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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 22

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Biased M receptor-positive allosteric modulators reveal role of phospholipase D in M-dependent rodent cortical plasticity.
Moran SP, Xiang Z, Doyle CA, Maksymetz J, Lv X, Faltin S, Fisher NM, Niswender CM, Rook JM, Lindsley CW, Conn PJ
(2019) Sci Signal 12:
MeSH Terms: Allosteric Site, Animals, CHO Cells, Calcium, Cerebral Cortex, Cognition, Cricetinae, Cricetulus, Electrophysiology, Female, Humans, Long-Term Synaptic Depression, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Neuronal Plasticity, Phospholipase D, Prefrontal Cortex, Receptor, Muscarinic M1, Signal Transduction, Type C Phospholipases
Added March 3, 2020
0 Communities
2 Members
0 Resources
22 MeSH Terms
Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5.
Stansley BJ, Fisher NM, Gogliotti RG, Lindsley CW, Conn PJ, Niswender CM
(2018) Cereb Cortex 28: 4291-4304
MeSH Terms: Animals, Extinction, Psychological, Fear, Hippocampus, Long-Term Potentiation, Long-Term Synaptic Depression, Male, Methyl-CpG-Binding Protein 2, Mice, Inbred C57BL, Mice, Transgenic, Receptor, Cannabinoid, CB1, Receptors, Kainic Acid, Receptors, N-Methyl-D-Aspartate
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M PAM VU6004256.
Grannan MD, Mielnik CA, Moran SP, Gould RW, Ball J, Lu Z, Bubser M, Ramsey AJ, Abe M, Cho HP, Nance KD, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW, Jones CK
(2016) ACS Chem Neurosci 7: 1706-1716
MeSH Terms: Action Potentials, Animals, Cholinergic Agents, Cognition Disorders, Conditioning, Psychological, Disease Models, Animal, Drug Evaluation, Preclinical, Fear, Gene Knockdown Techniques, Heterocyclic Compounds, 4 or More Rings, Long-Term Synaptic Depression, Male, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Nerve Tissue Proteins, Nootropic Agents, Prefrontal Cortex, Pyramidal Cells, Receptors, N-Methyl-D-Aspartate, Recognition, Psychology, Tissue Culture Techniques
Added April 6, 2017
0 Communities
3 Members
0 Resources
23 MeSH Terms
Structural basis for integration of GluD receptors within synaptic organizer complexes.
Elegheert J, Kakegawa W, Clay JE, Shanks NF, Behiels E, Matsuda K, Kohda K, Miura E, Rossmann M, Mitakidis N, Motohashi J, Chang VT, Siebold C, Greger IH, Nakagawa T, Yuzaki M, Aricescu AR
(2016) Science 353: 295-9
MeSH Terms: Animals, Ligands, Long-Term Synaptic Depression, Mice, Nerve Tissue Proteins, Neurogenesis, Protein Multimerization, Protein Precursors, Protein Structure, Tertiary, Purkinje Cells, Receptors, Glutamate, Signal Transduction, Synapses
Added April 6, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.
Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ
(2015) Neuron 88: 762-73
MeSH Terms: Allosteric Regulation, Animals, Cerebral Cortex, Disease Models, Animal, Dopamine Agents, Dyskinesia, Drug-Induced, Glutamic Acid, Levodopa, Long-Term Potentiation, Long-Term Synaptic Depression, Macaca mulatta, Mice, Mice, Transgenic, Neostriatum, Neuronal Plasticity, Neurons, Parkinsonian Disorders, RGS Proteins, Receptor, Muscarinic M4, Signal Transduction
Added February 18, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Chronic intermittent alcohol disrupts the GluN2B-associated proteome and specifically regulates group I mGlu receptor-dependent long-term depression.
Wills TA, Baucum AJ, Holleran KM, Chen Y, Pasek JG, Delpire E, Tabb DL, Colbran RJ, Winder DG
(2017) Addict Biol 22: 275-290
MeSH Terms: Animals, Central Nervous System Depressants, Cytoskeletal Proteins, Ethanol, Hippocampus, Homer Scaffolding Proteins, Long-Term Synaptic Depression, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Nerve Tissue Proteins, Proteome, Receptors, Metabotropic Glutamate, Receptors, N-Methyl-D-Aspartate, Signal Transduction
Added February 15, 2016
0 Communities
3 Members
0 Resources
16 MeSH Terms
Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model.
Ghoshal A, Rook JM, Dickerson JW, Roop GN, Morrison RD, Jalan-Sakrikar N, Lamsal A, Noetzel MJ, Poslusney MS, Wood MR, Melancon BJ, Stauffer SR, Xiang Z, Daniels JS, Niswender CM, Jones CK, Lindsley CW, Conn PJ
(2016) Neuropsychopharmacology 41: 598-610
MeSH Terms: Animals, Antipsychotic Agents, Cognition, Disease Models, Animal, Long-Term Synaptic Depression, Male, Mice, Inbred C57BL, Mice, Knockout, Patch-Clamp Techniques, Phencyclidine, Pyridines, Pyrroles, Receptor, Muscarinic M1, Schizophrenia, Schizophrenic Psychology, Social Behavior
Added February 18, 2016
0 Communities
4 Members
0 Resources
16 MeSH Terms
Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.
Walker AG, Wenthur CJ, Xiang Z, Rook JM, Emmitte KA, Niswender CM, Lindsley CW, Conn PJ
(2015) Proc Natl Acad Sci U S A 112: 1196-201
MeSH Terms: Animals, Behavior, Animal, Cognition, Fear, HEK293 Cells, Humans, Long-Term Synaptic Depression, Mice, Mice, Inbred ICR, Mice, Knockout, Prefrontal Cortex, Rats, Receptors, Metabotropic Glutamate
Added January 20, 2015
0 Communities
3 Members
0 Resources
13 MeSH Terms
Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning.
Xu J, Zhu Y, Kraniotis S, He Q, Marshall JJ, Nomura T, Stauffer SR, Lindsley CW, Conn PJ, Contractor A
(2013) Learn Mem 20: 438-45
MeSH Terms: Adaptation, Psychological, Animals, Extinction, Psychological, Hippocampus, Long-Term Synaptic Depression, Male, Maze Learning, Mice, Mice, Inbred C57BL, Mice, Knockout, Oxadiazoles, Piperidines, Receptor, Metabotropic Glutamate 5
Added February 19, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
High times for low-frequency stimulation as endocannabinoids engage in hippocampal long-term depression.
Patel S
(2012) Neuropsychopharmacology 37: 583-5
MeSH Terms: Animals, Cannabinoid Receptor Modulators, Endocannabinoids, Hippocampus, Long-Term Synaptic Depression, Receptor, Metabotropic Glutamate 5, Receptors, Metabotropic Glutamate, Receptors, N-Methyl-D-Aspartate
Added January 20, 2015
0 Communities
1 Members
0 Resources
8 MeSH Terms