Conn PJ, Lindsley CW
(2018) ACS Chem Neurosci 9: 2274-2285
MeSH Terms: Allosteric Regulation, Animals, Antipsychotic Agents, CHO Cells, Cognition, Cognitive Dysfunction, Conditioning, Psychological, Cricetulus, Exploratory Behavior, Fear, Mice, Morpholines, Prefrontal Cortex, Pyrazoles, Rats, Risperidone, Seizures
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line.
Bryan MR, Uhouse MA, Nordham KD, Joshi P, Rose DIR, O'Brien MT, Aschner M, Bowman AB
(2018) Neurotoxicology 64: 185-194
MeSH Terms: Animals, Cell Line, Chromones, Corpus Striatum, HEK293 Cells, Homeostasis, Humans, Induced Pluripotent Stem Cells, Inhibitory Concentration 50, Manganese, Mice, Morpholines, Neural Stem Cells, Phosphatidylinositol 3-Kinase, Signal Transduction, Tumor Suppressor Protein p53
Added April 11, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms
PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses.
Sai J, Owens P, Novitskiy SV, Hawkins OE, Vilgelm AE, Yang J, Sobolik T, Lavender N, Johnson AC, McClain C, Ayers GD, Kelley MC, Sanders M, Mayer IA, Moses HL, Boothby M, Richmond A
(2017) Clin Cancer Res 23: 3371-3384
MeSH Terms: Aminopyridines, Animals, Cell Line, Tumor, Cell Proliferation, Class Ib Phosphatidylinositol 3-Kinase, Female, Humans, Immunity, Cellular, Mammary Neoplasms, Animal, Mice, Morpholines, Neoplasm Metastasis, Phosphoinositide-3 Kinase Inhibitors, Programmed Cell Death 1 Receptor, Protein Kinase Inhibitors, Signal Transduction, Triple Negative Breast Neoplasms, Xenograft Model Antitumor Assays
Added January 4, 2017
2 Communities
4 Members
0 Resources
18 MeSH Terms
Inflammatory cytokine TSLP stimulates platelet secretion and potentiates platelet aggregation via a TSLPR-dependent PI3K/Akt signaling pathway.
Dong J, Dong J, Lin J, Wang B, He S, Wu C, Kushwaha KK, Mohabeer N, Su Y, Fang H, Huang K, Li D
(2015) Cell Physiol Biochem 35: 160-74
MeSH Terms: Androstadienes, Animals, Blood Platelets, Carotid Artery Thrombosis, Chlorides, Chromones, Cytokines, Disease Models, Animal, Ferric Compounds, Humans, Immunoglobulins, Mice, Mice, Inbred C57BL, Mice, Knockout, Morpholines, P-Selectin, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Platelet Activation, Platelet Aggregation, Platelet Glycoprotein GPIIb-IIIa Complex, Proto-Oncogene Proteins c-akt, Receptors, Cytokine, Signal Transduction, Wortmannin
Added January 20, 2015
0 Communities
1 Members
0 Resources
26 MeSH Terms
LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer.
Schwarz LJ, Fox EM, Balko JM, Garrett JT, Kuba MG, Estrada MV, González-Angulo AM, Mills GB, Red-Brewer M, Mayer IA, Abramson V, Rizzo M, Kelley MC, Meszoely IM, Arteaga CL
(2014) J Clin Invest 124: 5490-502
MeSH Terms: Amino Acid Substitution, Aminopyridines, Animals, Breast Neoplasms, Dasatinib, Drug Resistance, Neoplasm, Drug Synergism, Estrogen Receptor Modulators, Female, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Mice, Mice, Nude, Morpholines, Mutation, Missense, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Protein Kinase Inhibitors, Pyrimidines, Receptors, Estrogen, Thiazoles, Xenograft Model Antitumor Assays, src Homology Domains, src-Family Kinases
Added February 16, 2016
0 Communities
2 Members
0 Resources
26 MeSH Terms
Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.
Mayer IA, Abramson VG, Isakoff SJ, Forero A, Balko JM, Kuba MG, Sanders ME, Yap JT, Van den Abbeele AD, Li Y, Cantley LC, Winer E, Arteaga CL
(2014) J Clin Oncol 32: 1202-9
MeSH Terms: Adult, Aged, Aminopyridines, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Cell Line, Tumor, Class I Phosphatidylinositol 3-Kinases, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Fluorodeoxyglucose F18, Humans, Letrozole, Middle Aged, Morpholines, Multimodal Imaging, Nitriles, Phosphoinositide-3 Kinase Inhibitors, Positron-Emission Tomography, Protein Kinase Inhibitors, Radiopharmaceuticals, Receptor, ErbB-2, Receptors, Estrogen, Tomography, X-Ray Computed, Triazoles
Added March 27, 2014
0 Communities
3 Members
0 Resources
26 MeSH Terms
Response to letter regarding article 'Exploring the link between pholcodine exposure and neuromuscular blocking agent anaphylaxis'.
Brusch AM, Clarke RC, Platt PR, Phillips E
(2014) Br J Clin Pharmacol 78: 931-2
MeSH Terms: Allergens, Ammonium Compounds, Anaphylaxis, Codeine, Drug Hypersensitivity, Humans, Morpholines, Neuromuscular Blocking Agents
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
NBTI 5463 is a novel bacterial type II topoisomerase inhibitor with activity against gram-negative bacteria and in vivo efficacy.
Dougherty TJ, Nayar A, Newman JV, Hopkins S, Stone GG, Johnstone M, Shapiro AB, Cronin M, Reck F, Ehmann DE
(2014) Antimicrob Agents Chemother 58: 2657-64
MeSH Terms: Anti-Bacterial Agents, DNA Gyrase, DNA Topoisomerase IV, Escherichia coli, Fluoroquinolones, Gram-Negative Bacteria, Microbial Sensitivity Tests, Morpholines, Naphthyridines, Topoisomerase II Inhibitors
Added March 20, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms