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Results: 1 to 2 of 2

Publication Record


Isolation and molecular characterization of a novel type 3 reovirus from a child with meningitis.
Tyler KL, Barton ES, Ibach ML, Robinson C, Campbell JA, O'Donnell SM, Valyi-Nagy T, Clarke P, Wetzel JD, Dermody TS
(2004) J Infect Dis 189: 1664-75
MeSH Terms: Amino Acid Sequence, Animals, Animals, Newborn, Capsid Proteins, Cell Line, Cerebrospinal Fluid, Female, HeLa Cells, Humans, Infant, Mammalian orthoreovirus 3, Meningitis, Viral, Mice, Molecular Sequence Data, Reoviridae Infections, Sequence Analysis, DNA, Serotyping
Show Abstract · Added December 10, 2013
Mammalian reoviruses are non-enveloped viruses that contain a segmented, double-stranded RNA genome. Reoviruses infect most mammalian species, although infection with these viruses in humans is usually asymptomatic. We report the isolation of a novel reovirus strain from a 6.5-week-old child with meningitis. Hemagglutination and neutralization assays indicated that the isolate is a serotype 3 strain, leading to the designation T3/Human/Colorado/1996 (T3C/96). Sequence analysis of the T3C/96 S1 gene segment, which encodes the viral attachment protein, sigma 1, confirmed the serotype assignment for this strain and indicated that T3C/96 is a novel reovirus isolate. T3C/96 is capable of systemic spread in newborn mice after peroral inoculation and produces lethal encephalitis. These results suggest that serotype 3 reoviruses can cause meningitis in humans.
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1 Members
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17 MeSH Terms
Differential diagnosis of acute meningitis. An analysis of the predictive value of initial observations.
Spanos A, Harrell FE, Durack DT
(1989) JAMA 262: 2700-7
MeSH Terms: Acute Disease, Adolescent, Adult, Aged, Antigens, Bacterial, Bacterial Infections, Blood Glucose, Cerebrospinal Fluid Proteins, Child, Child, Preschool, Diagnosis, Differential, Glucose, Humans, Infant, Infant, Newborn, Leukocyte Count, Logistic Models, Meningitis, Meningitis, Viral, Middle Aged, Predictive Value of Tests, Seasons
Show Abstract · Added February 28, 2014
We analyzed data from the records of 422 patients with acute bacterial or viral meningitis. A cerebrospinal fluid (CSF) glucose level less than 1.9 mmol/L, a CSF-blood glucose ratio less than 0.23, a CSF protein level greater than 2.2 g/L, more than 2000 x 10(6)/L CSF leukocytes, or more than 1180 x 10(6)/L CSF polymorphonuclear leukocytes were individual predictors of bacterial infection with 99% certainty or better. Although any one of these tests could rule in bacterial meningitis with high probability, none could rule it out. To better predict whether a patient has bacterial vs viral infection, we developed a logistic multiple regression model using CSF-blood glucose ratio, total polymorphonuclear leukocyte count in CSF, age, and month of onset. This proved highly reliable when validated in an independent test sample, with an area under receiver operating characteristic curve of 0.97. The model should allow physicians to differentiate between acute viral and acute bacterial meningitis with greater accuracy.
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1 Members
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22 MeSH Terms