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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 21

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Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma.
Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss WA, Rodriguez C, Mehrdad N, Nguyen DM, Ayad NG, Rai P, Capobianco AJ, Robbins DJ
(2017) Oncogene 36: 6306-6314
MeSH Terms: Anilides, Animals, Cell Line, Tumor, Cerebellar Neoplasms, Disease Models, Animal, HEK293 Cells, Hedgehog Proteins, Humans, Male, Medulloblastoma, Mice, Mice, Transgenic, Pyridines, Random Allocation, SOXB1 Transcription Factors, Small Molecule Libraries, TRPC Cation Channels, Transfection, Tumor Suppressor Protein p53, Veratrum Alkaloids, Wnt Proteins, Wnt Signaling Pathway
Added July 18, 2017
0 Communities
1 Members
0 Resources
22 MeSH Terms
WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma.
Wen J, Lee J, Malhotra A, Nahta R, Arnold AR, Buss MC, Brown BD, Maier C, Kenney AM, Remke M, Ramaswamy V, Taylor MD, Castellino RC
(2016) Oncogene 35: 5552-5564
MeSH Terms: Animals, Biomarkers, Cell Cycle, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, Cerebellar Neoplasms, Gene Knockdown Techniques, Hedgehog Proteins, Humans, Medulloblastoma, Mice, Mice, Transgenic, NIH 3T3 Cells, Neural Stem Cells, Protein Phosphatase 2C, Signal Transduction, Tumor Suppressor Protein p53
Added April 25, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms
Active medulloblastoma enhancers reveal subgroup-specific cellular origins.
Lin CY, Erkek S, Tong Y, Yin L, Federation AJ, Zapatka M, Haldipur P, Kawauchi D, Risch T, Warnatz HJ, Worst BC, Ju B, Orr BA, Zeid R, Polaski DR, Segura-Wang M, Waszak SM, Jones DT, Kool M, Hovestadt V, Buchhalter I, Sieber L, Johann P, Chavez L, Gröschel S, Ryzhova M, Korshunov A, Chen W, Chizhikov VV, Millen KJ, Amstislavskiy V, Lehrach H, Yaspo ML, Eils R, Lichter P, Korbel JO, Pfister SM, Bradner JE, Northcott PA
(2016) Nature 530: 57-62
MeSH Terms: Animals, Cerebellar Neoplasms, Enhancer Elements, Genetic, Female, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Genes, Neoplasm, Genes, Reporter, Humans, Male, Medulloblastoma, Mice, Reproducibility of Results, Transcription Factors, Zebrafish
Added February 15, 2016
0 Communities
1 Members
0 Resources
15 MeSH Terms
YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.
Dey A, Robitaille M, Remke M, Maier C, Malhotra A, Gregorieff A, Wrana JL, Taylor MD, Angers S, Kenney AM
(2016) Oncogene 35: 4256-68
MeSH Terms: Animals, Cell Line, Tumor, Cell Proliferation, Cerebellar Neoplasms, Cerebellum, Gene Expression Regulation, Neoplastic, Hedgehog Proteins, Insulin-Like Growth Factor II, Medulloblastoma, Mice, Neural Stem Cells, Signal Transduction, Y-Box-Binding Protein 1
Added April 25, 2016
0 Communities
1 Members
0 Resources
13 MeSH Terms
Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression.
Chiang C, Ihrie RA
(2014) Cancer Cell 26: 773-774
MeSH Terms: Animals, DNA-Binding Proteins, Humans, Medulloblastoma, Neurogenesis, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-6, Repressor Proteins, Signal Transduction, Sirtuin 1
Added January 26, 2015
1 Communities
2 Members
0 Resources
10 MeSH Terms
Pyrvinium attenuates Hedgehog signaling downstream of smoothened.
Li B, Fei DL, Flaveny CA, Dahmane N, Baubet V, Wang Z, Bai F, Pei XH, Rodriguez-Blanco J, Hang B, Orton D, Han L, Wang B, Capobianco AJ, Lee E, Robbins DJ
(2014) Cancer Res 74: 4811-21
MeSH Terms: Animals, Carcinoma, Basal Cell, Casein Kinase Ialpha, Cell Line, HEK293 Cells, Hedgehog Proteins, Humans, Medulloblastoma, Mice, Mice, Nude, NIH 3T3 Cells, Oncogene Proteins, Pyrvinium Compounds, Receptors, G-Protein-Coupled, Signal Transduction, Trans-Activators, Transcription Factors, Zinc Finger Protein GLI1
Added November 2, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Cytogenetic prognostication within medulloblastoma subgroups.
Shih DJ, Northcott PA, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang X, Dubuc AM, Garzia L, Peacock J, Mack SC, Wu X, Rolider A, Morrissy AS, Cavalli FM, Jones DT, Zitterbart K, Faria CC, Schüller U, Kren L, Kumabe T, Tominaga T, Shin Ra Y, Garami M, Hauser P, Chan JA, Robinson S, Bognár L, Klekner A, Saad AG, Liau LM, Albrecht S, Fontebasso A, Cinalli G, De Antonellis P, Zollo M, Cooper MK, Thompson RC, Bailey S, Lindsey JC, Di Rocco C, Massimi L, Michiels EM, Scherer SW, Phillips JJ, Gupta N, Fan X, Muraszko KM, Vibhakar R, Eberhart CG, Fouladi M, Lach B, Jung S, Wechsler-Reya RJ, Fèvre-Montange M, Jouvet A, Jabado N, Pollack IF, Weiss WA, Lee JY, Cho BK, Kim SK, Wang KC, Leonard JR, Rubin JB, de Torres C, Lavarino C, Mora J, Cho YJ, Tabori U, Olson JM, Gajjar A, Packer RJ, Rutkowski S, Pomeroy SL, French PJ, Kloosterhof NK, Kros JM, Van Meir EG, Clifford SC, Bourdeaut F, Delattre O, Doz FF, Hawkins CE, Malkin D, Grajkowska WA, Perek-Polnik M, Bouffet E, Rutka JT, Pfister SM, Taylor MD
(2014) J Clin Oncol 32: 886-96
MeSH Terms: Adolescent, Biomarkers, Tumor, Child, Child, Preschool, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 14, Cytogenetics, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Hedgehog Proteins, Humans, In Situ Hybridization, Fluorescence, Infant, Kruppel-Like Transcription Factors, Male, Medulloblastoma, Nuclear Proteins, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Proto-Oncogene Proteins c-myc, Reproducibility of Results, Risk Assessment, Risk Factors, Tissue Array Analysis, Wnt Proteins, Young Adult, Zinc Finger Protein Gli2
Added March 21, 2014
0 Communities
1 Members
0 Resources
29 MeSH Terms
Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma.
Crowther AJ, Gama V, Bevilacqua A, Chang SX, Yuan H, Deshmukh M, Gershon TR
(2013) J Neurosci 33: 18098-108
MeSH Terms: Animals, Apoptosis, Cells, Cultured, Female, Male, Medulloblastoma, Mice, Mice, Inbred C57BL, Mice, Inbred ICR, Mice, Knockout, Neural Stem Cells, Protein Binding, Time Factors, bcl-2-Associated X Protein, bcl-X Protein
Added October 26, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.
Remke M, Ramaswamy V, Peacock J, Shih DJ, Koelsche C, Northcott PA, Hill N, Cavalli FM, Kool M, Wang X, Mack SC, Barszczyk M, Morrissy AS, Wu X, Agnihotri S, Luu B, Jones DT, Garzia L, Dubuc AM, Zhukova N, Vanner R, Kros JM, French PJ, Van Meir EG, Vibhakar R, Zitterbart K, Chan JA, Bognár L, Klekner A, Lach B, Jung S, Saad AG, Liau LM, Albrecht S, Zollo M, Cooper MK, Thompson RC, Delattre OO, Bourdeaut F, Doz FF, Garami M, Hauser P, Carlotti CG, Van Meter TE, Massimi L, Fults D, Pomeroy SL, Kumabe T, Ra YS, Leonard JR, Elbabaa SK, Mora J, Rubin JB, Cho YJ, McLendon RE, Bigner DD, Eberhart CG, Fouladi M, Wechsler-Reya RJ, Faria CC, Croul SE, Huang A, Bouffet E, Hawkins CE, Dirks PB, Weiss WA, Schüller U, Pollack IF, Rutkowski S, Meyronet D, Jouvet A, Fèvre-Montange M, Jabado N, Perek-Polnik M, Grajkowska WA, Kim SK, Rutka JT, Malkin D, Tabori U, Pfister SM, Korshunov A, von Deimling A, Taylor MD
(2013) Acta Neuropathol 126: 917-29
MeSH Terms: Adolescent, Adult, Brain Neoplasms, Child, Child, Preschool, DNA Mutational Analysis, Female, Gene Expression Profiling, Genotype, Humans, Infant, Male, Medulloblastoma, Middle Aged, Mutation, Prognosis, Promoter Regions, Genetic, Telomerase
Added March 7, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY
(2012) Genes Dev 26: 1780-96
MeSH Terms: Animals, COS Cells, Cell Cycle Checkpoints, Cell Proliferation, Cell Size, Cells, Cultured, Chlorocebus aethiops, Enzyme Activation, Ether-A-Go-Go Potassium Channels, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, HEK293 Cells, Humans, MAP Kinase Signaling System, Medulloblastoma, Mice, Mitosis, Survival Analysis
Added January 18, 2013
0 Communities
2 Members
0 Resources
19 MeSH Terms