Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate.
Dixit S, Fessel JP, Harrison FE
(2017) Free Radic Biol Med 112
: 515-523MeSH Terms: Adenosine Diphosphate, Adenosine Triphosphate, Alzheimer Disease, Amyloid beta-Protein Precursor, Animals, Antioxidants, Ascorbic Acid, Biological Transport, Disease Models, Animal, Female, Gene Expression Regulation, Heterozygote, Humans, Male, Membrane Potential, Mitochondrial, Mice, Mice, Transgenic, Mitochondria, Mutation, Oxidative Stress, Oxygen Consumption, Presenilin-1, Reactive Oxygen Species, Signal Transduction, Sodium-Coupled Vitamin C TransportersAdded March 14, 2018
25 MeSH Terms
TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion.
Dadi PK, Luo B, Vierra NC, Jacobson DA
(2015) Mol Endocrinol 29
: 777-87MeSH Terms: Animals, Calcium Signaling, Cells, Cultured, Female, Gene Expression, Glucagon, Glucagon-Secreting Cells, Glucose, Humans, Male, Membrane Potential, Mitochondrial, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Potassium Channels, Tandem Pore DomainAdded April 28, 2015
15 MeSH Terms
Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy-consuming redox circuit.
Fisher-Wellman KH, Lin CT, Ryan TE, Reese LR, Gilliam LA, Cathey BL, Lark DS, Smith CD, Muoio DM, Neufer PD
(2015) Biochem J 467
: 271-80MeSH Terms: Animals, Enzyme Inhibitors, Hydrogen Peroxide, Membrane Potential, Mitochondrial, Mice, Mitochondria, Muscle, Mitochondrial Proteins, NADP, NADP Transhydrogenase, AB-Specific, Oxidation-Reduction, Pyruvate Dehydrogenase ComplexAdded January 26, 2016
11 MeSH Terms
PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper.
Aboud AA, Tidball AM, Kumar KK, Neely MD, Han B, Ess KC, Hong CC, Erikson KM, Hedera P, Bowman AB
(2015) Neurobiol Dis 73
: 204-12MeSH Terms: Adult, Cadmium, Cell Line, Copper, Genetic Predisposition to Disease, Humans, Induced Pluripotent Stem Cells, Male, Manganese, Membrane Potential, Mitochondrial, Methylmercury Compounds, Mitochondria, Mutation, Neural Stem Cells, Parkinson Disease, Risk Factors, Ubiquitin-Protein LigasesAdded December 16, 2014
17 MeSH Terms
Acyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer.
Harris FT, Rahman SM, Hassanein M, Qian J, Hoeksema MD, Chen H, Eisenberg R, Chaurand P, Caprioli RM, Shiota M, Massion PP
(2014) Cancer Prev Res (Phila) 7
: 748-57MeSH Terms: Acetyl Coenzyme A, Adenocarcinoma, Adenosine Triphosphate, Apoptosis, Blotting, Western, Bronchi, Carcinoma in Situ, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Cell Proliferation, Cells, Cultured, Diazepam Binding Inhibitor, Humans, Immunoenzyme Techniques, Lung Neoplasms, Membrane Potential, Mitochondrial, Oxidation-Reduction, Palmitic Acid, Spectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAdded May 20, 2014
19 MeSH Terms
Loss of mitochondrial protein Fus1 augments host resistance to Acinetobacter baumannii infection.
Hood MI, Uzhachenko R, Boyd K, Skaar EP, Ivanova AV
(2013) Infect Immun 81
: 4461-9MeSH Terms: Acinetobacter Infections, Acinetobacter baumannii, Animals, Bronchoalveolar Lavage Fluid, Interleukin-10, Interleukin-17, Lung, Macrophages, Male, Membrane Potential, Mitochondrial, Mice, Mice, Knockout, NF-kappa B, Neutrophils, Phosphatidylinositol 3-Kinase, Pneumonia, Bacterial, Proto-Oncogene Proteins c-akt, Reactive Oxygen Species, TOR Serine-Threonine Kinases, Tumor Suppressor ProteinsAdded March 7, 2014
20 MeSH Terms
Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress.
Nazarewicz RR, Dikalova AE, Bikineyeva A, Dikalov SI
(2013) Am J Physiol Heart Circ Physiol 305
: H1131-40MeSH Terms: Animals, Aorta, Blood Pressure, Cell Respiration, Cells, Cultured, Diazoxide, Electron Transport Complex I, Electron Transport Complex II, Endothelial Cells, Humans, Membrane Glycoproteins, Membrane Potential, Mitochondrial, Mice, Mitochondria, NADPH Oxidase 2, NADPH Oxidases, Oxidative Stress, Potassium Channels, Superoxides, Vasodilator AgentsAdded March 30, 2014
20 MeSH Terms
Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects.
Aboud AA, Tidball AM, Kumar KK, Neely MD, Ess KC, Erikson KM, Bowman AB
(2012) Neurotoxicology 33
: 1443-1449MeSH Terms: Biosensing Techniques, Case-Control Studies, Cell Line, Cell Survival, Chlorides, Dose-Response Relationship, Drug, Environmental Pollutants, Gene-Environment Interaction, Genetic Predisposition to Disease, Humans, Induced Pluripotent Stem Cells, Manganese Compounds, Manganese Poisoning, Membrane Potential, Mitochondrial, Mitochondria, Mutation, Neural Stem Cells, Neurologic Examination, Parkinson Disease, Parkinson Disease, Secondary, Phenotype, Reactive Oxygen Species, Risk Factors, Time Factors, Ubiquitin-Protein LigasesAdded August 25, 2013
25 MeSH Terms
nNOS mediated mitochondrial injury in LPS stimulated oligodendrocytes.
Yao SY, Natarajan C, Sriram S
(2012) Mitochondrion 12
: 336-44MeSH Terms: Animals, Apoptosis, Cell Survival, Cells, Cultured, Cytochromes c, Electron Transport Complex I, Electron Transport Complex IV, Lipopolysaccharides, Membrane Potential, Mitochondrial, Mitochondria, Nitric Oxide Synthase, Oligodendroglia, Rats, Rats, Sprague-DawleyAdded April 18, 2017
14 MeSH Terms
Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein.
Park D, Han CZ, Elliott MR, Kinchen JM, Trampont PC, Das S, Collins S, Lysiak JJ, Hoehn KL, Ravichandran KS
(2011) Nature 477
: 220-4MeSH Terms: Animals, Apoptosis, Cell Line, Cell Size, Cells, Cultured, Ion Channels, Membrane Potential, Mitochondrial, Mice, Mitochondrial Proteins, Phagocytes, Phagocytosis, Thymus Gland, Uncoupling Protein 2Added July 22, 2020