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Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots.
Trogden KP, Lee J, Bracey KM, Ho KH, McKinney H, Zhu X, Arpag G, Folland TG, Osipovich AB, Magnuson MA, Zanic M, Gu G, Holmes WR, Kaverina I
(2021) Elife 10:
MeSH Terms: Animals, Female, Insulin, Insulin Secretion, Insulin-Secreting Cells, Male, Mice, Microtubules, Spatio-Temporal Analysis
Added December 7, 2021
1 Communities
0 Members
0 Resources
9 MeSH Terms
A cytoskeletal function for PBRM1 reading methylated microtubules.
Karki M, Jangid RK, Anish R, Seervai RNH, Bertocchio JP, Hotta T, Msaouel P, Jung SY, Grimm SL, Coarfa C, Weissman BE, Ohi R, Verhey KJ, Hodges HC, Burggren W, Dere R, Park IY, Prasad BVV, Rathmell WK, Walker CL, Tripathi DN
(2021) Sci Adv 7:
MeSH Terms: Chromatin, Chromatin Assembly and Disassembly, Cytoskeleton, Microtubules, Reading
Added April 27, 2021
0 Communities
1 Members
0 Resources
5 MeSH Terms
Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion via Tau Phosphorylation.
Ho KH, Yang X, Osipovich AB, Cabrera O, Hayashi ML, Magnuson MA, Gu G, Kaverina I
(2020) Diabetes 69: 1936-1947
MeSH Terms: Animals, Cyclic AMP-Dependent Protein Kinases, Cyclin-Dependent Kinase 5, Glucose, Glycogen Synthase Kinase 3, Insulin Secretion, Insulin-Secreting Cells, Mice, Microtubules, Phosphorylation, Protein Kinase C, tau Proteins
Added July 2, 2020
2 Communities
4 Members
0 Resources
12 MeSH Terms
Microtubules Regulate Localization and Availability of Insulin Granules in Pancreatic Beta Cells.
Bracey KM, Ho KH, Yampolsky D, Gu G, Kaverina I, Holmes WR
(2020) Biophys J 118: 193-206
MeSH Terms: Animals, Insulin, Insulin-Secreting Cells, Mice, Microtubules, Models, Molecular
Added December 4, 2020
1 Communities
1 Members
0 Resources
6 MeSH Terms
Regulation of Glucose-Dependent Golgi-Derived Microtubules by cAMP/EPAC2 Promotes Secretory Vesicle Biogenesis in Pancreatic β Cells.
Trogden KP, Zhu X, Lee JS, Wright CVE, Gu G, Kaverina I
(2019) Curr Biol 29: 2339-2350.e5
MeSH Terms: Animals, Cyclic AMP, Glucose, Golgi Apparatus, Guanine Nucleotide Exchange Factors, Insulin-Secreting Cells, Male, Mice, Mice, Inbred ICR, Microtubules, Organelle Biogenesis, Secretory Vesicles
Added August 6, 2019
1 Communities
2 Members
0 Resources
12 MeSH Terms
p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton.
Fuertes-Alvarez S, Maeso-Alonso L, Villoch-Fernandez J, Wildung M, Martin-Lopez M, Marshall C, Villena-Cortes AJ, Diez-Prieto I, Pietenpol JA, Tissir F, Lizé M, Marques MM, Marin MC
(2018) Cell Death Dis 9: 1183
MeSH Terms: Animals, Carrier Proteins, Cell Polarity, Cilia, Cytoskeleton, Ependyma, Female, Frizzled Receptors, Gene Expression Regulation, Gene Ontology, HCT116 Cells, Humans, Male, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Microtubules, Molecular Sequence Annotation, Nerve Tissue Proteins, Nonmuscle Myosin Type IIA, Pluripotent Stem Cells, Signal Transduction, Tumor Protein p73
Added March 27, 2019
0 Communities
1 Members
0 Resources
24 MeSH Terms
The balance between adhesion and contraction during cell division.
Taneja N, Rathbun L, Hehnly H, Burnette DT
(2019) Curr Opin Cell Biol 56: 45-52
MeSH Terms: Animals, Cell Adhesion, Centrosome, Humans, Microtubules, Mitosis, Signal Transduction, Spindle Apparatus
Added March 27, 2019
0 Communities
1 Members
0 Resources
8 MeSH Terms
Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters.
Norris SR, Jung S, Singh P, Strothman CE, Erwin AL, Ohi MD, Zanic M, Ohi R
(2018) Nat Commun 9: 2659
MeSH Terms: Animals, Cell Tracking, Green Fluorescent Proteins, HeLa Cells, Humans, Kinesins, Microscopy, Fluorescence, Microtubules, Molecular Motor Proteins, Protein Binding, Time-Lapse Imaging, Tubulin
Added March 3, 2020
0 Communities
1 Members
0 Resources
12 MeSH Terms
Loss of CENP-F Results in Dilated Cardiomyopathy with Severe Disruption of Cardiac Myocyte Architecture.
Manalo A, Schroer AK, Fenix AM, Shancer Z, Coogan J, Brolsma T, Burnette DT, Merryman WD, Bader DM
(2018) Sci Rep 8: 7546
MeSH Terms: Animals, Cardiomyopathy, Dilated, Chromosomal Proteins, Non-Histone, Disease Models, Animal, Genetic Association Studies, Genetic Predisposition to Disease, Heart Failure, Humans, Intercellular Junctions, Loss of Function Mutation, Mice, Microfilament Proteins, Microtubules, Myocytes, Cardiac, Polymorphism, Single Nucleotide, Stroke Volume
Added March 27, 2019
0 Communities
1 Members
0 Resources
16 MeSH Terms
Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma.
Chiang YC, Park IY, Terzo EA, Tripathi DN, Mason FM, Fahey CC, Karki M, Shuster CB, Sohn BH, Chowdhury P, Powell RT, Ohi R, Tsai YS, de Cubas AA, Khan A, Davis IJ, Strahl BD, Parker JS, Dere R, Walker CL, Rathmell WK
(2018) Cancer Res 78: 3135-3146
MeSH Terms: Animals, Carcinogenesis, Carcinoma, Renal Cell, Cell Line, Tumor, Chromosomes, Human, Pair 3, Fibroblasts, Gene Knockdown Techniques, Genomic Instability, Haploinsufficiency, Histone-Lysine N-Methyltransferase, Histones, Humans, Kidney Neoplasms, Kidney Tubules, Proximal, Lysine, Methylation, Mice, Micronuclei, Chromosome-Defective, Microtubules
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms