Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34(+) cells of juvenile myelomonocytic leukemia.
Nakazawa Y, Matsuda K, Kurata T, Sueki A, Tanaka M, Sakashita K, Imai C, Wilson MH, Koike K
(2016) J Hematol Oncol 9
: 27MeSH Terms: Antigens, CD34, Cell Line, Tumor, Cell Proliferation, Cells, Cultured, Coculture Techniques, Flow Cytometry, Humans, Immunotherapy, Adoptive, K562 Cells, Leukemia, Myelomonocytic, Juvenile, Ligands, Mutation, Receptors, Antigen, T-Cell, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Recombinant Fusion Proteins, Stem Cell Factor, T-Lymphocytes, ThrombopoietinAdded September 11, 2017
18 MeSH Terms
Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells.
Parekh VV, Wu L, Olivares-Villagómez D, Wilson KT, Van Kaer L
(2013) J Immunol 190
: 1948-60MeSH Terms: Adoptive Transfer, Animals, Antigen Presentation, Autoimmunity, Cell Communication, Cell Movement, Cell Proliferation, Central Nervous System, Encephalomyelitis, Autoimmune, Experimental, Female, Galactosylceramides, Granulocyte-Macrophage Colony-Stimulating Factor, Interferon-gamma, Interleukin-4, Mice, Mice, Transgenic, Myeloid Cells, Natural Killer T-Cells, Nitric Oxide Synthase Type II, Spleen, Transplantation Chimera, Whole-Body IrradiationAdded March 5, 2014
22 MeSH Terms
CSF-1 signaling mediates recovery from acute kidney injury.
Zhang MZ, Yao B, Yang S, Jiang L, Wang S, Fan X, Yin H, Wong K, Miyazawa T, Chen J, Chang I, Singh A, Harris RC
(2012) J Clin Invest 122
: 4519-32MeSH Terms: Acute Kidney Injury, Animals, Cell Differentiation, Cell Polarity, Cell Proliferation, Cells, Cultured, Dendritic Cells, Diphtheria Toxin, Kidney, Kidney Tubules, Proximal, Macrophage Colony-Stimulating Factor, Macrophages, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Receptor, Macrophage Colony-Stimulating Factor, Recombinant Fusion Proteins, Recovery of Function, Regeneration, Signal TransductionAdded February 26, 2014
21 MeSH Terms
Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function.
Grugan KD, McCabe FL, Kinder M, Greenplate AR, Harman BC, Ekert JE, van Rooijen N, Anderson GM, Nemeth JA, Strohl WR, Jordan RE, Brezski RJ
(2012) J Immunol 189
: 5457-66MeSH Terms: Animals, Antibodies, Neoplasm, Antigens, Neoplasm, Breast Neoplasms, CD11b Antigen, Cell Movement, Cell Proliferation, Culture Media, Conditioned, Disease Progression, Female, Humans, Immunophenotyping, Lipopolysaccharide Receptors, Macrophage Colony-Stimulating Factor, Macrophages, Mice, Mice, SCID, Neoplasm Invasiveness, Neoplasm Transplantation, Phagocytosis, Primary Cell Culture, Receptors, IgGAdded March 27, 2014
22 MeSH Terms
Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.
Serezani CH, Kane S, Collins L, Morato-Marques M, Osterholzer JJ, Peters-Golden M
(2012) J Immunol 189
: 906-15MeSH Terms: Animals, Candida albicans, Cells, Cultured, Female, Granulocyte-Macrophage Colony-Stimulating Factor, Lectins, C-Type, Leukotriene B4, Macrophages, Alveolar, Macrophages, Peritoneal, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Knockout, Proto-Oncogene Proteins, Receptors, Leukotriene B4, Trans-Activators, Transcription, GeneticAdded May 4, 2017
17 MeSH Terms
Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling.
Zaslona Z, Serezani CH, Okunishi K, Aronoff DM, Peters-Golden M
(2012) Blood 119
: 2358-67MeSH Terms: Animals, Antigens, Differentiation, CD11b Antigen, Cell Line, Tumor, Cells, Cultured, Cyclic AMP-Dependent Protein Kinases, Dinoprostone, Female, Flow Cytometry, Gene Expression, Macrophage Colony-Stimulating Factor, Macrophages, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Misoprostol, Peritonitis, Prostaglandin Antagonists, Receptor, Macrophage Colony-Stimulating Factor, Receptors, Prostaglandin E, EP2 Subtype, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Thioglycolates, XanthonesAdded May 4, 2017
25 MeSH Terms
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.
Kotecha N, Flores NJ, Irish JM, Simonds EF, Sakai DS, Archambeault S, Diaz-Flores E, Coram M, Shannon KM, Nolan GP, Loh ML
(2008) Cancer Cell 14
: 335-43MeSH Terms: Adult, Biomarkers, Tumor, Cell Proliferation, Cells, Cultured, Child, Disease Progression, Flow Cytometry, Gene Expression Regulation, Neoplastic, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Janus Kinase 2, Leukemia, Myelomonocytic, Juvenile, Myeloproliferative Disorders, Neoplasm Staging, Phosphorylation, Recurrence, STAT5 Transcription Factor, Signal Transduction, Treatment OutcomeAdded February 15, 2013
19 MeSH Terms
Use of human androgen receptor gene analysis to aid the diagnosis of JMML in female noonan syndrome patients.
Lavin VA, Hamid R, Patterson J, Alford C, Ho R, Yang E
(2008) Pediatr Blood Cancer 51
: 298-302MeSH Terms: Female, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Infant, Leukemia, Myelomonocytic, Juvenile, Mutation, Noonan Syndrome, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Receptors, AndrogenAdded March 5, 2014
9 MeSH Terms
Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis.
Tai YT, Fulciniti M, Hideshima T, Song W, Leiba M, Li XF, Rumizen M, Burger P, Morrison A, Podar K, Chauhan D, Tassone P, Richardson P, Munshi NC, Ghobrial IM, Anderson KC
(2007) Blood 110
: 1656-63MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Benzimidazoles, Bone Marrow Cells, Boronic Acids, Bortezomib, Cell Adhesion, Cell Differentiation, Cell Proliferation, Cell Survival, Cytotoxins, Dexamethasone, Dose-Response Relationship, Drug, Interleukin-6, Lenalidomide, Ligands, MAP Kinase Kinase 1, MAP Kinase Kinase 2, MAP Kinase Signaling System, Macrophage Colony-Stimulating Factor, Mice, Mice, SCID, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Multiple Myeloma, Neoplasm Transplantation, Osteoclasts, Phosphorylcholine, Pyrazines, RANK Ligand, Stromal Cells, Thalidomide, Transplantation, Heterologous, Tumor Cells, Cultured, Xenograft Model Antitumor AssaysAdded November 7, 2019
K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells.
Van Meter ME, Díaz-Flores E, Archard JA, Passegué E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun BS
(2007) Blood 109
: 3945-52MeSH Terms: Animals, Cell Proliferation, Extracellular Signal-Regulated MAP Kinases, Granulocyte-Macrophage Colony-Stimulating Factor, Hematopoietic Stem Cells, Mice, Mice, Transgenic, Myeloproliferative Disorders, Neoplastic Stem Cells, Point Mutation, Proto-Oncogene Proteins p21(ras), Ribosomal Protein S6 Kinases, STAT5 Transcription Factor, Signal TransductionAdded February 15, 2013
14 MeSH Terms