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Subclinical Atherosclerosis, Statin Eligibility, and Outcomes in African American Individuals: The Jackson Heart Study.
Shah RV, Spahillari A, Mwasongwe S, Carr JJ, Terry JG, Mentz RJ, Addison D, Hoffmann U, Reis J, Freedman JE, Lima JAC, Correa A, Murthy VL
(2017) JAMA Cardiol 2: 644-652
MeSH Terms: Adult, African Americans, Aged, Aorta, Abdominal, Atherosclerosis, Coronary Artery Disease, Eligibility Determination, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Incidence, Male, Middle Aged, Mississippi, Practice Guidelines as Topic, Prospective Studies, Risk Assessment, Tomography, X-Ray Computed, Vascular Calcification
Show Abstract · Added September 11, 2017
Importance - Modern prevention guidelines substantially increase the number of individuals who are eligible for treatment with statins. Efforts to refine statin eligibility via coronary calcification have been studied in white populations but not, to our knowledge, in large African American populations.
Objective - To compare the relative accuracy of US Preventive Services Task Force (USPSTF) and American College of Cardiology/American Heart Association (ACC/AHA) recommendations in identifying African American individuals with subclinical and clinical atherosclerotic cardiovascular disease (ASCVD).
Design, Setting, and Participants - In this prospective, community-based study, 2812 African American individuals aged 40 to 75 years without prevalent ASCVD underwent assessment of ASCVD risk. Of these, 1743 participants completed computed tomography.
Main Outcomes and Measures - Nonzero coronary artery calcium (CAC) score, abdominal aortic calcium score, and incident ASCVD (ie, myocardial infarction, ischemic stroke, or fatal coronary heart disease).
Results - Of the 2812 included participants, the mean (SD) age at baseline was 55.4 (9.4) years, and 1837 (65.3%) were female. The USPSTF guidelines captured 404 of 732 African American individuals (55.2%) with a CAC score greater than 0; the ACC/AHA guidelines identified 507 individuals (69.3%) (risk difference, 14.1%; 95% CI, 11.2-17.0; P < .001). Statin recommendation under both guidelines was associated with a CAC score greater than 0 (odds ratio, 5.1; 95% CI, 4.1-6.3; P < .001). While individuals indicated for statins under both guidelines experienced 9.6 cardiovascular events per 1000 patient-years, those indicated under only ACC/AHA guidelines were at low to intermediate risk (4.1 events per 1000 patient-years). Among individuals who were statin eligible by ACC/AHA guidelines, the 10-year ASCVD incidence per 1000 person-years was 8.1 (95% CI, 5.9-11.1) in the presence of CAC and 3.1 (95% CI, 1.6-5.9) without CAC (P = .02). While statin-eligible individuals by USPSTF guidelines did not have a significantly higher 10-year ASCVD event rate in the presence of CAC, African American individuals not eligible for statins by USPSTF guidelines had a higher ASCVD event rate in the presence of CAC (2.8 per 1000 person-years; 95% CI, 1.5-5.4) relative to without CAC (0.8 per 1000 person-years; 95%, CI 0.3-1.7) (P = .03).
Conclusions and Relevance - The USPSTF guidelines focus treatment recommendations on 38% of high-risk African American individuals at the expense of not recommending treatment in nearly 25% of African American individuals eligible for statins by ACC/AHA guidelines with vascular calcification and at low to intermediate ASCVD risk.
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19 MeSH Terms
Ideal Cardiovascular Health, Cardiovascular Remodeling, and Heart Failure in Blacks: The Jackson Heart Study.
Spahillari A, Talegawkar S, Correa A, Carr JJ, Terry JG, Lima J, Freedman JE, Das S, Kociol R, de Ferranti S, Mohebali D, Mwasongwe S, Tucker KL, Murthy VL, Shah RV
(2017) Circ Heart Fail 10:
MeSH Terms: Adult, African Americans, Aged, Blood Glucose, Blood Pressure, Comorbidity, Diabetes Mellitus, Exercise, Female, Health Status Disparities, Heart Failure, Humans, Hypertension, Incidence, Kaplan-Meier Estimate, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Mississippi, Prospective Studies, Risk Assessment, Risk Factors, Risk Reduction Behavior, Sedentary Behavior, Smoking, Smoking Cessation, Smoking Prevention, Ventricular Function, Left, Ventricular Remodeling
Show Abstract · Added September 11, 2017
BACKGROUND - The lifetime risk of heart failure (HF) is higher in the black population than in other racial groups in the United States.
METHODS AND RESULTS - We measured the Life's Simple 7 ideal cardiovascular health metrics in 4195 blacks in the JHS (Jackson Heart Study; 2000-2004). We evaluated the association of Simple 7 metrics with incident HF and left ventricular structure and function by cardiac magnetic resonance (n=1188). Mean age at baseline was 54.4 years (65% women). Relative to 0 to 2 Simple 7 factors, blacks with 3 factors had 47% lower incident HF risk (hazard ratio [HR], 0.53; 95% confidence interval [CI], 0.39-0.73; <0.0001); and those with ≥4 factors had 61% lower HF risk (HR, 0.39; 95% CI, 0.24-0.64; =0.0002). Higher blood pressure (HR, 2.32; 95% CI, 1.28-4.20; =0.005), physical inactivity (HR, 1.65; 95% CI, 1.07-2.55; =0.02), smoking (HR, 2.04; 95% CI, 1.43-2.91; <0.0001), and impaired glucose control (HR, 1.76; 95% CI, 1.34-2.29; <0.0001) were associated with incident HF. The age-/sex-adjusted population attributable risk for these Simple 7 metrics combined was 37.1%. Achievement of ideal blood pressure, ideal body mass index, ideal glucose control, and nonsmoking was associated with less likelihood of adverse cardiac remodeling by cardiac magnetic resonance.
CONCLUSIONS - Cardiovascular risk factors in midlife (specifically elevated blood pressure, physical inactivity, smoking, and poor glucose control) are associated with incident HF in blacks and represent targets for intensified HF prevention.
© 2017 American Heart Association, Inc.
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29 MeSH Terms
Sex, weight status, and chronic kidney disease among African Americans: the Jackson Heart Study.
Bruce MA, Beech BM, Crook ED, Sims M, Griffith DM, Simpson SL, Ard J, Norris KC
(2013) J Investig Med 61: 701-7
MeSH Terms: Adult, African Americans, Aged, Aged, 80 and over, Body Mass Index, Body Weight, Cohort Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Mississippi, Obesity, Odds Ratio, Renal Insufficiency, Chronic, Risk Factors, Sex Factors, Urban Health, Young Adult
Show Abstract · Added March 27, 2014
BACKGROUND - Obesity has been shown to have implications for chronic kidney disease (CKD); however, it has received minimal attention from scientists studying CKD among African Americans.
OBJECTIVES - The purpose of this study was to examine the manner in which weight status has implications for CKD among this group through analysis of data drawn from the Jackson Heart Study (JHS).
DESIGN - Cross-sectional analysis of a single-site longitudinal population-based cohort.
PARTICIPANTS - The data for this study were drawn from the baseline examination of the Jackson Heart Study (JHS). The analytic cohort consisted of 3430 African American men and women (21-84 years of age) living in the tricounty area of the Jackson, Mississippi metropolitan areas with complete data to determine CKD status.
MAIN MEASUREMENTS - The primary dependent variable was CKD (defined as the presence of albuminuria or reduced estimated glomerular filtration rate <60 mL/min per 1.73 m(2)). Weight status, the primary predictor, was a 4-category measure based on body mass index.
RESULTS - Associations were explored through bivariable analyses and multivariable logistic regression analyses adjusting for CKD, weight status, diabetes, hypertension, and cardiovascular disease risk factors as well as demographic factors. The prevalence of CKD in the JHS was 20%. The proportion of overweight, class I, and class II obese individuals was 32.5%, 26.9%, and 26.2% respectively. In the pooled model, weight status was not found to be associated with CKD; however, subgroup analysis revealed that class II obesity was associated with CKD among men (odds ratio, 2.37; confidence interval, 1.34-4.19) but not among women (odds ratio, 1.32; confidence interval, 0.88-1.98). The relationship between CKD prevalence and diabetes and CKD prevalence and hypertension varied by sex and differed across weight categories.
CONCLUSIONS - Weight status has implications for CKD among the JHS participants, and this study underscores the need for additional research investigating the relationship between weight status, sex, and CKD among African Americans.
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20 MeSH Terms
The revolution in risk assessment and disease detection made possible with non-invasive imaging: implications for population science.
Carr JJ
(2012) Ethn Dis 22: S1-24-7
MeSH Terms: African Americans, Aorta, Body Mass Index, Cardiovascular Diseases, Cohort Studies, Comorbidity, Diabetic Angiopathies, Diagnostic Imaging, Heart Failure, Humans, Magnetic Resonance Imaging, Metabolic Syndrome, Mississippi, Risk Assessment
Show Abstract · Added February 15, 2014
The ability to quantify subclinical disease to assess cardiovascular disease is greatly enhanced by modern medical imaging techniques that incorporate concepts from biomedical engineering and computer science. These techniques' numerical results, known as quantitative phenotypes, can be used to help us better understand both health and disease states. In this report, we describe our efforts in using the latest imaging technologies to assess cardiovascular disease risk by quantifying subclinical disease of participants in the Jackson Heart Study. The CT and MRI exams of the Jackson Heart Study have collected detailed information from approximately 3,000 participants. Analyses of the images from these exams provide information on several measures including the amount of plaque in the coronary arteries and the ability of the heart to pump blood. These measures can then be added to the wealth of information on JHS participants to understand how these conditions, as well as how clinical events, such as heart attacks and heart failure, occur in African Americans.
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14 MeSH Terms
Fatty liver, abdominal adipose tissue and atherosclerotic calcification in African Americans: the Jackson Heart Study.
Liu J, Musani SK, Bidulescu A, Carr JJ, Wilson JG, Taylor HA, Fox CS
(2012) Atherosclerosis 224: 521-5
MeSH Terms: Abdominal Fat, Adiposity, Adult, African Americans, Aged, Aged, 80 and over, Aorta, Abdominal, Aortic Diseases, Body Mass Index, Coronary Artery Disease, Cross-Sectional Studies, Fatty Liver, Female, Humans, Logistic Models, Male, Middle Aged, Mississippi, Multivariate Analysis, Obesity, Abdominal, Odds Ratio, Risk Assessment, Risk Factors, Tomography, X-Ray Computed, Vascular Calcification, Young Adult
Show Abstract · Added February 15, 2014
OBJECTIVE - Both fatty liver and abdominal visceral fat (VAT) are associated with cardiometabolic risk factors. Whether fatty liver and VAT are jointly associated with coronary artery (CAC) or abdominal aortic (AAC) calcification is not clear.
METHODS - Jackson Heart Study (JHS) participants (n = 2884, mean age 60 years, 65% women) underwent non-contrast CT Exam for assessment of fatty liver, VAT, and CAC and AAC. Fatty liver was measured by liver attenuation (LA; low LA = high fatty liver). The Agatston score was used to quantify the amount of calcified artery plaque and the presence of calcified artery plaque was defined as Agatston score>0. Cross-sectional associations of LA and VAT with CAC and AAC were examined in logistic regression models.
RESULTS - LA (per 1-standard deviation [SD] decrement) was associated inversely with CAC in age-sex-adjusted (OR 0.84, 95%CI 0.7-0.9, p = 0.0001) and multivariable-adjusted models (OR 0.89, 95%CI 0.8-0.9, p = 0.01). The association persisted for LA with CAC when additionally adjusted for body mass index (BMI) (OR 0.89, 95%CI 0.8-0.9, p = 0.03) or VAT (OR 0.90, 95%CI 0.8-0.9, p = 0.04). Abdominal VAT (per 1-SD increment) was positively associated with CAC in age-sex-adjusted models (OR 1.27, 95%CI 1.2-1.4, p = 0.0001), but the association was diminished with multivariable adjustment (OR 1.10, 95%CI 0.9-1.2, p = 0.09) and with additional adjustment for LA (p = 0.24) or BMI (p = 0.33). For AAC, the associations with LA and VAT were only present in age-sex-adjusted models. Finally, we did not observe interactions between LA and VAT for CAC (p = 0.18) or AAC (p = 0.24).
CONCLUSION - Fatty liver is associated with coronary atherosclerotic calcification independent of abdominal VAT or BMI in African Americans. Further investigations to uncover the clinical implications of fatty liver on coronary atherosclerosis in obesity are warranted.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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26 MeSH Terms
Diabetes and psychological profile of younger rural African American women with type 2 diabetes.
Miller ST
(2011) J Health Care Poor Underserved 22: 1239-52
MeSH Terms: Adult, African Americans, Body Mass Index, Cross-Sectional Studies, Depression, Diabetes Mellitus, Type 2, Exercise, Female, Health Knowledge, Attitudes, Practice, Humans, Medication Adherence, Middle Aged, Mississippi, Rural Population, Self Care, Social Support, Socioeconomic Factors, Surveys and Questionnaires, Young Adult
Show Abstract · Added July 28, 2016
PURPOSE - To describe diabetes self-care behaviors, diabetes-related distress, depressive symptoms, and diabetes-related needs among rural African American women with type 2 diabetes ages 21-50.
METHODS - A cross-sectional survey, including questionnaires and a single, open-ended question, was used to assess constructs of interest.
FINDINGS - Taking medication was the most frequently reported (5.5 days/week) self-care activity and exercise the least (3.0 days/week). Nearly half (44%) reported worrying about diabetes complications. Approximately one-third (31%) felt guilty about inconsistent self-care or fearful about living with diabetes. Seventy percent had a depression score suggestive of significant depressive symptomatology. Most diabetes-related concerns were about diet (34%) (i.e., what to eat), exercise (30%), taking medications (10%), and finances (8%).
CONCLUSIONS - Future research should explore specific diabetes self-care barriers/enablers and interventions should provide women with diabetes education, barrier management, and psychological support. Innovative delivery strategies are needed to provide this support in resource-limited rural communities.
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19 MeSH Terms
Fatty liver, abdominal visceral fat, and cardiometabolic risk factors: the Jackson Heart Study.
Liu J, Fox CS, Hickson D, Bidulescu A, Carr JJ, Taylor HA
(2011) Arterioscler Thromb Vasc Biol 31: 2715-22
MeSH Terms: Adult, African Continental Ancestry Group, Aged, Aged, 80 and over, Cardiovascular Diseases, Cholesterol, HDL, Fatty Liver, Female, Humans, Intra-Abdominal Fat, Male, Metabolic Diseases, Metabolic Syndrome, Middle Aged, Mississippi, Regression Analysis, Retrospective Studies, Risk Factors, Triglycerides
Show Abstract · Added February 28, 2014
OBJECTIVE - The goal of this study was to examine whether fatty liver and abdominal visceral adipose tissue (VAT) are jointly associated with cardiometabolic abnormalities.
METHODS AND RESULTS - Black participants were from the Jackson Heart Study (n=2882, 65% women) who underwent computed tomography. Fatty liver was measured by liver attenuation in Hounsfield units (LA), and VAT was quantified volumetrically. Cross-sectional associations between LA, VAT, and cardiometabolic risk factors were assessed using linear and logistic regression, and their joint associations were further examined in 4 subgroups: high-LA/low-VAT (n=1704), low-LA/low-VAT (n=422), high-LA/high-VAT (n=436), and low-LA/high-VAT (n=320). Both LA and VAT were associated with most cardiometabolic traits (all P<0.0001), which persisted after additional adjustment for each other (LA, P<0.01-0.0001; VAT, P<0.0001). In bootstrap analyses, the regression coefficient of VAT was significantly greater than LA for triglycerides, high-density lipoprotein cholesterol, impaired glucose, and metabolic syndrome (P=0.009-0.0001). The interaction between LA and VAT was significant for high-density lipoprotein cholesterol (P=0.002), impaired glucose (P=0.003), and metabolic syndrome (P=0.04). Among 4 subgroups, participants with higher VAT and lower LA had higher prevalence of cardiometabolic traits than those with each condition alone.
CONCLUSION - Both fatty liver and VAT are independent correlates of cardiometabolic risk, but the associations are stronger for VAT than for fatty liver.
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19 MeSH Terms
A health insurance portability and accountability act-compliant ocular telehealth network for the remote diagnosis and management of diabetic retinopathy.
Li Y, Karnowski TP, Tobin KW, Giancardo L, Morris S, Sparrow SE, Garg S, Fox K, Chaum E
(2011) Telemed J E Health 17: 627-34
MeSH Terms: Computer Communication Networks, Computer Security, Diabetic Retinopathy, Diagnosis, Computer-Assisted, Disease Management, Health Insurance Portability and Accountability Act, Humans, Image Processing, Computer-Assisted, Mississippi, North Carolina, Ophthalmology, Telemedicine, Tennessee, United States
Show Abstract · Added June 11, 2018
In this article, we present the design and implementation of a regional ocular telehealth network for remote assessment and management of diabetic retinopathy (DR), including the design requirements, network topology, protocol design, system work flow, graphics user interfaces, and performance evaluation. The Telemedical Retinal Image Analysis and Diagnosis Network is a computer-aided, image analysis telehealth paradigm for the diagnosis of DR and other retinal diseases using fundus images acquired from primary care end users delivering care to underserved patient populations in the mid-South and southeastern United States.
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MeSH Terms
Pericardial adipose tissue, atherosclerosis, and cardiovascular disease risk factors: the Jackson heart study.
Liu J, Fox CS, Hickson D, Sarpong D, Ekunwe L, May WD, Hundley GW, Carr JJ, Taylor HA
(2010) Diabetes Care 33: 1635-9
MeSH Terms: African Americans, Aged, Aortic Diseases, Calcinosis, Cohort Studies, Coronary Artery Disease, Female, Humans, Intra-Abdominal Fat, Logistic Models, Male, Metabolic Syndrome, Middle Aged, Mississippi, Multivariate Analysis, Pericardium, Risk Factors, Tomography, X-Ray Computed, Waist Circumference
Show Abstract · Added February 15, 2014
OBJECTIVE - Pericardial adipose tissue (PAT), a regional fat depot that surrounds the heart, is associated with an unfavorable cardiometabolic risk factor profile. The associations among PAT, cardiometabolic risk factors, and coronary artery calcification (CAC) and abdominal aortic artery calcification (AAC) in African American populations have not been explored.
RESEARCH DESIGN AND METHODS - A total of 1,414 African Americans (35% men; mean +/- SD age 58 +/- 11 years) drawn from the Jackson Heart Study (JHS) underwent multidetector computed tomography assessment of abdominal visceral adipose tissue (VAT) and PAT between 2007 and 2009. Cardiometabolic risk factors, CAC, and AAC were examined in relation to increments of PAT and VAT.
RESULTS - PAT was significantly correlated with BMI, waist circumference, and VAT (r = 0.35, 0.46, and 0.69; all P < 0.0001). PAT (per 1-SD increase) was associated with elevated levels of systolic blood pressure (P < 0.04), fasting glucose, triglycerides, and C-reactive protein and lower levels of HDL (all P values<0.0001). PAT was also associated with metabolic syndrome (odds ratio [OR] 1.89; P < 0.0001), hypertension (1.48; P < 0.0006), and diabetes (1.40; P < 0.04); all associations were diminished after further adjustment for VAT (most P > 0.05). However, the association of PAT with CAC but not with AAC remained significant (OR 1.34 [95% CI 1.10-1.64]; P < 0.004) after multivariable and VAT adjustment.
CONCLUSIONS - PAT is significantly correlated with most cardiometabolic risk factors and CAC in the JHS cohort. The results suggest that PAT is an important VAT depot that may exert a local effect on the coronary vasculature.
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19 MeSH Terms
Migration patterns following HIV diagnosis among adults residing in the nonurban Deep South.
Agee BS, Funkhouser E, Roseman JM, Fawal H, Holmberg SD, Vermund SH
(2006) AIDS Care 18 Suppl 1: S51-8
MeSH Terms: Adolescent, Alabama, Female, HIV Infections, Humans, Male, Mississippi, Population Dynamics, Risk Factors, Socioeconomic Factors, Substance Abuse, Intravenous
Show Abstract · Added March 5, 2014
Health care needs of those infected with the human immunodeficiency virus (HIV) and subsequent transmission dynamics are altered by migration after infection. We interviewed 760 HIV-infected persons attending HIV-specialty clinics living in non-urban Alabama and Mississippi to ascertain the likely geographic origins of their infections, determine their post-HIV diagnosis mobility, and identify predictors of this mobility. Most subjects (81%) were living in these two states when diagnosed and have not moved since learning of their HIV status (70%). Of those who moved their primary residence post-HIV diagnosis (25% of the entire study population), the majority in-migrated to Alabama or Mississippi from elsewhere. Persons who had moved post-HIV diagnosis were more likely to be male, an injection drug user, an urban resident at HIV diagnosis, have an AIDS-defining condition, and have moved prior to HIV diagnosis. We conclude that most HIV transmission in non-urban Alabama and Mississippi is acquired locally. These results underline the need to expand HIV prevention programs in the Deep South.
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11 MeSH Terms