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Diabetes medication regimens and patient clinical characteristics in the national patient-centered clinical research network, PCORnet.
Bachmann KN, Roumie CL, Wiese AD, Grijalva CG, Buse JB, Bradford R, Zalimeni EO, Knoepp P, Dard S, Morris HL, Donahoo WT, Fanous N, Fonseca V, Katalenich B, Choi S, Louzao D, O'Brien E, Cook MM, Rothman RL, Chakkalakal RJ
(2020) Pharmacol Res Perspect 8: e00637
MeSH Terms: Adult, Aged, Comorbidity, Diabetes Mellitus, Type 2, Dipeptidyl-Peptidase IV Inhibitors, Drug Therapy, Combination, Electronic Health Records, Female, Glucagon-Like Peptide-1 Receptor, Humans, Hyperlipidemias, Hypertension, Hypoglycemic Agents, Insulin, Male, Metformin, Middle Aged, Patient-Centered Care, Retrospective Studies, Sodium-Glucose Transporter 2 Inhibitors, Sulfonylurea Compounds, Thiazolidinediones, United States
Added March 29, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Hospitalization for Lactic Acidosis Among Patients With Reduced Kidney Function Treated With Metformin or Sulfonylureas.
Chu PY, Hackstadt AJ, Chipman J, Griffin MR, Hung AM, Greevy RA, Grijalva CG, Elasy T, Roumie CL
(2020) Diabetes Care 43: 1462-1470
MeSH Terms: Acidosis, Lactic, Aged, Cohort Studies, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Female, Glomerular Filtration Rate, Hospitalization, Humans, Hypoglycemic Agents, Male, Metformin, Middle Aged, Renal Insufficiency, Retrospective Studies, Sulfonylurea Compounds, United States, Veterans
Added March 29, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer's Disease.
Farr SA, Roesler E, Niehoff ML, Roby DA, McKee A, Morley JE
(2019) J Alzheimers Dis 68: 1699-1710
MeSH Terms: Alzheimer Disease, Animals, Disease Models, Animal, Maze Learning, Memory, Metformin, Mice, Neuroprotective Agents, Treatment Outcome
Added April 30, 2019
0 Communities
1 Members
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9 MeSH Terms
Preparation, preliminary pharmacokinetic and brain targeting study of metformin encapsulated W/O/W composite submicron emulsions promoted by borneol.
Hong L, Li X, Bao Y, Duvall CL, Zhang C, Chen W, Peng C
(2019) Eur J Pharm Sci 133: 160-166
MeSH Terms: Animals, Brain, Camphanes, Drug Compounding, Drug Delivery Systems, Drug Liberation, Emulsions, Female, Hypoglycemic Agents, Male, Metformin, Rats, Sprague-Dawley
Added April 10, 2019
0 Communities
1 Members
0 Resources
12 MeSH Terms
Recent metformin adherence and the risk of hypoglycaemia in the year following intensification with a sulfonylurea.
Min JY, Griffin MR, Chipman J, Hackstadt AJ, Greevy RA, Grijalva CG, Hung AM, Roumie CL
(2019) Diabet Med 36: 482-490
MeSH Terms: Aged, Cohort Studies, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Glycated Hemoglobin A, Humans, Hypoglycemia, Hypoglycemic Agents, Male, Medication Adherence, Metformin, Middle Aged, Retrospective Studies, Risk Factors, Sulfonylurea Compounds, Time Factors, Veterans
Added March 29, 2022
0 Communities
1 Members
0 Resources
MeSH Terms
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K
(2018) Nat Med 24: 1395-1406
MeSH Terms: Adenosine Monophosphate, Aminoimidazole Carboxamide, Animals, Base Sequence, Chickens, Disease Models, Animal, Fructose-Bisphosphatase, Glucose, Glucose Intolerance, Homeostasis, Humans, Hypoglycemia, Liver, Metformin, Mice, Inbred C57BL, Mutation, Obesity, Prodrugs, Ribonucleotides
Added March 26, 2019
1 Communities
1 Members
0 Resources
19 MeSH Terms
Metformin use and incidence cancer risk: evidence for a selective protective effect against liver cancer.
Murff HJ, Roumie CL, Greevy RA, Hackstadt AJ, McGowan LED, Hung AM, Grijalva CG, Griffin MR
(2018) Cancer Causes Control 29: 823-832
MeSH Terms: Aged, Carcinoma, Hepatocellular, Female, Humans, Hypoglycemic Agents, Incidence, Liver Neoplasms, Male, Metformin, Middle Aged, Proportional Hazards Models, Retrospective Studies, Risk, Sulfonylurea Compounds, United States, Veterans
Added July 27, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms
Comparative Safety of Sulfonylurea and Metformin Monotherapy on the Risk of Heart Failure: A Cohort Study.
Roumie CL, Min JY, D'Agostino McGowan L, Presley C, Grijalva CG, Hackstadt AJ, Hung AM, Greevy RA, Elasy T, Griffin MR
(2017) J Am Heart Assoc 6:
MeSH Terms: Aged, Biomarkers, Blood Glucose, Databases, Factual, Diabetes Mellitus, Female, Glycated Hemoglobin A, Heart Failure, Hospitalization, Humans, Hypoglycemic Agents, Male, Medicaid, Medicare, Metformin, Middle Aged, Retrospective Studies, Risk Assessment, Risk Factors, Sex Factors, Sulfonylurea Compounds, Time Factors, Treatment Outcome, United States, United States Department of Veterans Affairs, Veterans Health
Added July 27, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Comparative Effectiveness of Second-Line Agents for the Treatment of Diabetes Type 2 in Preventing Kidney Function Decline.
Hung AM, Roumie CL, Greevy RA, Grijalva CG, Liu X, Murff HJ, Ikizler TA, Griffin MR
(2016) Clin J Am Soc Nephrol 11: 2177-2185
MeSH Terms: Aged, Comparative Effectiveness Research, Creatinine, Diabetes Mellitus, Type 2, Drug Therapy, Combination, Female, Glomerular Filtration Rate, Glycated Hemoglobin A, Humans, Hypoglycemic Agents, Incidence, Insulin, Kidney Failure, Chronic, Male, Metformin, Middle Aged, Retrospective Studies, Sulfonylurea Compounds, Tennessee
Added July 27, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin.
Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM
(2016) Clin Pharmacol Ther 100: 537-547
MeSH Terms: Adult, Aged, Aged, 80 and over, Diabetes Mellitus, Type 2, Disease Progression, Female, Glycated Hemoglobin A, Humans, Hypoglycemic Agents, Longitudinal Studies, Male, Membrane Proteins, Metformin, Middle Aged, Nonlinear Dynamics, Organic Cation Transport Proteins, Organic Cation Transporter 2, Pharmacogenomic Variants, Polymorphism, Single Nucleotide, Tumor Suppressor Proteins, Young Adult
Added March 24, 2020
0 Communities
1 Members
0 Resources
21 MeSH Terms