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Results: 1 to 6 of 6

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Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.
Babaev VR, Yeung M, Erbay E, Ding L, Zhang Y, May JM, Fazio S, Hotamisligil GS, Linton MF
(2016) Arterioscler Thromb Vasc Biol 36: 1122-31
MeSH Terms: Animals, Aorta, Aortic Diseases, Apoptosis, Atherosclerosis, Bone Marrow Cells, Bone Marrow Transplantation, Cell Survival, Cells, Cultured, Diet, High-Fat, Disease Models, Animal, Endoplasmic Reticulum Stress, Genetic Predisposition to Disease, Hypercholesterolemia, Macrophages, Mice, Inbred C57BL, Mice, Knockout, Mitogen-Activated Protein Kinase 8, Mitogen-Activated Protein Kinase 9, PTEN Phosphohydrolase, Phenotype, Plaque, Atherosclerotic, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Receptors, LDL, Signal Transduction, bcl-Associated Death Protein
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding.
Kook S, Zhan X, Kaoud TS, Dalby KN, Gurevich VV, Gurevich EV
(2013) J Biol Chem 288: 37332-42
MeSH Terms: Animals, Arrestins, COS Cells, Cell Proliferation, Cell Survival, Chlorocebus aethiops, Enzyme Activation, Isoenzymes, MAP Kinase Kinase 7, MAP Kinase Kinase Kinase 5, MAP Kinase Signaling System, Mice, Mice, Knockout, Mitogen-Activated Protein Kinase 8, Mitogen-Activated Protein Kinase 9, Phosphorylation, Protein Binding
Added February 12, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury.
Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV
(2010) Nat Med 16: 535-43, 1p following 143
MeSH Terms: Acute Kidney Injury, Adult, Cell Cycle, Epithelial Cells, Fibrosis, Glomerulonephritis, Humans, Kidney, Kidney Diseases, Mitogen-Activated Protein Kinase 9, Tumor Suppressor Protein p53
Added September 12, 2016
0 Communities
1 Members
0 Resources
11 MeSH Terms
Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1.
Muraoka-Cook RS, Caskey LS, Sandahl MA, Hunter DM, Husted C, Strunk KE, Sartor CI, Rearick WA, McCall W, Sgagias MK, Cowan KH, Earp HS
(2006) Mol Cell Biol 26: 6412-24
MeSH Terms: Animals, BRCA1 Protein, Breast Neoplasms, Epithelial Cells, ErbB Receptors, Exons, G2 Phase, Gene Expression Regulation, Neoplastic, HeLa Cells, Humans, Mammary Glands, Animal, Mice, Mitogen-Activated Protein Kinase 8, Mitogen-Activated Protein Kinase 9, Mitosis, Neuregulin-1, RNA, Messenger, Receptor, ErbB-2, Receptor, ErbB-4, Tumor Cells, Cultured
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes.
Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P
(2003) Mol Cell Biol 23: 3052-66
MeSH Terms: Amino Acid Sequence, Animals, Apoptosis, Bile Acids and Salts, CASP8 and FADD-Like Apoptosis Regulating Protein, CCAAT-Enhancer-Binding Proteins, Carrier Proteins, Cell Survival, Cells, Cultured, Cyclic AMP Response Element-Binding Protein, Deoxycholic Acid, Enzyme Inhibitors, Hepatocytes, Intracellular Signaling Peptides and Proteins, JNK Mitogen-Activated Protein Kinases, Male, Mice, Mice, Inbred C57BL, Mitogen-Activated Protein Kinase 9, Mitogen-Activated Protein Kinases, Molecular Sequence Data, Rats, Rats, Sprague-Dawley, Signal Transduction, Transcription Factor AP-1, fas Receptor
Added March 5, 2014
0 Communities
1 Members
0 Resources
26 MeSH Terms
Tumor necrosis factor-alpha induction of endothelial ephrin A1 expression is mediated by a p38 MAPK- and SAPK/JNK-dependent but nuclear factor-kappa B-independent mechanism.
Cheng N, Chen J
(2001) J Biol Chem 276: 13771-7
MeSH Terms: Adenoviridae, Antigens, CD, Blotting, Northern, Blotting, Western, Cells, Cultured, Dose-Response Relationship, Drug, Electrophoresis, Polyacrylamide Gel, Endothelium, Vascular, Enzyme Activation, Enzyme Inhibitors, Ephrin-A1, Flavonoids, Gene Expression Regulation, Enzymologic, Genes, Dominant, Humans, Kinetics, Ligands, Mitogen-Activated Protein Kinase 9, Mitogen-Activated Protein Kinases, Models, Biological, NF-kappa B, Phosphotransferases, Protein Biosynthesis, Protein Isoforms, Receptors, Tumor Necrosis Factor, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, Signal Transduction, Time Factors, Tumor Necrosis Factor-alpha, Umbilical Cord, Up-Regulation, p38 Mitogen-Activated Protein Kinases
Added March 5, 2014
1 Communities
1 Members
0 Resources
33 MeSH Terms