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Single-Cell Analyses Confirm the Critical Role of LRP6 for Wnt Signaling in APC-Deficient Cells.
Cabel CR, Alizadeh E, Robbins DJ, Ahmed Y, Lee E, Thorne CA
(2019) Dev Cell 49: 827-828
MeSH Terms: Clathrin, Low Density Lipoprotein Receptor-Related Protein-6, Single-Cell Analysis, Wnt Signaling Pathway
Added July 23, 2019
0 Communities
1 Members
0 Resources
4 MeSH Terms
Wnt pathway activation by ADP-ribosylation.
Yang E, Tacchelly-Benites O, Wang Z, Randall MP, Tian A, Benchabane H, Freemantle S, Pikielny C, Tolwinski NS, Lee E, Ahmed Y
(2016) Nat Commun 7: 11430
MeSH Terms: Adenosine Diphosphate Ribose, Amino Acid Sequence, Animals, Animals, Genetically Modified, Axin Protein, Cell Line, Tumor, Drosophila Proteins, Drosophila melanogaster, Embryo, Nonmammalian, Gene Expression Regulation, Developmental, HEK293 Cells, Humans, Low Density Lipoprotein Receptor-Related Protein-6, Lymphocytes, Molecular Sequence Data, Proteolysis, Sequence Alignment, Tankyrases, Wnt Signaling Pathway, Wnt3A Protein, beta Catenin
Added February 13, 2017
0 Communities
1 Members
0 Resources
21 MeSH Terms
Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer.
Rasmussen NR, Wright TM, Brooks SA, Hacker KE, Debebe Z, Sendor AB, Walker MP, Major MB, Green J, Wahl GM, Rathmell WK
(2013) J Biol Chem 288: 26301-26310
MeSH Terms: Axin Protein, Carcinoma, Renal Cell, Cell Line, Tumor, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Kidney Neoplasms, Low Density Lipoprotein Receptor-Related Protein-6, Neoplasm Proteins, Receptor Tyrosine Kinase-like Orphan Receptors, Wnt Signaling Pathway, Wnt3A Protein, beta Catenin
Added October 17, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
A p120-catenin-CK1epsilon complex regulates Wnt signaling.
Casagolda D, Del Valle-Pérez B, Valls G, Lugilde E, Vinyoles M, Casado-Vela J, Solanas G, Batlle E, Reynolds AB, Casal JI, de Herreros AG, Duñach M
(2010) J Cell Sci 123: 2621-31
MeSH Terms: Adaptor Proteins, Signal Transducing, Cadherins, Casein Kinase 1 epsilon, Catenins, Cell Line, Tumor, Dishevelled Proteins, Humans, Immunoprecipitation, LDL-Receptor Related Proteins, Low Density Lipoprotein Receptor-Related Protein-5, Low Density Lipoprotein Receptor-Related Protein-6, Mass Spectrometry, Phosphoproteins, Phosphorylation, Protein Binding, Signal Transduction, Wnt Proteins
Added March 28, 2014
1 Communities
1 Members
0 Resources
17 MeSH Terms
Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.
Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E
(2010) Sci Signal 3: ra37
MeSH Terms: Animals, Drosophila melanogaster, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Glycogen Synthase Kinase 3, HeLa Cells, Humans, LDL-Receptor Related Proteins, Low Density Lipoprotein Receptor-Related Protein-6, Signal Transduction, Transcription, Genetic, Wnt Proteins, Xenopus laevis, beta Catenin, beta-Adrenergic Receptor Kinases
Added December 10, 2013
0 Communities
3 Members
0 Resources
15 MeSH Terms
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin.
Cselenyi CS, Jernigan KK, Tahinci E, Thorne CA, Lee LA, Lee E
(2008) Proc Natl Acad Sci U S A 105: 8032-7
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Axin Protein, Cattle, Cell Extracts, Dishevelled Proteins, Embryo, Nonmammalian, Glycogen Synthase Kinase 3, Intracellular Space, Low Density Lipoprotein Receptor-Related Protein-6, Mice, Ovum, Phosphoproteins, Phosphorylation, Proteasome Endopeptidase Complex, Protein Processing, Post-Translational, Protein Structure, Tertiary, Receptors, LDL, Recombinant Proteins, Repressor Proteins, Signal Transduction, Thermodynamics, Ubiquitin, Wnt Proteins, Xenopus, Xenopus Proteins, beta Catenin
Added March 5, 2014
0 Communities
2 Members
0 Resources
27 MeSH Terms
Lrp6 is required for convergent extension during Xenopus gastrulation.
Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E
(2007) Development 134: 4095-106
MeSH Terms: Amino Acid Sequence, Animals, Animals, Genetically Modified, Body Patterning, Cell Polarity, Cells, Cultured, Embryo, Nonmammalian, Gastrulation, Gene Expression Regulation, Developmental, Humans, Low Density Lipoprotein Receptor-Related Protein-6, Mesoderm, Models, Biological, Molecular Sequence Data, Receptors, LDL, Sequence Homology, Amino Acid, Signal Transduction, Tissue Distribution, Wnt Proteins, Xenopus, beta Catenin
Added August 12, 2010
1 Communities
4 Members
0 Resources
21 MeSH Terms