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HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice.
Tyagi RK, Jacobse J, Li J, Allaman MM, Otipoby KL, Sampson ER, Wilson KT, Goettel JA
(2021) Front Immunol 12: 630204
MeSH Terms: Animals, HLA Antigens, Humans, Inflammatory Bowel Diseases, Interleukin-2, Mice, Mice, Inbred NOD, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory, Trinitrobenzenesulfonic Acid
Added March 17, 2021
0 Communities
1 Members
0 Resources
10 MeSH Terms
T-B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein.
Bonami RH, Nyhoff LE, McNitt DH, Hulbert C, Felton JL, Kendall PL, Thomas JW
(2020) J Immunol 205: 3263-3276
MeSH Terms: Animals, Autoantibodies, B-Lymphocytes, Cell Communication, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 1, Mice, Mice, Inbred NOD, Mice, Transgenic, Signaling Lymphocytic Activation Molecule Associated Protein, Th1 Cells
Added December 1, 2020
1 Communities
0 Members
0 Resources
11 MeSH Terms
Dapagliflozin Does Not Directly Affect Human α or β Cells.
Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC
(2020) Endocrinology 161:
MeSH Terms: Adolescent, Adult, Animals, Benzhydryl Compounds, Cells, Cultured, Female, Glucagon, Glucagon-Secreting Cells, Glucosides, Heterografts, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Islets of Langerhans, Male, Mice, Mice, Inbred NOD, Mice, Transgenic, Middle Aged, Signal Transduction, Species Specificity, Young Adult
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction.
Lim SP, Costantini B, Mian SA, Perez Abellan P, Gandhi S, Martinez Llordella M, Lozano JJ, Antunes Dos Reis R, Povoleri GAM, Mourikis TP, Abarrategi A, Ariza-McNaughton L, Heck S, Irish JM, Lombardi G, Marsh JCW, Bonnet D, Kordasti S, Mufti GJ
(2020) Blood 136: 885-897
MeSH Terms: Anemia, Aplastic, Animals, Apoptosis, Cells, Cultured, Fas Ligand Protein, Female, Humans, Immune System Diseases, Immune Tolerance, Interleukin-2, Male, Mice, Mice, Inbred NOD, Mice, SCID, Mice, Transgenic, T-Lymphocytes, Regulatory
Added June 8, 2020
1 Communities
1 Members
0 Resources
16 MeSH Terms
Regulation of Diabetogenic Immunity by IL-15-Activated Regulatory CD8 T Cells in Type 1 Diabetes.
Stocks BT, Wilson CS, Marshall AF, Hoopes EM, Moore DJ
(2019) J Immunol 203: 158-166
MeSH Terms: Adoptive Transfer, Animals, B-Lymphocytes, CD8 Antigens, Cells, Cultured, Diabetes Mellitus, Type 1, Disease Models, Animal, Humans, Immunotherapy, Adoptive, Interleukin-15, Macrophages, Mice, Mice, Inbred NOD, NK Cell Lectin-Like Receptor Subfamily A, T-Lymphocytes, Regulatory
Added May 28, 2019
0 Communities
1 Members
0 Resources
15 MeSH Terms
Impaired insulin signaling in the B10.D2--/oSnJ mouse model of complement factor 5 deficiency.
Peterson KR, Gutierrez DA, Kikuchi T, Anderson-Baucum EK, Winn NC, Shuey MM, Bolus WR, McGuinness OP, Hasty AH
(2019) Am J Physiol Endocrinol Metab 317: E200-E211
MeSH Terms: Adenoviridae, Animals, Complement C5, Disease Models, Animal, Energy Metabolism, Glucose Intolerance, Hereditary Complement Deficiency Diseases, Insulin Resistance, Mice, Mice, Inbred AKR, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Inbred DBA, Mice, Inbred NOD, Mice, Transgenic, Signal Transduction, Transduction, Genetic
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
B lymphocytes protect islet β cells in diabetes prone NOD mice treated with imatinib.
Wilson CS, Spaeth JM, Karp J, Stocks BT, Hoopes EM, Stein RW, Moore DJ
(2019) JCI Insight 5:
MeSH Terms: Animals, Autoimmunity, B-Lymphocytes, Cell Proliferation, Diabetes Mellitus, Type 1, Disease Models, Animal, Homeodomain Proteins, Hyperglycemia, Imatinib Mesylate, Insulin, Insulin-Secreting Cells, Islets of Langerhans, Maf Transcription Factors, Large, Mice, Mice, Inbred C57BL, Mice, Inbred NOD, Mice, Knockout
Added April 10, 2019
0 Communities
1 Members
0 Resources
17 MeSH Terms
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.
Lee T, Christov PP, Shaw S, Tarr JC, Zhao B, Veerasamy N, Jeon KO, Mills JJ, Bian Z, Sensintaffar JL, Arnold AL, Fogarty SA, Perry E, Ramsey HE, Cook RS, Hollingshead M, Davis Millin M, Lee KM, Koss B, Budhraja A, Opferman JT, Kim K, Arteaga CL, Moore WJ, Olejniczak ET, Savona MR, Fesik SW
(2019) J Med Chem 62: 3971-3988
MeSH Terms: Animals, Antineoplastic Agents, Azepines, Binding Sites, Cell Line, Tumor, Cell Survival, Crystallography, X-Ray, Drug Evaluation, Preclinical, Female, Humans, Mice, Mice, Inbred NOD, Mice, SCID, Molecular Dynamics Simulation, Myeloid Cell Leukemia Sequence 1 Protein, Neoplasms, Protein Structure, Tertiary, Small Molecule Libraries, Structure-Activity Relationship, Xenograft Model Antitumor Assays
Added April 15, 2019
0 Communities
1 Members
0 Resources
20 MeSH Terms
Is a Tumor Suppressor Gene in Colorectal Cancer.
Chen MS, Lo YH, Chen X, Williams CS, Donnelly JM, Criss ZK, Patel S, Butkus JM, Dubrulle J, Finegold MJ, Shroyer NF
(2019) Mol Cancer Res 17: 697-708
MeSH Terms: Animals, Cell Line, Tumor, Colorectal Neoplasms, DNA-Binding Proteins, Genes, Tumor Suppressor, HCT116 Cells, HEK293 Cells, Heterografts, Humans, Male, Mice, Mice, Inbred NOD, Transcription Factors
Added April 15, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis.
Saunders DC, Brissova M, Phillips N, Shrestha S, Walker JT, Aramandla R, Poffenberger G, Flaherty DK, Weller KP, Pelletier J, Cooper T, Goff MT, Virostko J, Shostak A, Dean ED, Greiner DL, Shultz LD, Prasad N, Levy SE, Carnahan RH, Dai C, Sévigny J, Powers AC
(2019) Cell Metab 29: 745-754.e4
MeSH Terms: Adenosine Triphosphatases, Adult, Animals, Biomarkers, Cells, Cultured, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Insulin-Secreting Cells, Islets of Langerhans, Male, Membrane Proteins, Mice, Mice, Inbred NOD, Pancreas, Young Adult
Added February 4, 2019
0 Communities
3 Members
0 Resources
16 MeSH Terms