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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 60

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Androgenic effects on ventricular repolarization: A translational study from the international pharmacovigilance database to iPSC-cardiomyocytes.
Salem JE, Yang T, Moslehi JJ, Waintraub X, Gandjbakhch E, Bachelot A, Hidden-Lucet F, Hulot JS, Knollmann BC, Lebrun-Vignes B, Funck-Brentano C, Glazer AM, Roden DM
(2021) Ann Endocrinol (Paris) 82: 132-133
MeSH Terms: Androgens, Cell Differentiation, Cells, Cultured, Databases, Factual, Death, Sudden, Cardiac, Dihydrotestosterone, Electrophysiological Phenomena, Eunuchism, Heart Ventricles, Humans, Induced Pluripotent Stem Cells, Internationality, Long QT Syndrome, Male, Membrane Potentials, Myocytes, Cardiac, Pharmacovigilance, Torsades de Pointes, Translational Research, Biomedical, Ventricular Function
Added March 24, 2020
0 Communities
2 Members
0 Resources
20 MeSH Terms
Calmodulin Mutations Associated with Heart Arrhythmia: A Status Report.
Chazin WJ, Johnson CN
(2020) Int J Mol Sci 21:
MeSH Terms: Arrhythmias, Cardiac, Calcium Signaling, Calmodulin, Humans, Ion Channels, Long QT Syndrome, Myocytes, Cardiac, Ryanodine Receptor Calcium Release Channel, Tachycardia, Ventricular
Added March 11, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition.
Roberts JD, Asaki SY, Mazzanti A, Bos JM, Tuleta I, Muir AR, Crotti L, Krahn AD, Kutyifa V, Shoemaker MB, Johnsrude CL, Aiba T, Marcondes L, Baban A, Udupa S, Dechert B, Fischbach P, Knight LM, Vittinghoff E, Kukavica D, Stallmeyer B, Giudicessi JR, Spazzolini C, Shimamoto K, Tadros R, Cadrin-Tourigny J, Duff HJ, Simpson CS, Roston TM, Wijeyeratne YD, El Hajjaji I, Yousif MD, Gula LJ, Leong-Sit P, Chavali N, Landstrom AP, Marcus GM, Dittmann S, Wilde AAM, Behr ER, Tfelt-Hansen J, Scheinman MM, Perez MV, Kaski JP, Gow RM, Drago F, Aziz PF, Abrams DJ, Gollob MH, Skinner JR, Shimizu W, Kaufman ES, Roden DM, Zareba W, Schwartz PJ, Schulze-Bahr E, Etheridge SP, Priori SG, Ackerman MJ
(2020) Circulation 141: 429-439
MeSH Terms: Adolescent, Adult, Death, Sudden, Cardiac, Electric Countershock, Electrocardiography, Female, Heart Arrest, Humans, Long QT Syndrome, Male, Middle Aged, Penetrance, Potassium Channels, Voltage-Gated, Registries
Added March 24, 2020
0 Communities
1 Members
0 Resources
14 MeSH Terms
Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes.
Salem JE, Yang T, Moslehi JJ, Waintraub X, Gandjbakhch E, Bachelot A, Hidden-Lucet F, Hulot JS, Knollmann BC, Lebrun-Vignes B, Funck-Brentano C, Glazer AM, Roden DM
(2019) Circulation 140: 1070-1080
MeSH Terms: Androgens, Antineoplastic Agents, Benzamides, Cell Differentiation, Cells, Cultured, Databases, Factual, Humans, Hypogonadism, Induced Pluripotent Stem Cells, International Cooperation, Long QT Syndrome, Male, Myocytes, Cardiac, Nitriles, Pharmacovigilance, Phenylthiohydantoin, Risk, Torsades de Pointes, Translational Research, Biomedical
Added November 12, 2019
0 Communities
2 Members
0 Resources
19 MeSH Terms
Patient-independent human induced pluripotent stem cell model: A new tool for rapid determination of genetic variant pathogenicity in long QT syndrome.
Chavali NV, Kryshtal DO, Parikh SS, Wang L, Glazer AM, Blackwell DJ, Kroncke BM, Shoemaker MB, Knollmann BC
(2019) Heart Rhythm 16: 1686-1695
MeSH Terms: Action Potentials, Calcium Channels, L-Type, Child, Clustered Regularly Interspaced Short Palindromic Repeats, Female, Gene Editing, Genetic Testing, Genetic Variation, Humans, Induced Pluripotent Stem Cells, Long QT Syndrome, Pedigree, Phenotype
Added March 4, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
A current understanding of drug-induced QT prolongation and its implications for anticancer therapy.
Roden DM
(2019) Cardiovasc Res 115: 895-903
MeSH Terms: Action Potentials, Animals, Antineoplastic Agents, Genetic Predisposition to Disease, Heart Conduction System, Heart Rate, Humans, Long QT Syndrome, Membrane Transport Proteins, Molecular Targeted Therapy, Prognosis, Risk Assessment, Risk Factors
Added March 24, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Multiple mechanisms underlie increased cardiac late sodium current.
Kroncke BM, Yang T, Roden DM
(2019) Heart Rhythm 16: 1091-1097
MeSH Terms: Action Potentials, Animals, CHO Cells, Cardiac Conduction System Disease, Cricetinae, Cricetulus, Genotype, Humans, Induced Pluripotent Stem Cells, Kidney, Long QT Syndrome, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Phenotype, Phosphatidylinositol 3-Kinases
Added March 26, 2019
0 Communities
3 Members
0 Resources
15 MeSH Terms
Increased long QT and torsade de pointes reporting on tamoxifen compared with aromatase inhibitors.
Grouthier V, Lebrun-Vignes B, Glazer AM, Touraine P, Funck-Brentano C, Pariente A, Courtillot C, Bachelot A, Roden DM, Moslehi JJ, Salem JE
(2018) Heart 104: 1859-1863
MeSH Terms: Action Potentials, Adolescent, Adult, Adverse Drug Reaction Reporting Systems, Aged, Aged, 80 and over, Aromatase Inhibitors, Cardiotoxicity, Databases, Factual, Europe, Female, Heart Conduction System, Heart Rate, Humans, Long QT Syndrome, Middle Aged, Prognosis, Risk Assessment, Risk Factors, Selective Estrogen Receptor Modulators, Tamoxifen, Torsades de Pointes, Young Adult
Added October 1, 2018
0 Communities
2 Members
0 Resources
23 MeSH Terms
Arrhythmia genetics: Not dark and lite, but 50 shades of gray.
Roden DM, Glazer AM, Kroncke B
(2018) Heart Rhythm 15: 1231-1232
MeSH Terms: Arrhythmias, Cardiac, Humans, Long QT Syndrome, Phenotype, Potassium Channels, Voltage-Gated
Added March 26, 2019
0 Communities
3 Members
0 Resources
MeSH Terms
Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations.
Huang H, Kuenze G, Smith JA, Taylor KC, Duran AM, Hadziselimovic A, Meiler J, Vanoye CG, George AL, Sanders CR
(2018) Sci Adv 4: eaar2631
MeSH Terms: Cell Membrane, HEK293 Cells, Humans, KCNQ1 Potassium Channel, Leupeptins, Long QT Syndrome, Loss of Function Mutation, Magnetic Resonance Spectroscopy, Mutant Proteins, Mutation, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Protein Domains, Protein Folding, Protein Structure, Secondary, Proteolysis
Added March 14, 2018
0 Communities
3 Members
0 Resources
16 MeSH Terms