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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 224

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Apoptosis signal-regulating kinase 1 (ASK1) inhibition reduces endothelial cytokine production without improving permeability after toll-like receptor 4 (TLR4) challenge.
Miller MR, Koch SR, Choi H, Lamb FS, Stark RJ
(2021) Transl Res 235: 115-128
MeSH Terms: Cells, Cultured, Cytokines, Endothelial Cells, Humans, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase Kinase 5, MAP Kinase Signaling System, Nitric Oxide Synthase Type III, Permeability, Toll-Like Receptor 4, p38 Mitogen-Activated Protein Kinases
Added April 16, 2021
0 Communities
1 Members
0 Resources
11 MeSH Terms
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.
Fischer K, Fenzl A, Liu D, Dyar KA, Kleinert M, Brielmeier M, Clemmensen C, Fedl A, Finan B, Gessner A, Jastroch M, Huang J, Keipert S, Klingenspor M, Brüning JC, Kneilling M, Maier FC, Othman AE, Pichler BJ, Pramme-Steinwachs I, Sachs S, Scheideler A, Thaiss WM, Uhlenhaut H, Ussar S, Woods SC, Zorn J, Stemmer K, Collins S, Diaz-Meco M, Moscat J, Tschöp MH, Müller TD
(2020) Nat Commun 11: 2306
MeSH Terms: Activating Transcription Factor 2, Adipogenesis, Adipose Tissue, Brown, Adipose Tissue, White, Animals, Cell Nucleus, Magnetic Resonance Imaging, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Obesity, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Positron Emission Tomography Computed Tomography, Protein Binding, Sequestosome-1 Protein, Uncoupling Protein 1, p38 Mitogen-Activated Protein Kinases
Added July 22, 2020
0 Communities
1 Members
0 Resources
18 MeSH Terms
Normal Saline solutions cause endothelial dysfunction through loss of membrane integrity, ATP release, and inflammatory responses mediated by P2X7R/p38 MAPK/MK2 signaling pathways.
Cheung-Flynn J, Alvis BD, Hocking KM, Guth CM, Luo W, McCallister R, Chadalavada K, Polcz M, Komalavilas P, Brophy CM
(2019) PLoS One 14: e0220893
MeSH Terms: Adenosine Triphosphate, Animals, Aorta, Cell Membrane, Endothelial Cells, Humans, Inflammation, Intracellular Signaling Peptides and Proteins, Phosphorylation, Protein Serine-Threonine Kinases, Rats, Receptors, Purinergic P2X7, Saline Solution, Saphenous Vein, Signal Transduction, Swine, p38 Mitogen-Activated Protein Kinases
Added March 3, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Generating kinetic environments to study dynamic cellular processes in single cells.
Thiemicke A, Jashnsaz H, Li G, Neuert G
(2019) Sci Rep 9: 10129
MeSH Terms: Algorithms, Cell Line, Cell Shape, Equipment Design, Gene Expression Regulation, Humans, In Situ Hybridization, Fluorescence, Interrupted Time Series Analysis, Kinetics, Membrane Transport Proteins, Mitogen-Activated Protein Kinases, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Signal Transduction, Single Molecule Imaging, Single-Cell Analysis, Time-Lapse Imaging
Added February 5, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Toll-like receptor 3-mediated inflammation by p38 is enhanced by endothelial nitric oxide synthase knockdown.
Koch SR, Choi H, Mace EH, Stark RJ
(2019) Cell Commun Signal 17: 33
MeSH Terms: Capillary Permeability, Cells, Cultured, Chemokine CXCL10, Endothelium, Vascular, Gene Knockdown Techniques, Humans, Inflammation, Interleukin-6, Interleukin-8, Nitric Oxide Synthase Type III, Poly I-C, RNA, Small Interfering, Toll-Like Receptor 3, p38 Mitogen-Activated Protein Kinases
Added April 17, 2019
0 Communities
1 Members
0 Resources
14 MeSH Terms
Activation of Nrf2 attenuates delayed gastric emptying in obesity induced diabetic (T2DM) female mice.
Sampath C, Sprouse JC, Freeman ML, Gangula PR
(2019) Free Radic Biol Med 135: 132-143
MeSH Terms: Acrolein, Animals, Antioxidants, Diabetes Complications, Diabetes Mellitus, Type 2, Diet, High-Fat, Gastric Emptying, Gastroparesis, Humans, MAP Kinase Signaling System, Mice, Muscle Relaxation, NF-E2-Related Factor 2, Nitric Oxide Synthase Type I, Obesity, Stomach, p38 Mitogen-Activated Protein Kinases
Added March 3, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
Heterologous phosphorylation-induced formation of a stability lock permits regulation of inactive receptors by β-arrestins.
Tóth AD, Prokop S, Gyombolai P, Várnai P, Balla A, Gurevich VV, Hunyady L, Turu G
(2018) J Biol Chem 293: 876-892
MeSH Terms: Angiotensin II, Animals, COS Cells, Chlorocebus aethiops, HEK293 Cells, Humans, Immunoblotting, Microscopy, Confocal, Mitogen-Activated Protein Kinases, Phosphorylation, Receptors, G-Protein-Coupled, beta-Arrestins
Added March 14, 2018
0 Communities
1 Members
0 Resources
12 MeSH Terms
Vascular surgical stretch injury leads to activation of P2X7 receptors and impaired endothelial function.
Komalavilas P, Luo W, Guth CM, Jolayemi O, Bartelson RI, Cheung-Flynn J, Brophy CM
(2017) PLoS One 12: e0188069
MeSH Terms: Animals, Endothelium, Vascular, Female, Nitric Oxide, Phosphorylation, Rats, Rats, Sprague-Dawley, Receptors, Purinergic P2X7, Vascular Surgical Procedures, p38 Mitogen-Activated Protein Kinases
Added May 22, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Endothelial nitric oxide synthase modulates Toll-like receptor 4-mediated IL-6 production and permeability via nitric oxide-independent signaling.
Stark RJ, Koch SR, Choi H, Mace EH, Dikalov SI, Sherwood ER, Lamb FS
(2018) FASEB J 32: 945-956
MeSH Terms: Capillary Permeability, Cells, Cultured, Chronic Disease, Endothelial Cells, Gene Expression Regulation, Enzymologic, Humans, Imidazoles, Interleukin-6, Lipopolysaccharides, MAP Kinase Signaling System, Nitric Oxide, Nitric Oxide Synthase Type III, Pyridines, Toll-Like Receptor 4, Vasculitis, p38 Mitogen-Activated Protein Kinases
Added October 27, 2017
0 Communities
3 Members
0 Resources
16 MeSH Terms
Adenosine triphosphate as a molecular mediator of the vascular response to injury.
Guth CM, Luo W, Jolayemi O, Chadalavada KS, Komalavilas P, Cheung-Flynn J, Brophy CM
(2017) J Surg Res 216: 80-86
MeSH Terms: Adenosine Triphosphate, Animals, Aorta, Abdominal, Biomarkers, Biomechanical Phenomena, Blotting, Western, Female, Muscle Contraction, Rats, Rats, Sprague-Dawley, Receptors, Purinergic P2X7, Stress, Mechanical, Vascular System Injuries, p38 Mitogen-Activated Protein Kinases
Added May 22, 2018
0 Communities
1 Members
0 Resources
MeSH Terms