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Long-term outcomes in mouse models of ischemia-reperfusion-induced acute kidney injury.
Scarfe L, Menshikh A, Newton E, Zhu Y, Delgado R, Finney C, de Caestecker MP
(2019) Am J Physiol Renal Physiol 317: F1068-F1080
MeSH Terms: Acute Kidney Injury, Animals, Diabetes Mellitus, Experimental, Diabetic Nephropathies, Disease Models, Animal, Female, Fibrosis, Kidney Function Tests, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Nephrectomy, Reperfusion Injury, Sex Characteristics, Species Specificity
Added May 10, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Impaired insulin signaling in the B10.D2--/oSnJ mouse model of complement factor 5 deficiency.
Peterson KR, Gutierrez DA, Kikuchi T, Anderson-Baucum EK, Winn NC, Shuey MM, Bolus WR, McGuinness OP, Hasty AH
(2019) Am J Physiol Endocrinol Metab 317: E200-E211
MeSH Terms: Adenoviridae, Animals, Complement C5, Disease Models, Animal, Energy Metabolism, Glucose Intolerance, Hereditary Complement Deficiency Diseases, Insulin Resistance, Mice, Mice, Inbred AKR, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Inbred DBA, Mice, Inbred NOD, Mice, Transgenic, Signal Transduction, Transduction, Genetic
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, Winder DG, Alford S, Hamm HE
(2019) Sci Signal 12:
MeSH Terms: Animals, Calcium, Exocytosis, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Knockout, Neural Inhibition, Phenotype, Protein Binding, Receptors, G-Protein-Coupled, Synaptic Transmission, Synaptosomal-Associated Protein 25
Added February 22, 2019
1 Communities
3 Members
0 Resources
15 MeSH Terms
The proto-oncogene function of Mdm2 in bone.
Olivos DJ, Perrien DS, Hooker A, Cheng YH, Fuchs RK, Hong JM, Bruzzaniti A, Chun K, Eischen CM, Kacena MA, Mayo LD
(2018) J Cell Biochem 119: 8830-8840
MeSH Terms: Analysis of Variance, Animals, Bone Density, Bone Remodeling, Calcification, Physiologic, Cancellous Bone, Cell Line, Tumor, Female, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Inbred DBA, Osteoblasts, Osteoclasts, Osteogenesis, Osteosarcoma, Proto-Oncogene Mas, Proto-Oncogene Proteins c-mdm2, Proto-Oncogenes
Added April 1, 2019
0 Communities
2 Members
0 Resources
20 MeSH Terms
The Molecular Basis for the Lack of Inflammatory Responses in Mouse Embryonic Stem Cells and Their Differentiated Cells.
D'Angelo W, Gurung C, Acharya D, Chen B, Ortolano N, Gama V, Bai F, Guo YL
(2017) J Immunol 198: 2147-2155
MeSH Terms: Animals, Cell Differentiation, Chikungunya Fever, Chikungunya virus, Embryonic Stem Cells, Immunity, Inflammation, Interferons, Lipopolysaccharides, Mice, Mice, Inbred DBA, NF-kappa B, RAW 264.7 Cells, Tumor Necrosis Factor-alpha, Virus Diseases
Added July 10, 2017
0 Communities
1 Members
0 Resources
15 MeSH Terms
The impact of SGLT2 inhibitors, compared with insulin, on diabetic bone disease in a mouse model of type 1 diabetes.
Thrailkill KM, Nyman JS, Bunn RC, Uppuganti S, Thompson KL, Lumpkin CK, Kalaitzoglou E, Fowlkes JL
(2017) Bone 94: 141-151
MeSH Terms: Animals, Biomarkers, Blood Glucose, Bone Diseases, Metabolic, Bone Resorption, Bone and Bones, Canagliflozin, Diabetes Mellitus, Type 1, Disease Models, Animal, Fibroblast Growth Factor-23, Insulin, Linear Models, Male, Mice, Inbred DBA, Phenotype, Sodium-Glucose Transporter 2, Sodium-Glucose Transporter 2 Inhibitors
Added January 9, 2017
2 Communities
1 Members
0 Resources
17 MeSH Terms
Erythropoietin either Prevents or Exacerbates Retinal Damage from Eye Trauma Depending on Treatment Timing.
Bricker-Anthony C, D'Surney L, Lunn B, Hines-Beard J, Jo M, Bernardo-Colon A, Rex TS
(2017) Optom Vis Sci 94: 20-32
MeSH Terms: Animals, Blast Injuries, Cell Survival, Dependovirus, Disease Models, Animal, Erythropoietin, Eye Injuries, Ferritins, Genetic Therapy, Genetic Vectors, Green Fluorescent Proteins, In Situ Nick-End Labeling, Injections, Intramuscular, Injections, Intraperitoneal, Mice, Mice, Inbred BALB C, Mice, Inbred DBA, NADPH Oxidases, Oxidative Stress, Polymerase Chain Reaction, Retina, Retinal Diseases, Time Factors, Vision Disorders, Wounds, Nonpenetrating
Added April 2, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Virus-mediated EpoR76E gene therapy preserves vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress.
Hines-Beard J, Bond WS, Backstrom JR, Rex TS
(2016) J Neuroinflammation 13: 39
MeSH Terms: Animals, Calcium-Binding Proteins, Cholera Toxin, Cytokines, Dependovirus, Disease Models, Animal, Erythropoietin, Evoked Potentials, Visual, Fluorescein Angiography, Gene Expression Regulation, Genetic Therapy, Glaucoma, Ki-67 Antigen, Mice, Mice, Inbred DBA, Microfilament Proteins, Microglia, Oxidative Stress, Photic Stimulation, Retina, Transduction, Genetic
Added April 2, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma.
Bosco A, Breen KT, Anderson SR, Steele MR, Calkins DJ, Vetter ML
(2016) Exp Eye Res 150: 34-43
MeSH Terms: Animals, Astrocytes, Axons, Chronic Disease, Disease Models, Animal, Female, Glaucoma, Gliosis, Male, Mice, Mice, Inbred DBA, Microscopy, Confocal, Neuroglia, Optic Nerve, Optic Nerve Diseases, Photomicrography, Retinal Ganglion Cells
Added February 8, 2016
0 Communities
1 Members
0 Resources
17 MeSH Terms
Joint mouse-human phenome-wide association to test gene function and disease risk.
Wang X, Pandey AK, Mulligan MK, Williams EG, Mozhui K, Li Z, Jovaisaite V, Quarles LD, Xiao Z, Huang J, Capra JA, Chen Z, Taylor WL, Bastarache L, Niu X, Pollard KS, Ciobanu DC, Reznik AO, Tishkov AV, Zhulin IB, Peng J, Nelson SF, Denny JC, Auwerx J, Lu L, Williams RW
(2016) Nat Commun 7: 10464
MeSH Terms: Animals, Bone Density, Caenorhabditis elegans, Fumarate Hydratase, Gene Expression Regulation, Gene Library, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genomics, Humans, Mice, Mice, Inbred DBA, Quantitative Trait Loci
Added April 29, 2016
1 Communities
2 Members
0 Resources
14 MeSH Terms