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Results: 1 to 10 of 126

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Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone.
Reddish MJ, Guengerich FP
(2019) J Biol Chem 294: 12975-12991
MeSH Terms: 18-Hydroxycorticosterone, Aldosterone, Biocatalysis, Cytochrome P-450 CYP11B2, Humans, Kinetics, Models, Molecular, Molecular Conformation
Added March 3, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes.
Guengerich FP, Wilkey CJ, Phan TTN
(2019) J Biol Chem 294: 10928-10941
MeSH Terms: Catalysis, Cytochrome P-450 CYP2D6, Cytochrome P-450 CYP2E1, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Kinetics, Lauric Acids, Ligands, Molecular Conformation, Oxidation-Reduction, Palmitic Acid, Protein Binding, Protein Conformation, Spiro Compounds, Substrate Specificity
Added March 3, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Isomeric and Conformational Analysis of Small Drug and Drug-Like Molecules by Ion Mobility-Mass Spectrometry (IM-MS).
Phillips ST, Dodds JN, May JC, McLean JA
(2019) Methods Mol Biol 1939: 161-178
MeSH Terms: Algorithms, Amino Acids, Carbohydrates, Ion Mobility Spectrometry, Isomerism, Mass Spectrometry, Molecular Conformation, Pharmaceutical Preparations, Small Molecule Libraries, Software
Added August 7, 2019
1 Communities
0 Members
0 Resources
MeSH Terms
Ion mobility conformational lipid atlas for high confidence lipidomics.
Leaptrot KL, May JC, Dodds JN, McLean JA
(2019) Nat Commun 10: 985
MeSH Terms: Animals, Databases, Chemical, Lipids, Mass Spectrometry, Metabolomics, Molecular Conformation, Molecular Structure
Added August 7, 2019
1 Communities
0 Members
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MeSH Terms
Absolute Configurations of Naturally Occurring [5]- and [3]-Ladderanoic Acids: Isolation, Chiroptical Spectroscopy, and Crystallography.
Raghavan V, Johnson JL, Stec DF, Song B, Zajac G, Baranska M, Harris CM, Schley ND, Polavarapu PL, Harris TM
(2018) J Nat Prod 81: 2654-2666
MeSH Terms: Biomass, Bioreactors, Circular Dichroism, Crystallography, X-Ray, Esters, Lipids, Molecular Conformation, Molecular Structure, Spectrum Analysis, Raman, Stereoisomerism
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Movement of the RecG Motor Domain upon DNA Binding Is Required for Efficient Fork Reversal.
Warren GM, Stein RA, Mchaourab HS, Eichman BF
(2018) Int J Mol Sci 19:
MeSH Terms: DNA, DNA Helicases, DNA Replication, DNA-Binding Proteins, Models, Molecular, Molecular Conformation, Mutation, Nucleic Acid Conformation, Protein Binding, Protein Interaction Domains and Motifs, Structure-Activity Relationship
Added August 26, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Absolute configuration of an axially chiral sulfonate determined from its optical rotatory dispersion, electronic circular dichroism, and vibrational circular dichroism spectra.
Covington CL, Raghavan V, Smuts JP, Armstrong DW, Polavarapu PL
(2017) Chirality 29: 670-676
MeSH Terms: Circular Dichroism, Models, Molecular, Molecular Conformation, Naphthalenes, Optical Rotatory Dispersion, Stereoisomerism, Sulfonic Acids, Vibration
Added April 10, 2018
0 Communities
1 Members
0 Resources
8 MeSH Terms
Investigation of the Complete Suite of the Leucine and Isoleucine Isomers: Toward Prediction of Ion Mobility Separation Capabilities.
Dodds JN, May JC, McLean JA
(2017) Anal Chem 89: 952-959
MeSH Terms: Isoleucine, Isomerism, Leucine, Mass Spectrometry, Molecular Conformation
Added December 17, 2018
0 Communities
1 Members
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MeSH Terms
Atropoisomerism in Biflavones: The Absolute Configuration of (-)-Agathisflavone via Chiroptical Spectroscopy.
Covington CL, Junior FM, Silva JH, Kuster RM, de Amorim MB, Polavarapu PL
(2016) J Nat Prod 79: 2530-2537
MeSH Terms: Biflavonoids, Circular Dichroism, Molecular Conformation, Molecular Structure, Optical Rotatory Dispersion, Stereoisomerism
Added April 10, 2018
0 Communities
1 Members
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MeSH Terms
Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ.
Kim JK, Yeom M, Hong JK, Song I, Lee YS, Guengerich FP, Choi JY
(2016) Chem Res Toxicol 29: 1741-1754
MeSH Terms: DNA-Directed DNA Polymerase, Genetic Variation, Humans, Models, Molecular, Molecular Conformation
Added March 14, 2018
0 Communities
1 Members
0 Resources
5 MeSH Terms