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Cell-programmed nutrient partitioning in the tumour microenvironment.
Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, Todd VM, Huffstater T, Abraham A, O'Neil RT, Wilson MH, Xin F, Tantawy MN, Merryman WD, Johnson RW, Williams CS, Mason EF, Mason FM, Beckermann KE, Vander Heiden MG, Manning HC, Rathmell JC, Rathmell WK
(2021) Nature 593: 282-288
MeSH Terms: Animals, Carcinoma, Renal Cell, Cell Line, Tumor, Female, Glucose, Glutamine, Humans, Lipid Metabolism, Male, Mechanistic Target of Rapamycin Complex 1, Mice, Myeloid Cells, Neoplasms, Nutrients, Tumor Microenvironment
Added April 20, 2021
0 Communities
2 Members
0 Resources
15 MeSH Terms
Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity.
Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S, Cook R, Boothby M, Chen J
(2020) JCI Insight 5:
MeSH Terms: Animals, Antineoplastic Agents, Breast Neoplasms, Carcinoma, Lewis Lung, Disease Models, Animal, Endothelium, Vascular, Everolimus, Female, Humans, Lymphocytes, Tumor-Infiltrating, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Signal Transduction
Added September 17, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis.
Rushing GV, Brockman AA, Bollig MK, Leelatian N, Mobley BC, Irish JM, Ess KC, Fu C, Ihrie RA
(2019) Life Sci Alliance 2:
MeSH Terms: Adolescent, Animals, Astrocytoma, Carcinogenesis, Cells, Cultured, Child, Child, Preschool, Disease Susceptibility, Female, Humans, Lateral Ventricles, Male, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Neural Stem Cells, Signal Transduction, Thyroid Nuclear Factor 1, Tuberous Sclerosis
Added March 27, 2019
2 Communities
2 Members
0 Resources
19 MeSH Terms
B Cell-Intrinsic mTORC1 Promotes Germinal Center-Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity.
Raybuck AL, Cho SH, Li J, Rogers MC, Lee K, Williams CL, Shlomchik M, Thomas JW, Chen J, Williams JV, Boothby MR
(2018) J Immunol 200: 2627-2639
MeSH Terms: Animals, B-Lymphocytes, Cell Differentiation, Gene Expression, Germinal Center, Immunity, Humoral, Immunoglobulin G, Immunologic Memory, Lymphocyte Activation, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Mutation, Plasma Cells, Proto-Oncogene Proteins c-bcl-6, Signal Transduction, Transcription Factors
Added March 14, 2018
1 Communities
2 Members
0 Resources
17 MeSH Terms
Cardiac natriuretic peptides promote adipose 'browning' through mTOR complex-1.
Liu D, Ceddia RP, Collins S
(2018) Mol Metab 9: 192-198
MeSH Terms: Adipose Tissue, Brown, Animals, Atrial Natriuretic Factor, Cells, Cultured, Cyclic GMP-Dependent Protein Kinases, Female, HEK293 Cells, Humans, Male, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Mitochondria, Signal Transduction, Uncoupling Protein 1
Added September 25, 2018
0 Communities
2 Members
0 Resources
15 MeSH Terms
Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination.
Grier MD, West KL, Kelm ND, Fu C, Does MD, Parker B, McBrier E, Lagrange AH, Ess KC, Carson RP
(2017) PLoS One 12: e0188417
MeSH Terms: Animals, Cell Differentiation, Cell Proliferation, Central Nervous System, Gene Expression Regulation, Developmental, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Knockout, Myelin Sheath, Oligodendrocyte Precursor Cells, Rapamycin-Insensitive Companion of mTOR Protein, Signal Transduction, White Matter
Added March 14, 2018
0 Communities
2 Members
0 Resources
14 MeSH Terms
Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.
Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E
(2017) J Clin Invest 127: 4379-4393
MeSH Terms: Animals, Glucagon, Glucagon-Secreting Cells, Hepatocyte Nuclear Factor 3-beta, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Knockout, Regulatory-Associated Protein of mTOR, Signal Transduction
Added September 21, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
Second messenger signaling mechanisms of the brown adipocyte thermogenic program: an integrative perspective.
Shi F, Collins S
(2017) Horm Mol Biol Clin Investig 31:
MeSH Terms: Adipocytes, Beige, Adipocytes, Brown, Animals, Cyclic AMP-Dependent Protein Kinases, Cyclic GMP-Dependent Protein Kinases, Energy Metabolism, Gene Expression Regulation, Humans, Intracellular Space, Mechanistic Target of Rapamycin Complex 1, MicroRNAs, Natriuretic Agents, RNA, Long Noncoding, Receptors, Adrenergic, beta, Second Messenger Systems, Signal Transduction, Thermogenesis, Uncoupling Protein 1
Added September 26, 2018
0 Communities
2 Members
0 Resources
MeSH Terms
Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.
Sinagoga KL, Stone WJ, Schiesser JV, Schweitzer JI, Sampson L, Zheng Y, Wells JM
(2017) Development 144: 2402-2414
MeSH Terms: Animals, Animals, Newborn, Cell Aggregation, Islets of Langerhans, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Mice, Models, Biological, Morphogenesis, Multiprotein Complexes, Mutation, Signal Transduction, TOR Serine-Threonine Kinases
Added February 6, 2018
0 Communities
1 Members
0 Resources
13 MeSH Terms
mTORC1 and mTORC2 in cancer and the tumor microenvironment.
Kim LC, Cook RS, Chen J
(2017) Oncogene 36: 2191-2201
MeSH Terms: Animals, Humans, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Multiprotein Complexes, Neoplasms, TOR Serine-Threonine Kinases, Tumor Microenvironment
Added March 29, 2017
1 Communities
2 Members
0 Resources
8 MeSH Terms