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MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors.
Brown RE, Jacobse J, Anant SA, Blunt KM, Chen B, Vega PN, Jones CT, Pilat JM, Revetta F, Gorby AH, Stengel KR, Choksi YA, Palin K, Piazuelo MB, Washington MK, Lau KS, Goettel JA, Hiebert SW, Short SP, Williams CS
(2022) JCI Insight 7:
MeSH Terms: Animals, Carcinogenesis, Cell Transformation, Neoplastic, Colitis, Dextran Sulfate, Humans, Inflammatory Bowel Diseases, Mice, Mice, Inbred C57BL, Mice, Knockout, Transcription Factors
Added June 13, 2022
1 Communities
0 Members
0 Resources
MeSH Terms
EPO synthesis induced by HIF-PHD inhibition is dependent on myofibroblast transdifferentiation and colocalizes with non-injured nephron segments in murine kidney fibrosis.
Kobayashi H, Davidoff O, Pujari-Palmer S, Drevin M, Haase VH
(2022) Acta Physiol (Oxf) 235: e13826
MeSH Terms: Animals, Cell Transdifferentiation, Erythropoietin, Fibrosis, Hypoxia-Inducible Factor-Proline Dioxygenases, Kidney, Mice, Mice, Knockout, Myofibroblasts, Nephrons, Prolyl Hydroxylases, Renal Insufficiency, Chronic
Added May 3, 2022
0 Communities
1 Members
0 Resources
12 MeSH Terms
Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic β-cells.
Rahim M, Nakhe AY, Banerjee DR, Overway EM, Bosma KJ, Rosch JC, Oeser JK, Wang B, Lippmann ES, Jacobson DA, O'Brien RM, Young JD
(2022) J Biol Chem 298: 101729
MeSH Terms: Animals, Blood Glucose, Diabetes Mellitus, Type 2, Genome-Wide Association Study, Glucose, Glucose-6-Phosphatase, Insulin, Insulin Secretion, Insulin-Secreting Cells, Mice, Mice, Knockout, Oxidation-Reduction
Added June 27, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Cyclooxygenase-2 deficiency attenuates lipopolysaccharide-induced inflammation, apoptosis, and acute lung injury in adult mice.
Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J
(2022) Am J Physiol Regul Integr Comp Physiol 322: R126-R135
MeSH Terms: Acute Lung Injury, Animals, Apoptosis, Caspase 3, Caspase 9, Chemokine CCL2, Cyclooxygenase 2, Disease Models, Animal, Female, Interleukin-10, Lipopolysaccharides, Lung, Male, Mice, Knockout, Pneumonia, Signal Transduction, Tumor Necrosis Factor-alpha
Added February 1, 2022
0 Communities
1 Members
0 Resources
17 MeSH Terms
DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3.
Borza CM, Bolas G, Bock F, Zhang X, Akabogu FC, Zhang MZ, de Caestecker M, Yang M, Yang H, Lee E, Gewin L, Fogo AB, McDonald WH, Zent R, Pozzi A
(2022) JCI Insight 7:
MeSH Terms: Acute Kidney Injury, Animals, Cell Line, Cells, Cultured, Discoidin Domain Receptor 1, Female, Fibrosis, Gene Expression Regulation, Inflammation, Kidney Tubules, Proximal, Male, Mice, Mice, Knockout, Phosphorylation, Proto-Oncogene Proteins c-bcr, RNA, STAT3 Transcription Factor, Signal Transduction
Added December 27, 2021
0 Communities
1 Members
0 Resources
18 MeSH Terms
CCL11 exacerbates colitis and inflammation-associated colon tumorigenesis.
Polosukhina D, Singh K, Asim M, Barry DP, Allaman MM, Hardbower DM, Piazuelo MB, Washington MK, Gobert AP, Wilson KT, Coburn LA
(2021) Oncogene 40: 6540-6546
MeSH Terms: Animals, Azoxymethane, Carcinogenesis, Carcinogens, Chemokine CCL11, Colitis, Colitis-Associated Neoplasms, Epithelial Cells, Mice, Mice, Knockout
Added October 10, 2021
0 Communities
1 Members
0 Resources
10 MeSH Terms
TRPM7 is a crucial regulator of pancreatic endocrine development and high-fat-diet-induced β-cell proliferation.
Altman MK, Schaub CM, Dadi PK, Dickerson MT, Zaborska KE, Nakhe AY, Graff SM, Galletta TJ, Amarnath G, Thorson AS, Gu G, Jacobson DA
(2021) Development 148:
MeSH Terms: Animals, Cell Proliferation, Cells, Cultured, Diet, High-Fat, Gene Knockout Techniques, Glucose Intolerance, Homeostasis, Insulin, Insulin Secretion, Insulin-Secreting Cells, Magnesium, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Pancreas, TRPM Cation Channels
Added August 13, 2021
1 Communities
1 Members
0 Resources
17 MeSH Terms
Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance.
Kaji I, Roland JT, Rathan-Kumar S, Engevik AC, Burman A, Goldstein AE, Watanabe M, Goldenring JR
(2021) JCI Insight 6:
MeSH Terms: Animals, Cell Differentiation, Cells, Cultured, Dibenzazepines, Disease Models, Animal, Enterocytes, Humans, Intestinal Mucosa, Jejunum, Lysophospholipids, Malabsorption Syndromes, Mice, Mice, Knockout, Microvilli, Mucolipidoses, Myosin Type V, Organoids, Primary Cell Culture, Receptors, Notch, Stem Cells, Wnt Signaling Pathway
Added August 16, 2021
1 Communities
0 Members
0 Resources
21 MeSH Terms
Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4 T cells.
Hoek KL, Greer MJ, McClanahan KG, Nazmi A, Piazuelo MB, Singh K, Wilson KT, Olivares-Villagómez D
(2021) Mucosal Immunol 14: 1088-1099
MeSH Terms: Animals, Biomarkers, CD4-Positive T-Lymphocytes, Cell Differentiation, Cell Transplantation, Cytokines, Disease Susceptibility, Female, Gene Expression Profiling, Gene Expression Regulation, Granzymes, Immune Reconstitution, Immunophenotyping, Interleukin-17, Intraepithelial Lymphocytes, Lymphocyte Activation, Male, Mice, Mice, Knockout, Mice, Transgenic, T-Lymphocyte Subsets, T-Lymphocytes, Helper-Inducer
Added July 1, 2021
0 Communities
1 Members
0 Resources
22 MeSH Terms
KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models.
West JD, Austin ED, Rizzi EM, Yan L, Tanjore H, Crabtree AL, Moore CS, Muthian G, Carrier EJ, Jacobson DA, Hamid R, Kendall PL, Majka S, Rathinasabapathy A
(2021) Int J Mol Sci 22:
MeSH Terms: Animals, Biomarkers, Case-Control Studies, Cytokines, Disease Models, Animal, Disease Susceptibility, Gene Expression Profiling, Genetic Predisposition to Disease, Humans, Hypoxia, Immunomodulation, Lymphocytes, Mice, Mice, Knockout, Models, Biological, Monocytes, Mutation, Nerve Tissue Proteins, Potassium Channels, Tandem Pore Domain, Pulmonary Arterial Hypertension, Transcriptome
Added June 14, 2021
0 Communities
1 Members
0 Resources
21 MeSH Terms