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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 17

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Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.
Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T
(2019) JCI Insight 4:
MeSH Terms: Animals, Carcinogenesis, Cell Line, Tumor, Cell Proliferation, Cells, Cultured, Colitis, Ulcerative, Colon, Colorectal Neoplasms, Dextran Sulfate, Disease Models, Animal, Female, Humans, Intestinal Mucosa, Kaplan-Meier Estimate, Macrophages, Male, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Transgenic, Morpholines, Osteopontin, Primary Cell Culture, Prognosis, Survival Rate
Added November 6, 2019
1 Communities
1 Members
0 Resources
24 MeSH Terms
Selective mTORC2 Inhibitor Therapeutically Blocks Breast Cancer Cell Growth and Survival.
Werfel TA, Wang S, Jackson MA, Kavanaugh TE, Joly MM, Lee LH, Hicks DJ, Sanchez V, Ericsson PG, Kilchrist KV, Dimobi SC, Sarett SM, Brantley-Sieders DM, Cook RS, Duvall CL
(2018) Cancer Res 78: 1845-1858
MeSH Terms: Animals, Antineoplastic Agents, Cell Proliferation, Cell Survival, Disease Models, Animal, Female, Humans, Lapatinib, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Inbred BALB C, Mice, Nude, Nanoparticles, Protein Kinase Inhibitors, RNA, Small Interfering, Rapamycin-Insensitive Companion of mTOR Protein, Receptor, ErbB-2, Triple Negative Breast Neoplasms, Xenograft Model Antitumor Assays
Added March 14, 2018
0 Communities
2 Members
0 Resources
19 MeSH Terms
Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination.
Grier MD, West KL, Kelm ND, Fu C, Does MD, Parker B, McBrier E, Lagrange AH, Ess KC, Carson RP
(2017) PLoS One 12: e0188417
MeSH Terms: Animals, Cell Differentiation, Cell Proliferation, Central Nervous System, Gene Expression Regulation, Developmental, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Knockout, Myelin Sheath, Oligodendrocyte Precursor Cells, Rapamycin-Insensitive Companion of mTOR Protein, Signal Transduction, White Matter
Added March 14, 2018
0 Communities
2 Members
0 Resources
14 MeSH Terms
Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.
Morrison Joly M, Williams MM, Hicks DJ, Jones B, Sanchez V, Young CD, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS
(2017) Breast Cancer Res 19: 74
MeSH Terms: Animals, Breast Neoplasms, Cell Line, Tumor, Cell Movement, Disease Models, Animal, Female, Gene Amplification, Heterografts, Humans, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Transgenic, Neoplasm Metastasis, Neoplasm Staging, Prognosis, Proto-Oncogene Proteins c-akt, Rapamycin-Insensitive Companion of mTOR Protein, Receptor, ErbB-2, Signal Transduction, rac1 GTP-Binding Protein, rho Guanine Nucleotide Dissociation Inhibitor beta
Added April 15, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.
Sinagoga KL, Stone WJ, Schiesser JV, Schweitzer JI, Sampson L, Zheng Y, Wells JM
(2017) Development 144: 2402-2414
MeSH Terms: Animals, Animals, Newborn, Cell Aggregation, Islets of Langerhans, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Mice, Models, Biological, Morphogenesis, Multiprotein Complexes, Mutation, Signal Transduction, TOR Serine-Threonine Kinases
Added February 6, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
mTORC1 and mTORC2 in cancer and the tumor microenvironment.
Kim LC, Cook RS, Chen J
(2017) Oncogene 36: 2191-2201
MeSH Terms: Animals, Humans, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Multiprotein Complexes, Neoplasms, TOR Serine-Threonine Kinases, Tumor Microenvironment
Added March 29, 2017
1 Communities
2 Members
0 Resources
8 MeSH Terms
Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis.
Linton MF, Babaev VR, Huang J, Linton EF, Tao H, Yancey PG
(2016) Circ J 80: 2259-2268
MeSH Terms: Animals, Atherosclerosis, Endoplasmic Reticulum Stress, Humans, I-kappa B Kinase, Isoenzymes, Macrophages, Mechanistic Target of Rapamycin Complex 2, Mitogen-Activated Protein Kinase 8, Multiprotein Complexes, Proto-Oncogene Proteins c-akt, Signal Transduction, TOR Serine-Threonine Kinases, Unfolded Protein Response
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers.
Morrison Joly M, Hicks DJ, Jones B, Sanchez V, Estrada MV, Young C, Williams M, Rexer BN, Sarbassov dos D, Muller WJ, Brantley-Sieders D, Cook RS
(2016) Cancer Res 76: 4752-64
MeSH Terms: Animals, Blotting, Western, Breast Neoplasms, Carrier Proteins, Disease Progression, Drug Resistance, Neoplasm, Female, Heterografts, Humans, Kaplan-Meier Estimate, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Inbred BALB C, Mice, Nude, Multiprotein Complexes, Rapamycin-Insensitive Companion of mTOR Protein, Receptor, ErbB-2, Signal Transduction, TOR Serine-Threonine Kinases, Tissue Array Analysis
Added April 15, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons.
Meltzer S, Yadav S, Lee J, Soba P, Younger SH, Jin P, Zhang W, Parrish J, Jan LY, Jan YN
(2016) Neuron 89: 741-55
MeSH Terms: Animals, Animals, Genetically Modified, Cell Communication, Dendrites, Drosophila, Drosophila Proteins, Epidermis, Focal Adhesion Kinase 1, Gene Expression Regulation, Developmental, Green Fluorescent Proteins, Immunoprecipitation, Larva, Mechanistic Target of Rapamycin Complex 2, Molecular Biology, Multiprotein Complexes, Mutation, Nerve Tissue Proteins, Receptors, Cell Surface, Semaphorins, Sensory Receptor Cells, TOR Serine-Threonine Kinases, Transfection
Added February 9, 2016
1 Communities
0 Members
0 Resources
22 MeSH Terms
Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis.
Babaev VR, Ding L, Zhang Y, May JM, Lin PC, Fazio S, Linton MF
(2016) Arterioscler Thromb Vasc Biol 36: 598-607
MeSH Terms: Animals, Apoptosis, Atherosclerosis, Cell Survival, Cells, Cultured, Diet, Western, Disease Models, Animal, Female, I-kappa B Kinase, Inflammation Mediators, Liver, Liver Transplantation, Macrophages, Peritoneal, Male, Mechanistic Target of Rapamycin Complex 2, Mice, Inbred C57BL, Mice, Knockout, Multiprotein Complexes, Phosphorylation, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Receptors, LDL, Signal Transduction, TOR Serine-Threonine Kinases, Time Factors
Added February 22, 2016
0 Communities
2 Members
0 Resources
25 MeSH Terms