Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress.
Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE
(2019) Cell Stem Cell 25
: 814-829.e6MeSH Terms: Animals, Cell Division, Cell Lineage, Cells, Cultured, Female, Flow Cytometry, Fluorescence, Immunohistochemistry, Male, Membrane Glycoproteins, Mice, Mouth Mucosa, Nerve Tissue Proteins, Stem Cells, Wound HealingAdded March 3, 2020
15 MeSH Terms
Targeted mobilization of Lrig1 gastric epithelial stem cell populations by a carcinogenic type IV secretion system.
Wroblewski LE, Choi E, Petersen C, Delgado AG, Piazuelo MB, Romero-Gallo J, Lantz TL, Zavros Y, Coffey RJ, Goldenring JR, Zemper AE, Peek RM
(2019) Proc Natl Acad Sci U S A 116
: 19652-19658MeSH Terms: Adenocarcinoma, Animals, Carcinogenesis, Disease Models, Animal, Epithelial Cells, Female, Gastric Mucosa, Gastritis, Helicobacter Infections, Helicobacter pylori, Humans, Male, Membrane Glycoproteins, Mice, Mice, Knockout, Nerve Tissue Proteins, Precancerous Conditions, Primary Cell Culture, Risk Factors, Stem Cells, Stomach, Stomach Neoplasms, Type IV Secretion SystemsAdded September 27, 2019
23 MeSH Terms
Mechanism of Hyperkalemia-Induced Metabolic Acidosis.
Harris AN, Grimm PR, Lee HW, Delpire E, Fang L, Verlander JW, Welling PA, Weiner ID
(2018) J Am Soc Nephrol 29
: 1411-1425MeSH Terms: Acidosis, Aldosterone, Amiloride, Ammonia, Animals, Cation Transport Proteins, Diuretics, Glutaminase, Hydrochlorothiazide, Hydrogen-Ion Concentration, Hyperkalemia, Kidney Tubules, Distal, Kidney Tubules, Proximal, Membrane Glycoproteins, Mice, Mice, Knockout, Protein-Serine-Threonine Kinases, Proton-Translocating ATPases, UrinalysisShow Abstract · Added April 3, 2018
Hyperkalemia in association with metabolic acidosis that are out of proportion to changes in glomerular filtration rate defines type 4 renal tubular acidosis (RTA), the most common RTA observed, but the molecular mechanisms underlying the associated metabolic acidosis are incompletely understood. We sought to determine whether hyperkalemia directly causes metabolic acidosis and, if so, the mechanisms through which this occurs. We studied a genetic model of hyperkalemia that results from early distal convoluted tubule (DCT)-specific overexpression of constitutively active Ste20/SPS1-related proline-alanine-rich kinase (DCT-CA-SPAK). DCT-CA-SPAK mice developed hyperkalemia in association with metabolic acidosis and suppressed ammonia excretion; however, titratable acid excretion and urine pH were unchanged compared with those in wild-type mice. Abnormal ammonia excretion in DCT-CA-SPAK mice associated with decreased proximal tubule expression of the ammonia-generating enzymes phosphate-dependent glutaminase and phosphoenolpyruvate carboxykinase and overexpression of the ammonia-recycling enzyme glutamine synthetase. These mice also had decreased expression of the ammonia transporter family member Rhcg and decreased apical polarization of H-ATPase in the inner stripe of the outer medullary collecting duct. Correcting the hyperkalemia by treatment with hydrochlorothiazide corrected the metabolic acidosis, increased ammonia excretion, and normalized ammoniagenic enzyme and Rhcg expression in DCT-CA-SPAK mice. In wild-type mice, induction of hyperkalemia by administration of the epithelial sodium channel blocker benzamil caused hyperkalemia and suppressed ammonia excretion. Hyperkalemia decreases proximal tubule ammonia generation and collecting duct ammonia transport, leading to impaired ammonia excretion that causes metabolic acidosis.
Copyright © 2018 by the American Society of Nephrology.
19 MeSH Terms
The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
King LB, Fusco ML, Flyak AI, Ilinykh PA, Huang K, Gunn B, Kirchdoerfer RN, Hastie KM, Sangha AK, Meiler J, Alter G, Bukreyev A, Crowe JE, Saphire EO
(2018) Cell Host Microbe 23
: 101-109.e4MeSH Terms: Agrobacterium tumefaciens, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Binding Sites, Carrier Proteins, Cell Line, Chlorocebus aethiops, Crystallography, X-Ray, Drosophila melanogaster, Humans, Intracellular Signaling Peptides and Proteins, Marburgvirus, Membrane Glycoproteins, Receptors, Virus, Tobacco, Vero Cells, Viral Envelope Proteins, Viral Fusion Proteins, Virus AttachmentAdded March 17, 2018
21 MeSH Terms
GRP94 Is an Essential Regulator of Pancreatic β-Cell Development, Mass, and Function in Male Mice.
Kim DS, Song L, Wang J, Wu H, Gu G, Sugi Y, Li Z, Wang H
(2018) Endocrinology 159
: 1062-1073MeSH Terms: Animals, Cell Count, Cell Differentiation, Cell Proliferation, Cells, Cultured, Embryo, Nonmammalian, Glucose Intolerance, HEK293 Cells, Humans, Insulin-Secreting Cells, Male, Membrane Glycoproteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Organ Size, PancreasAdded December 4, 2020
Cytomegalovirus (CMV) Epitope-Specific CD4 T Cells Are Inflated in HIV CMV Subjects.
Abana CO, Pilkinton MA, Gaudieri S, Chopra A, McDonnell WJ, Wanjalla C, Barnett L, Gangula R, Hager C, Jung DK, Engelhardt BG, Jagasia MH, Klenerman P, Phillips EJ, Koelle DM, Kalams SA, Mallal SA
(2017) J Immunol 199
: 3187-3201MeSH Terms: ADP-ribosyl Cyclase 1, CD4-Positive T-Lymphocytes, Cytomegalovirus, Cytomegalovirus Infections, Epitopes, T-Lymphocyte, Female, HIV Infections, HIV-1, HLA-DR7 Antigen, Humans, Immunologic Memory, Male, Membrane Glycoproteins, Viral ProteinsAdded March 30, 2020
Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach.
Choi E, Lantz TL, Vlacich G, Keeley TM, Samuelson LC, Coffey RJ, Goldenring JR, Powell AE
(2018) Gut 67
: 1595-1605MeSH Terms: Animals, Biomarkers, Cell Lineage, Disease Models, Animal, Gastric Mucosa, Membrane Glycoproteins, Mice, Mice, Knockout, Nerve Tissue Proteins, Predictive Value of Tests, Sensitivity and Specificity, Stem Cells, Stomach Ulcer, Wound HealingAdded September 27, 2017
14 MeSH Terms
CD318 is a ligand for CD6.
Enyindah-Asonye G, Li Y, Ruth JH, Spassov DS, Hebron KE, Zijlstra A, Moasser MM, Wang B, Singer NG, Cui H, Ohara RA, Rasmussen SM, Fox DA, Lin F
(2017) Proc Natl Acad Sci U S A 114
: E6912-E6921MeSH Terms: A549 Cells, Animals, Antigens, CD, Antigens, Differentiation, T-Lymphocyte, Antigens, Neoplasm, Arthritis, Rheumatoid, Cell Adhesion Molecules, Cell Line, Cell Line, Tumor, Encephalomyelitis, Autoimmune, Experimental, Humans, Ligands, Membrane Glycoproteins, Mice, Inbred C57BL, Mice, Knockout, Neoplasm Proteins, Synovial Membrane, T-LymphocytesAdded March 22, 2018
18 MeSH Terms
The nature and biology of basement membranes.
Pozzi A, Yurchenco PD, Iozzo RV
(2017) Matrix Biol 57-58
: 1-11MeSH Terms: Agrin, Animals, Basement Membrane, Bone Diseases, Developmental, Collagen Type IV, Diabetic Nephropathies, Extracellular Matrix, Gene Expression Regulation, Heparan Sulfate Proteoglycans, Humans, Laminin, Lupus Nephritis, Mechanotransduction, Cellular, Membrane Glycoproteins, Mutation, Protein IsoformsAdded March 26, 2017
16 MeSH Terms
Identification and Functional Assessment of Age-Dependent Truncations to Cx46 and Cx50 in the Human Lens.
Slavi N, Wang Z, Harvey L, Schey KL, Srinivas M
(2016) Invest Ophthalmol Vis Sci 57
: 5714-5722MeSH Terms: Aging, Cataract, Cell Membrane Permeability, Cells, Cultured, Connexins, Humans, Lens, Crystalline, Membrane Glycoproteins, Middle Aged, Patch-Clamp Techniques, Tandem Mass SpectrometryAdded May 6, 2017
11 MeSH Terms