Loss of CXCR4 in Myeloid Cells Enhances Antitumor Immunity and Reduces Melanoma Growth through NK Cell and FASL Mechanisms.
Yang J, Kumar A, Vilgelm AE, Chen SC, Ayers GD, Novitskiy SV, Joyce S, Richmond A
(2018) Cancer Immunol Res 6
: 1186-1198MeSH Terms: Animals, Bone Marrow Transplantation, Cell Line, Tumor, Cytotoxicity, Immunologic, Fas Ligand Protein, Interleukin-18, Killer Cells, Natural, Macrophages, Melanoma, Experimental, Mice, Inbred C57BL, Mice, Transgenic, Neutrophils, Receptors, CXCR4Added December 20, 2018
13 MeSH Terms
Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α dendritic cells.
Parekh VV, Pabbisetty SK, Wu L, Sebzda E, Martinez J, Zhang J, Van Kaer L
(2017) Proc Natl Acad Sci U S A 114
: E6371-E6380MeSH Terms: Animals, Antigen Presentation, Autophagy, Autophagy-Related Proteins, CD8 Antigens, CD8-Positive T-Lymphocytes, Cells, Cultured, Class III Phosphatidylinositol 3-Kinases, Cross-Priming, Cytokines, Dendritic Cells, Endocytosis, Histocompatibility Antigens Class I, Melanoma, Experimental, Membrane Proteins, Mice, Mice, Knockout, PhagocytosisAdded March 26, 2019
IL-17RC is critically required to maintain baseline A20 production to repress JNK isoform-dependent tumor-specific proliferation.
Yan C, Lei Y, Lin TJ, Hoskin DW, Ma A, Wang J
(2017) Oncotarget 8
: 43153-43168MeSH Terms: Animals, Cell Line, Tumor, Cell Proliferation, Female, Interleukin-17, Isoenzymes, MAP Kinase Kinase 4, Male, Mammary Neoplasms, Experimental, Melanoma, Melanoma, Experimental, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Receptors, Interleukin-17, Signal Transduction, Transcription Factors, Transfection, Tumor Necrosis Factor alpha-Induced Protein 3Added May 15, 2018
Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells.
Vilgelm AE, Pawlikowski JS, Liu Y, Hawkins OE, Davis TA, Smith J, Weller KP, Horton LW, McClain CM, Ayers GD, Turner DC, Essaka DC, Stewart CF, Sosman JA, Kelley MC, Ecsedy JA, Johnston JN, Richmond A
(2015) Cancer Res 75
: 181-93MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Aurora Kinase A, Azepines, Cell Proliferation, Humans, Imidazoles, Melanoma, Melanoma, Experimental, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Nude, Piperazines, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-mdm2, PyrimidinesAdded January 20, 2015
17 MeSH Terms
Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response.
Yang J, Hawkins OE, Barham W, Gilchuk P, Boothby M, Ayers GD, Joyce S, Karin M, Yull FE, Richmond A
(2014) Cancer Res 74
: 7274-84MeSH Terms: Animals, CD8-Positive T-Lymphocytes, Dendritic Cells, Humans, I-kappa B Kinase, Immunity, Innate, Macrophages, Melanoma, Experimental, Mice, Mice, Knockout, Myeloid Cells, NF-kappa B, Proto-Oncogene Proteins B-raf, Signal Transduction, Tumor MicroenvironmentAdded December 17, 2014
15 MeSH Terms
MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis.
Cook RS, Jacobsen KM, Wofford AM, DeRyckere D, Stanford J, Prieto AL, Redente E, Sandahl M, Hunter DM, Strunk KE, Graham DK, Earp HS
(2013) J Clin Invest 123
: 3231-42MeSH Terms: Animals, CD8-Positive T-Lymphocytes, Colonic Neoplasms, Cytokines, Disease Resistance, Female, Gene Expression Regulation, Neoplastic, Leukocytes, Male, Mammary Neoplasms, Experimental, Melanoma, Experimental, Mice, Mice, Inbred C57BL, Mice, Knockout, Neoplasm Transplantation, Proto-Oncogene Proteins, Receptor Protein-Tyrosine Kinases, Transcriptome, Tumor Burden, Tumor Microenvironment, c-Mer Tyrosine KinaseAdded March 7, 2014
21 MeSH Terms
Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence.
Liu Y, Hawkins OE, Su Y, Vilgelm AE, Sobolik T, Thu YM, Kantrow S, Splittgerber RC, Short S, Amiri KI, Ecsedy JA, Sosman JA, Kelley MC, Richmond A
(2013) EMBO Mol Med 5
: 149-66MeSH Terms: Animals, Antineoplastic Agents, Ataxia Telangiectasia Mutated Proteins, Aurora Kinases, Azepines, Benzazepines, Cell Cycle Proteins, Cell Line, Tumor, Cell Proliferation, Cellular Senescence, Checkpoint Kinase 2, DNA Damage, DNA-Binding Proteins, Humans, Melanoma, Experimental, Mice, Mice, Nude, NF-kappa B, Polyploidy, Protein Kinase Inhibitors, Protein Serine-Threonine Kinases, Pyrimidines, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, Xenograft Model Antitumor AssaysAdded June 14, 2013
25 MeSH Terms
Agonistic antibody to CD40 boosts the antitumor activity of adoptively transferred T cells in vivo.
Liu C, Lewis CM, Lou Y, Xu C, Peng W, Yang Y, Gelbard AH, Lizée G, Zhou D, Overwijk WW, Hwu P
(2012) J Immunother 35
: 276-82MeSH Terms: Adoptive Transfer, Animals, Antibodies, Monoclonal, Antigen Presentation, B7-1 Antigen, B7-2 Antigen, Bone Marrow Cells, CD40 Antigens, Cell Line, Female, Interleukin-2, Melanoma, Experimental, Mice, Mice, Inbred C57BL, Mice, Knockout, T-Lymphocytes, gp100 Melanoma AntigenAdded April 11, 2014
17 MeSH Terms
NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway.
Thu YM, Su Y, Yang J, Splittgerber R, Na S, Boyd A, Mosse C, Simons C, Richmond A
(2012) Oncogene 31
: 2580-92MeSH Terms: Animals, Apoptosis, Cell Line, Tumor, Cell Proliferation, Cell Survival, Cyclin D2, Down-Regulation, Enzyme Activation, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Genes, bcl-2, Genes, myc, Humans, Melanoma, Melanoma, Experimental, Mice, Neoplasm Metastasis, Protein Serine-Threonine Kinases, RNA, Small Interfering, Signal Transduction, beta CateninAdded June 14, 2013
21 MeSH Terms
Preconditioned endothelial progenitor cells reduce formation of melanoma metastases through SPARC-driven cell-cell interactions and endocytosis.
Defresne F, Bouzin C, Grandjean M, Dieu M, Raes M, Hatzopoulos AK, Kupatt C, Feron O
(2011) Cancer Res 71
: 4748-57MeSH Terms: Animals, Breast Neoplasms, Cell Communication, Cell Line, Tumor, Culture Media, Conditioned, Endocytosis, Endothelial Cells, Female, Humans, Male, Melanoma, Experimental, Mice, Mice, Inbred BALB C, Mice, Nude, Neoplasm Metastasis, Osteonectin, Stem Cell Transplantation, Stem CellsAdded November 13, 2012
18 MeSH Terms