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Results: 1 to 7 of 7

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The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10.
Paulson CN, John K, Baxley RM, Kurniawan F, Orellana K, Francis R, Sobeck A, Eichman BF, Chazin WJ, Aihara H, Georg GI, Hawkinson JE, Bielinsky AK
(2019) Open Biol 9: 190117
MeSH Terms: Animals, Cell Survival, DNA Replication, DNA-Binding Proteins, Drug Discovery, Enzyme Inhibitors, Gene Expression, High-Throughput Nucleotide Sequencing, Humans, Kinetics, Minichromosome Maintenance Proteins, Molecular Structure, Protein Binding, Suramin, Xenopus
Added August 26, 2019
0 Communities
2 Members
0 Resources
15 MeSH Terms
Mcm10 self-association is mediated by an N-terminal coiled-coil domain.
Du W, Josephrajan A, Adhikary S, Bowles T, Bielinsky AK, Eichman BF
(2013) PLoS One 8: e70518
MeSH Terms: Amino Acid Sequence, Animals, DNA Replication, Minichromosome Maintenance Proteins, Models, Molecular, Mutation, Protein Multimerization, Protein Structure, Tertiary, Sequence Alignment, Xenopus laevis
Added March 7, 2014
1 Communities
1 Members
0 Resources
10 MeSH Terms
Structural biology of replication initiation factor Mcm10.
Du W, Stauffer ME, Eichman BF
(2012) Subcell Biochem 62: 197-216
MeSH Terms: Animals, DNA, DNA, Single-Stranded, DNA-Directed DNA Polymerase, Humans, Minichromosome Maintenance Proteins, S Phase
Added March 11, 2014
1 Communities
1 Members
0 Resources
7 MeSH Terms
Solution NMR structure of the C-terminal DNA binding domain of Mcm10 reveals a conserved MCM motif.
Robertson PD, Chagot B, Chazin WJ, Eichman BF
(2010) J Biol Chem 285: 22942-9
MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Animals, Conserved Sequence, DNA, DNA-Binding Proteins, Humans, Mice, Minichromosome Maintenance Proteins, Models, Molecular, Molecular Sequence Data, Nuclear Magnetic Resonance, Biomolecular, Protein Structure, Tertiary, Xenopus laevis, Zinc
Added March 7, 2014
1 Communities
2 Members
0 Resources
15 MeSH Terms
Physical interactions between Mcm10, DNA, and DNA polymerase alpha.
Warren EM, Huang H, Fanning E, Chazin WJ, Eichman BF
(2009) J Biol Chem 284: 24662-72
MeSH Terms: Amino Acid Motifs, Binding Sites, Cell Cycle Proteins, Crystallography, X-Ray, DNA Polymerase I, DNA, Single-Stranded, Humans, Minichromosome Maintenance Proteins, Nuclear Magnetic Resonance, Biomolecular, Protein Binding
Added March 11, 2014
1 Communities
2 Members
0 Resources
10 MeSH Terms
Structural basis for DNA binding by replication initiator Mcm10.
Warren EM, Vaithiyalingam S, Haworth J, Greer B, Bielinsky AK, Chazin WJ, Eichman BF
(2008) Structure 16: 1892-901
MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Animals, Binding Sites, Biophysical Phenomena, DNA, DNA Mutational Analysis, DNA Polymerase I, DNA Replication, DNA-Binding Proteins, Minichromosome Maintenance Proteins, Models, Biological, Models, Molecular, Molecular Sequence Data, Mutation, Nuclear Magnetic Resonance, Biomolecular, Proliferating Cell Nuclear Antigen, Protein Binding, Protein Structure, Tertiary, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Zinc Fingers
Added March 11, 2014
1 Communities
2 Members
0 Resources
23 MeSH Terms
Domain architecture and biochemical characterization of vertebrate Mcm10.
Robertson PD, Warren EM, Zhang H, Friedman DB, Lary JW, Cole JL, Tutter AV, Walter JC, Fanning E, Eichman BF
(2008) J Biol Chem 283: 3338-3348
MeSH Terms: Amino Acid Sequence, Animals, Anisotropy, Cell Cycle Proteins, DNA Replication, DNA-Binding Proteins, DNA-Directed DNA Polymerase, Edetic Acid, Humans, Minichromosome Maintenance Proteins, Molecular Sequence Data, Protein Binding, Protein Conformation, Protein Structure, Tertiary, Spectrometry, Fluorescence, Xenopus laevis
Added March 11, 2014
1 Communities
1 Members
0 Resources
16 MeSH Terms