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Immunity drives regulation in cancer through NF-κB.
Collignon E, Canale A, Al Wardi C, Bizet M, Calonne E, Dedeurwaerder S, Garaud S, Naveaux C, Barham W, Wilson A, Bouchat S, Hubert P, Van Lint C, Yull F, Sotiriou C, Willard-Gallo K, Noel A, Fuks F
(2018) Sci Adv 4: eaap7309
MeSH Terms: Adaptive Immunity, Biomarkers, DNA Methylation, Epigenesis, Genetic, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Immunity, Immunity, Innate, Mixed Function Oxygenases, NF-kappa B, Neoplasms, Neoplasms, Basal Cell, Promoter Regions, Genetic, Protein Binding, Proto-Oncogene Proteins
Added March 31, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Fur regulation of Staphylococcus aureus heme oxygenases is required for heme homeostasis.
Lojek LJ, Farrand AJ, Weiss A, Skaar EP
(2018) Int J Med Microbiol 308: 582-589
MeSH Terms: Aerobiosis, Bacterial Proteins, Gene Expression Regulation, Bacterial, Heme, Heme Oxygenase (Decyclizing), Homeostasis, Iron, Mixed Function Oxygenases, Oxygenases, Repressor Proteins, Staphylococcus aureus
Added March 15, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins.
Zdżalik D, Domańska A, Prorok P, Kosicki K, van den Born E, Falnes PØ, Rizzo CJ, Guengerich FP, Tudek B
(2015) DNA Repair (Amst) 30: 1-10
MeSH Terms: Adenine, AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase, AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase, Bacteria, Bacterial Proteins, Cytosine, DNA, DNA Adducts, DNA Glycosylases, DNA Repair, DNA Repair Enzymes, DNA, Single-Stranded, Dioxygenases, Escherichia coli, Escherichia coli Proteins, Guanine, Humans, Mixed Function Oxygenases, Mycobacterium tuberculosis, Rhizobium etli, Streptomyces, Substrate Specificity, Xanthomonas campestris
Added January 7, 2016
0 Communities
2 Members
0 Resources
23 MeSH Terms
Mechanism of repair of acrolein- and malondialdehyde-derived exocyclic guanine adducts by the α-ketoglutarate/Fe(II) dioxygenase AlkB.
Singh V, Fedeles BI, Li D, Delaney JC, Kozekov ID, Kozekova A, Marnett LJ, Rizzo CJ, Essigmann JM
(2014) Chem Res Toxicol 27: 1619-31
MeSH Terms: Acrolein, Borohydrides, Chromatography, High Pressure Liquid, DNA, DNA Adducts, DNA Repair, DNA, Single-Stranded, Deoxyguanosine, Escherichia coli Proteins, Malondialdehyde, Mixed Function Oxygenases, Oligonucleotides, Tandem Mass Spectrometry
Added January 7, 2016
0 Communities
2 Members
0 Resources
13 MeSH Terms
An open-source analytical platform for analysis of C. elegans swimming-induced paralysis.
Hardaway JA, Wang J, Fleming PA, Fleming KA, Whitaker SM, Nackenoff A, Snarrenberg CL, Hardie SL, Zhang B, Blakely RD
(2014) J Neurosci Methods 232: 58-62
MeSH Terms: Analysis of Variance, Animals, Animals, Genetically Modified, Antidepressive Agents, Tricyclic, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Dopamine Plasma Membrane Transport Proteins, Dose-Response Relationship, Drug, Electronic Data Processing, Imipramine, Mixed Function Oxygenases, Mutation, Paralysis, Receptors, Dopamine D2, Swimming
Added May 21, 2014
0 Communities
2 Members
0 Resources
15 MeSH Terms
Obesity-associated variants within FTO form long-range functional connections with IRX3.
Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA
(2014) Nature 507: 371-5
MeSH Terms: Adipose Tissue, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Animals, Basal Metabolism, Body Mass Index, Body Weight, Brain, Diabetes Mellitus, Type 2, Diet, Genes, Dominant, Homeodomain Proteins, Humans, Hypothalamus, Introns, Male, Mice, Mixed Function Oxygenases, Obesity, Oxo-Acid-Lyases, Phenotype, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Proteins, Thinness, Transcription Factors, Zebrafish
Added February 22, 2016
0 Communities
2 Members
0 Resources
26 MeSH Terms
Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.
Blobaum AL, Bridges TM, Byers FW, Turlington ML, Mattmann ME, Morrison RD, Mackie C, Lavreysen H, Bartolomé JM, Macdonald GJ, Steckler T, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR, Daniels JS
(2013) Drug Metab Dispos 41: 2066-75
MeSH Terms: Allosteric Regulation, Animals, Cytochrome P-450 CYP3A, Drug Interactions, Hepatocytes, Humans, Intestinal Mucosa, Intestines, Ketoconazole, Kinetics, Liver, Male, Mice, Microsomes, Microsomes, Liver, Midazolam, Mixed Function Oxygenases, Rats, Rats, Sprague-Dawley
Added February 19, 2015
0 Communities
3 Members
0 Resources
19 MeSH Terms
Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
Perera MA, Cavallari LH, Limdi NA, Gamazon ER, Konkashbaev A, Daneshjou R, Pluzhnikov A, Crawford DC, Wang J, Liu N, Tatonetti N, Bourgeois S, Takahashi H, Bradford Y, Burkley BM, Desnick RJ, Halperin JL, Khalifa SI, Langaee TY, Lubitz SA, Nutescu EA, Oetjens M, Shahin MH, Patel SR, Sagreiya H, Tector M, Weck KE, Rieder MJ, Scott SA, Wu AH, Burmester JK, Wadelius M, Deloukas P, Wagner MJ, Mushiroda T, Kubo M, Roden DM, Cox NJ, Altman RB, Klein TE, Nakamura Y, Johnson JA
(2013) Lancet 382: 790-6
MeSH Terms: African Americans, Alleles, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C9, Female, Genome-Wide Association Study, Genotype, Humans, Male, Mixed Function Oxygenases, Polymorphism, Single Nucleotide, Vitamin K Epoxide Reductases, Warfarin
Added March 7, 2014
0 Communities
3 Members
0 Resources
14 MeSH Terms
Warfarin pharmacogenomics in children.
Vear SI, Stein CM, Ho RH
(2013) Pediatr Blood Cancer 60: 1402-7
MeSH Terms: Adolescent, Adult, Algorithms, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Child, Child, Preschool, Cytochrome P-450 CYP2C9, Female, Humans, International Normalized Ratio, Male, Mixed Function Oxygenases, Pharmacogenetics, Vitamin K Epoxide Reductases, Warfarin
Added March 5, 2014
1 Communities
1 Members
0 Resources
16 MeSH Terms
A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism.
Celestino-Soper PB, Violante S, Crawford EL, Luo R, Lionel AC, Delaby E, Cai G, Sadikovic B, Lee K, Lo C, Gao K, Person RE, Moss TJ, German JR, Huang N, Shinawi M, Treadwell-Deering D, Szatmari P, Roberts W, Fernandez B, Schroer RJ, Stevenson RE, Buxbaum JD, Betancur C, Scherer SW, Sanders SJ, Geschwind DH, Sutcliffe JS, Hurles ME, Wanders RJ, Shaw CA, Leal SM, Cook EH, Goin-Kochel RP, Vaz FM, Beaudet AL
(2012) Proc Natl Acad Sci U S A 109: 7974-81
MeSH Terms: Autistic Disorder, Carnitine, Chromosomes, Human, X, Cognition, Exons, Gene Deletion, Genes, X-Linked, Humans, Male, Metabolism, Inborn Errors, Mixed Function Oxygenases, Penetrance, Risk Factors, Siblings
Added February 20, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms