Mitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse models.
Chattopadhyay M, Chowdhury AR, Feng T, Assenmacher CA, Radaelli E, Guengerich FP, Avadhani NG
(2019) J Biol Chem 294
: 10336-10348MeSH Terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Cytochrome P-450 CYP2D6, Disease Models, Animal, Humans, Male, Methylamines, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitochondria, Neuroblastoma, Neurons, Neurotoxins, Parkinson Disease, Tumor Cells, CulturedAdded March 3, 2020
Microbiota-Dependent Metabolite Trimethylamine N-Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA).
Meyer KA, Benton TZ, Bennett BJ, Jacobs DR, Lloyd-Jones DM, Gross MD, Carr JJ, Gordon-Larsen P, Zeisel SH
(2016) J Am Heart Assoc 5
: MeSH Terms: Adult, African Americans, Atherosclerosis, Carotid Intima-Media Thickness, Coronary Artery Disease, Disease Progression, Female, Gastrointestinal Microbiome, Humans, Incidence, Longitudinal Studies, Male, Methylamines, Middle Aged, Prospective Studies, Tomography, X-Ray Computed, United States, Vascular Calcification, WhitesAdded September 11, 2017
19 MeSH Terms
Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients.
Robinson-Cohen C, Newitt R, Shen DD, Rettie AE, Kestenbaum BR, Himmelfarb J, Yeung CK
(2016) PLoS One 11
: e0161074MeSH Terms: Biomarkers, Disease Progression, Female, Humans, Male, Methylamines, Middle Aged, Oxygenases, Polymorphism, Single Nucleotide, Prognosis, Prospective Studies, Renal Insufficiency, Chronic, Survival RateAdded September 19, 2017
13 MeSH Terms
Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions.
Zhang LS, Davies SS
(2016) Genome Med 8
: 46MeSH Terms: Animals, Diet, Disease Susceptibility, Energy Metabolism, Fatty Acids, Volatile, Gastrointestinal Microbiome, Gastrointestinal Tract, Homeostasis, Humans, Indoles, Metabolome, Metabolomics, Methylamines, Microbiota, Translational Research, Biomedical, Tryptophan, TyrosineAdded May 6, 2016
17 MeSH Terms
GABAC receptor binding of quantum-dot conjugates of variable ligand valency.
Gussin HA, Tomlinson ID, Muni NJ, Little DM, Qian H, Rosenthal SJ, Pepperberg DR
(2010) Bioconjug Chem 21
: 1455-64MeSH Terms: Binding Sites, Cadmium Compounds, Fluorescence, Ligands, Methylamines, Molecular Structure, Muscimol, Polyethylene Glycols, Quantum Dots, Receptors, GABA, Selenium Compounds, Sulfides, Zinc CompoundsAdded May 27, 2014
13 MeSH Terms
A liquid chromatography-tandem mass spectrometry method for measurement of N-modified phosphatidylethanolamines.
Guo L, Amarnath V, Davies SS
(2010) Anal Biochem 405
: 236-45MeSH Terms: Arachidonic Acid, Cells, Cultured, Chromatography, Liquid, Hydrolysis, Methylamines, Phosphatidylethanolamines, Phosphatidylinositol Phosphates, Streptomyces, Tandem Mass SpectrometryAdded June 1, 2013
9 MeSH Terms
Sodium-bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport.
Lee S, Lee HJ, Yang HS, Thornell IM, Bevensee MO, Choi I
(2010) Exp Physiol 95
: 926-37MeSH Terms: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid, Ammonia, Animals, Anion Transport Proteins, Antiporters, Bicarbonates, Biological Transport, Cell Line, Chlorides, Gluconates, Hydrogen-Ion Concentration, Kidney Medulla, Kinetics, Loop of Henle, Membrane Potentials, Methylamines, Patch-Clamp Techniques, Quaternary Ammonium Compounds, Rats, SLC4A Proteins, Sodium, Sodium-Bicarbonate Symporters, Up-Regulation, XenopusAdded March 14, 2014
24 MeSH Terms
Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine.
Guengerich FP, Voehler M, Williams KM, Deng Z, Harris TM
(2002) Chem Res Toxicol 15
: 793-8MeSH Terms: Aflatoxin B1, Aldehydes, Buffers, Chromatography, High Pressure Liquid, Cyclization, Hydrogen-Ion Concentration, Mass Spectrometry, Methylamines, Nuclear Magnetic Resonance, Biomolecular, Spectrometry, Fluorescence, Spectrophotometry, UltravioletAdded March 5, 2014
11 MeSH Terms
Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity.
Webb DJ, Hussaini IM, Weaver AM, Atkins TL, Chu CT, Pizzo SV, Owens GK, Gonias SL
(1995) Eur J Biochem 234
: 714-22MeSH Terms: Animals, Carrier Proteins, Cell Division, Cells, Cultured, Glycoproteins, Inositol 1,4,5-Trisphosphate, LDL-Receptor Related Protein-Associated Protein, Low Density Lipoprotein Receptor-Related Protein-1, Methylamines, Mitogens, Muscle, Smooth, Vascular, Pertussis Toxin, Protein Binding, Rats, Rats, Sprague-Dawley, Receptors, Immunologic, Recombinant Proteins, Signal Transduction, Transforming Growth Factor beta, Trypsin, Virulence Factors, Bordetella, alpha-MacroglobulinsAdded March 5, 2014
22 MeSH Terms
ddAVP does not stimulate acute changes in levels of medullary trimethylamines in humans.
Avison MJ, Van Why SK, Siegel NJ
(1993) J Am Soc Nephrol 4
: 1379-84MeSH Terms: Adult, Deamino Arginine Vasopressin, Humans, Injections, Intravenous, Kidney Medulla, Magnetic Resonance Spectroscopy, Methylamines, Osmolar Concentration, Urine, Water-Electrolyte BalanceAdded December 10, 2013
10 MeSH Terms