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Results: 1 to 9 of 9

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Expression of human cytochrome P450 2B6 in Escherichia coli: characterization of catalytic activity and expression levels in human liver.
Hanna IH, Reed JR, Guengerich FP, Hollenberg PF
(2000) Arch Biochem Biophys 376: 206-16
MeSH Terms: Animals, Antibody Specificity, Aryl Hydrocarbon Hydroxylases, Binding Sites, Cytochrome P-450 CYP2B6, Cytochrome P-450 Enzyme System, Escherichia coli, Gene Expression, Humans, Immunohistochemistry, In Vitro Techniques, Kinetics, Mephenytoin, Microsomes, Liver, Oxidoreductases, N-Demethylating, Rabbits, Recombinant Proteins, Spectrophotometry, Substrate Specificity, Testosterone
Added March 5, 2014
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20 MeSH Terms
Genetic polymorphism of (S)-mephenytoin 4'-hydroxylation in populations of African descent.
Xie HG, Kim RB, Stein CM, Wilkinson GR, Wood AJ
(1999) Br J Clin Pharmacol 48: 402-8
MeSH Terms: Africa, Aryl Hydrocarbon Hydroxylases, Blacks, Cytochrome P-450 CYP2C19, Cytochrome P-450 Enzyme System, Gene Frequency, Genotype, Humans, Hydroxylation, Mephenytoin, Mixed Function Oxygenases, Phenotype, Polymorphism, Genetic
Added December 10, 2013
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13 MeSH Terms
Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations.
Inoue K, Yamazaki H, Imiya K, Akasaka S, Guengerich FP, Shimada T
(1997) Pharmacogenetics 7: 103-13
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Asians, Cytochrome P-450 CYP2C19, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, Genotype, Humans, Hydroxylation, Mephenytoin, Microsomes, Liver, Mixed Function Oxygenases, Polymorphism, Genetic, Steroid 16-alpha-Hydroxylase, Steroid Hydroxylases, Tolbutamide, Whites
Added May 26, 2014
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16 MeSH Terms
Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors.
Kaisary A, Smith P, Jaczq E, McAllister CB, Wilkinson GR, Ray WA, Branch RA
(1987) Cancer Res 47: 5488-93
MeSH Terms: Acetylation, Aged, Alcohol Drinking, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C19, Cytochrome P-450 CYP2D6, Debrisoquin, Disease Susceptibility, Female, Humans, Male, Mathematics, Mephenytoin, Middle Aged, Mixed Function Oxygenases, Phenotype, Risk Factors, Smoking, Urinary Bladder Neoplasms
Added March 5, 2014
0 Communities
1 Members
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19 MeSH Terms
Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation.
Knodell RG, Dubey RK, Wilkinson GR, Guengerich FP
(1988) J Pharmacol Exp Ther 245: 845-9
MeSH Terms: Cytochrome P-450 Enzyme System, Hexobarbital, Humans, Hydantoins, Hydroxylation, In Vitro Techniques, Liver, Male, Mephenytoin, Oxidation-Reduction, Polymorphism, Genetic
Added March 5, 2014
0 Communities
1 Members
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11 MeSH Terms
Genetic polymorphism of S-mephenytoin hydroxylation.
Wilkinson GR, Guengerich FP, Branch RA
(1989) Pharmacol Ther 43: 53-76
MeSH Terms: Animals, Humans, Hydantoins, Hydroxylation, Mephenytoin, Molecular Biology, Polymorphism, Genetic
Added March 5, 2014
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7 MeSH Terms
Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae.
Brian WR, Srivastava PK, Umbenhauer DR, Lloyd RS, Guengerich FP
(1989) Biochemistry 28: 4993-9
MeSH Terms: Catalysis, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, DNA, Electrophoresis, Gene Expression Regulation, Genetic Vectors, Hexobarbital, Humans, Liver, Mephenytoin, Mixed Function Oxygenases, Oxidation-Reduction, Plasmids, Saccharomyces cerevisiae, Spectrophotometry, Ultraviolet, Sulfaphenazole, Tolbutamide
Added March 5, 2014
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18 MeSH Terms
Scleroderma is associated with differences in individual routes of drug metabolism: a study with dapsone, debrisoquin, and mephenytoin.
May DG, Black CM, Olsen NJ, Csuka ME, Tanner SB, Bellino L, Porter JA, Wilkinson GR, Branch RA
(1990) Clin Pharmacol Ther 48: 286-95
MeSH Terms: Acetylation, Adult, Biotransformation, Dapsone, Debrisoquin, Disease Susceptibility, Female, Humans, Hydantoins, Hydroxylation, Isoquinolines, Logistic Models, London, Male, Mephenytoin, Middle Aged, Oxidation-Reduction, Scleroderma, Systemic, Tennessee
Added January 20, 2015
0 Communities
1 Members
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19 MeSH Terms
Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.
Srivastava PK, Yun CH, Beaune PH, Ged C, Guengerich FP
(1991) Mol Pharmacol 40: 69-79
MeSH Terms: Amino Acid Sequence, Aryl Hydrocarbon Hydroxylases, Chromatography, High Pressure Liquid, Cytochrome P-450 CYP2C19, Cytochrome P-450 Enzyme System, DNA, Humans, Mephenytoin, Microsomes, Liver, Mixed Function Oxygenases, Molecular Sequence Data, Saccharomyces cerevisiae, Sequence Homology, Nucleic Acid, Tolbutamide, Tritium
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms