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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 18

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CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation.
Beckermann KE, Hongo R, Ye X, Young K, Carbonell K, Healey DCC, Siska PJ, Barone S, Roe CE, Smith CC, Vincent BG, Mason FM, Irish JM, Rathmell WK, Rathmell JC
(2020) JCI Insight 5:
MeSH Terms: CD28 Antigens, CD8-Positive T-Lymphocytes, Carcinoma, Renal Cell, Gene Expression Regulation, Glucose, Glycolysis, Humans, Interleukin-7, Kidney Neoplasms, Lymphocytes, Tumor-Infiltrating, Mitochondria, Nephritis, Single-Cell Analysis, Tumor Microenvironment
Added August 25, 2020
3 Communities
1 Members
0 Resources
14 MeSH Terms
Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity.
Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S, Cook R, Boothby M, Chen J
(2020) JCI Insight 5:
MeSH Terms: Animals, Antineoplastic Agents, Breast Neoplasms, Carcinoma, Lewis Lung, Disease Models, Animal, Endothelium, Vascular, Everolimus, Female, Humans, Lymphocytes, Tumor-Infiltrating, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Signal Transduction
Added September 17, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
Improved Prognosis and Increased Tumor-Infiltrating Lymphocytes in Patients Who Have SCLC With Neurologic Paraneoplastic Syndromes.
Iams WT, Shiuan E, Meador CB, Roth M, Bordeaux J, Vaupel C, Boyd KL, Summitt IB, Wang LL, Schneider JT, Warner JL, Zhao Z, Lovly CM
(2019) J Thorac Oncol 14: 1970-1981
MeSH Terms: Aged, B7-H1 Antigen, Biomarkers, Tumor, Female, Humans, Lung Neoplasms, Lymphocytes, Tumor-Infiltrating, Male, Middle Aged, Paraneoplastic Syndromes, Nervous System, Prognosis, Retrospective Studies, Small Cell Lung Carcinoma, Survival Rate, Tumor Microenvironment
Added September 10, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Papillary thyroid carcinoma behavior: clues in the tumor microenvironment.
Bergdorf K, Ferguson DC, Mehrad M, Ely K, Stricker T, Weiss VL
(2019) Endocr Relat Cancer 26: 601-614
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Female, Follow-Up Studies, Humans, Lymphocytes, Tumor-Infiltrating, Male, Middle Aged, Mutation, Prognosis, Thyroid Cancer, Papillary, Thyroid Neoplasms, Tumor Microenvironment, Young Adult
Added April 15, 2019
0 Communities
1 Members
0 Resources
17 MeSH Terms
Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8 T cells.
Gemta LF, Siska PJ, Nelson ME, Gao X, Liu X, Locasale JW, Yagita H, Slingluff CL, Hoehn KL, Rathmell JC, Bullock TNJ
(2019) Sci Immunol 4:
MeSH Terms: Animals, Antineoplastic Agents, Immunological, CD8-Positive T-Lymphocytes, Cell Line, Tumor, Glucose, Glucose Transporter Type 1, Glycolysis, Hepatitis A Virus Cellular Receptor 2, Humans, Immunoglobulin G, Immunotherapy, Adoptive, Lymphocytes, Tumor-Infiltrating, Melanoma, Mice, Inbred C57BL, Phosphopyruvate Hydratase, Programmed Cell Death 1 Receptor
Added March 30, 2020
0 Communities
1 Members
0 Resources
16 MeSH Terms
Association of tumor-infiltrating lymphocytes with distant disease-free survival in the ShortHER randomized adjuvant trial for patients with early HER2+ breast cancer.
Dieci MV, Conte P, Bisagni G, Brandes AA, Frassoldati A, Cavanna L, Musolino A, Giotta F, Rimanti A, Garrone O, Bertone E, Cagossi K, Sarti S, Ferro A, Piacentini F, Maiorana A, Orvieto E, Sanders M, Miglietta F, Balduzzi S, D'Amico R, Guarneri V
(2019) Ann Oncol 30: 418-423
MeSH Terms: Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Chemotherapy, Adjuvant, Disease-Free Survival, Drug-Related Side Effects and Adverse Reactions, Female, Humans, Kaplan-Meier Estimate, Lymphocytes, Tumor-Infiltrating, Middle Aged, Neoplasm Recurrence, Local, Receptor, ErbB-2, Trastuzumab, Treatment Outcome
Added April 2, 2019
0 Communities
1 Members
0 Resources
16 MeSH Terms
Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers.
Elion DL, Jacobson ME, Hicks DJ, Rahman B, Sanchez V, Gonzales-Ericsson PI, Fedorova O, Pyle AM, Wilson JT, Cook RS
(2018) Cancer Res 78: 6183-6195
MeSH Terms: Animals, Apoptosis, Breast Neoplasms, Cell Line, Tumor, Cytokines, DEAD Box Protein 58, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Immunity, Innate, Immunotherapy, Lymphocytes, Tumor-Infiltrating, MCF-7 Cells, Mice, Mice, Inbred BALB C, Mice, Nude, Nanoparticles, Neoplasm Metastasis, Neoplasms, Pyroptosis, Receptors, Immunologic, Signal Transduction, Tumor Microenvironment
Added April 15, 2019
0 Communities
1 Members
0 Resources
24 MeSH Terms
Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images.
Saltz J, Gupta R, Hou L, Kurc T, Singh P, Nguyen V, Samaras D, Shroyer KR, Zhao T, Batiste R, Van Arnam J, Cancer Genome Atlas Research Network, Shmulevich I, Rao AUK, Lazar AJ, Sharma A, Thorsson V
(2018) Cell Rep 23: 181-193.e7
MeSH Terms: Deep Learning, Humans, Image Interpretation, Computer-Assisted, Lymphocytes, Tumor-Infiltrating, Neoplasms
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer.
Dushyanthen S, Teo ZL, Caramia F, Savas P, Mintoff CP, Virassamy B, Henderson MA, Luen SJ, Mansour M, Kershaw MH, Trapani JA, Neeson PJ, Salgado R, McArthur GA, Balko JM, Beavis PA, Darcy PK, Loi S
(2017) Nat Commun 8: 606
MeSH Terms: 4-1BB Ligand, Animals, Breast Neoplasms, Cell Line, Tumor, Cell Proliferation, Female, Humans, Immunotherapy, Lymphocytes, Tumor-Infiltrating, MAP Kinase Kinase 1, MAP Kinase Kinase 2, MAP Kinase Signaling System, Mammary Neoplasms, Animal, Mice, OX40 Ligand, Protein Kinase Inhibitors, Pyridones, Pyrimidinones, T-Lymphocyte Subsets, T-Lymphocytes, Triple Negative Breast Neoplasms
Added March 14, 2018
0 Communities
1 Members
0 Resources
21 MeSH Terms
A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Mutations, TNBC Subtype, AR Status, and Ki67.
Jovanović B, Mayer IA, Mayer EL, Abramson VG, Bardia A, Sanders ME, Kuba MG, Estrada MV, Beeler JS, Shaver TM, Johnson KC, Sanchez V, Rosenbluth JM, Dillon PM, Forero-Torres A, Chang JC, Meszoely IM, Grau AM, Lehmann BD, Shyr Y, Sheng Q, Chen SC, Arteaga CL, Pietenpol JA
(2017) Clin Cancer Res 23: 4035-4045
MeSH Terms: Adult, Cisplatin, DNA Damage, Drug-Related Side Effects and Adverse Reactions, Everolimus, Female, High-Throughput Nucleotide Sequencing, Humans, Ki-67 Antigen, Lymphocytes, Tumor-Infiltrating, Middle Aged, Mutation, Neoplasm Staging, Paclitaxel, Receptors, Androgen, Treatment Outcome, Triple Negative Breast Neoplasms
Added April 9, 2017
1 Communities
2 Members
0 Resources
17 MeSH Terms