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Apolipoprotein L1 and Chronic Kidney Disease Risk in Young Potential Living Kidney Donors.
Locke JE, Sawinski D, Reed RD, Shelton B, MacLennan PA, Kumar V, Mehta S, Mannon RB, Gaston R, Julian BA, Carr JJ, Terry JG, Kilgore M, Massie AB, Segev DL, Lewis CE
(2018) Ann Surg 267: 1161-1168
MeSH Terms: Adolescent, Adult, African Americans, Apolipoprotein L1, European Continental Ancestry Group, Female, Follow-Up Studies, Genotype, Humans, Kidney Transplantation, Living Donors, Male, Renal Insufficiency, Chronic, Risk Assessment, Young Adult
Show Abstract · Added September 11, 2017
OBJECTIVE - The aim of this study was to develop a novel chronic kidney disease (CKD) risk prediction tool for young potential living kidney donors.
SUMMARY OF BACKGROUND DATA - Living kidney donor selection practices have evolved from examining individual risk factors to a risk calculator incorporating multiple characteristics. Owing to limited long-term data and lack of genetic information, current risk tools lack precision among young potential living kidney donors, particularly African Americans (AAs).
METHODS - We identified a cohort of young adults (18-30 years) with no absolute contraindication to kidney donation from the longitudinal cohort study Coronary Artery Risk Development in Young Adults. Risk associations for CKD (estimated glomerular filtration rate <60 mL/min/1.73 m) were identified and assigned weighted points to calculate risk scores.
RESULTS - A total of 3438 healthy adults were identified [mean age 24.8 years; 48.3% AA; median follow-up 24.9 years (interquartile range: 24.5-25.2)]. For 18-year olds, 25-year projected CKD risk varied by ethnicity and sex even without baseline clinical and genetic abnormalities; risk was 0.30% for European American (EA) women, 0.52% for EA men, 0.52% for AA women, 0.90% for AA men. Among 18-year-old AAs with apolipoprotein L1 gene (APOL1) renal-risk variants without baseline abnormalities, 25-year risk significantly increased: 1.46% for women and 2.53% for men; among those with 2 APOL1 renal-risk variants and baseline abnormalities, 25-year risk was higher: 2.53% to 6.23% for women and 4.35% to 10.58% for men.
CONCLUSIONS - Young AAs were at highest risk for CKD, and APOL1 renal-risk variants drove some of this risk. Understanding the genetic profile of young AA potential living kidney donors in the context of baseline health characteristics may help to inform candidate selection and counseling.
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15 MeSH Terms
Living donor liver transplantation from a heterozygous parent for classical maple syrup urine disease.
Kadohisa M, Matsumoto S, Sawada H, Honda M, Murokawa T, Hayashida S, Ohya Y, Lee KJ, Yamamoto H, Mitsubuchi H, Endo F, Inomata Y
(2015) Pediatr Transplant 19: E66-9
MeSH Terms: Amino Acids, Branched-Chain, Fathers, Female, Heterozygote, Humans, Infant, Liver Transplantation, Living Donors, Male, Maple Syrup Urine Disease, Postoperative Period, Treatment Outcome
Show Abstract · Added March 7, 2015
MSUD is a hereditary metabolic disorder that is characterized by impaired activity of the BCKADC. Liver transplantation has been approved as a treatment for some MSUD cases in which the control of BCAAs is insufficient. Although there have been several reports about DDLT for MSUD, few LDLT cases have been reported. Because either of parents who are heterozygote of this disease usually applies to be a candidate of donor in LDLT, the impairment of BCKADC activity of graft liver should be concerned. We performed LDLT for 10 month-old girl with a left lateral segment graft from her father. BCKADC activities of the patient and her parents were measured using lysates of lymphocytes isolated from peripheral blood specimen before the transplant. As a consequence, the activity of BCKADC of father was not inferior to a normal range. The patient tolerated the operation well. Postoperative course was uneventful and mixed milk was started at 8th POD. The serum BCAAs levels have remained within normal range. It should be necessary to follow the physical growth and mental development of the recipient in the future.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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12 MeSH Terms
Development and validation of a questionnaire to assess fear of kidney failure following living donation.
Rodrigue JR, Fleishman A, Vishnevsky T, Whiting J, Vella JP, Garrison K, Moore D, Kayler L, Baliga P, Chavin KD, Karp S, Mandelbrot DA
(2014) Transpl Int 27: 570-5
MeSH Terms: Adult, Age Factors, Anxiety, Cross-Sectional Studies, Fear, Female, Humans, Incidence, Kidney Transplantation, Living Donors, Male, Middle Aged, Nephrectomy, Odds Ratio, Psychometrics, Reference Values, Renal Insufficiency, Reproducibility of Results, Risk Assessment, Self Report, Sex Factors, Stress, Psychological, Surveys and Questionnaires
Show Abstract · Added May 22, 2014
Living kidney donors (LKDs) may feel more anxious about kidney failure now that they have only one kidney and the security of a second kidney is gone. The aim of this cross-sectional study was to develop and empirically validate a self-report scale for assessing fear of kidney failure in former LKDs. Participants were 364 former LKDs within the past 10 years at five US transplant centers and 219 healthy nondonor controls recruited through Mechanical Turk who completed several questionnaires. Analyses revealed a unidimensional factor structure, excellent internal consistency (α = 0.88), and good convergent validity for the Fear of Kidney Failure questionnaire. Only 13% of former donors reported moderate to high fear of kidney failure. Nonwhite race (OR = 2.9, P = 0.01), genetic relationship with the recipient (OR = 2.46, P = 0.04), and low satisfaction with the donation experience (OR = 0.49, P = 0.002) were significant predictors of higher fear of kidney failure. We conclude that while mild anxiety about kidney failure is common, high anxiety about future renal failure among former LKDs is uncommon. The Fear of Kidney Failure questionnaire is reliable, valid, and easy to use in the clinical setting.
© 2014 Steunstichting ESOT.
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23 MeSH Terms
Health literacy of living kidney donors and kidney transplant recipients.
Dageforde LA, Petersen AW, Feurer ID, Cavanaugh KL, Harms KA, Ehrenfeld JM, Moore DE
(2014) Transplantation 98: 88-93
MeSH Terms: Adult, Chi-Square Distribution, Female, Health Knowledge, Attitudes, Practice, Health Literacy, Healthcare Disparities, Humans, Kidney Transplantation, Living Donors, Logistic Models, Male, Middle Aged, Odds Ratio, Patients, Retrospective Studies, Socioeconomic Factors, Surveys and Questionnaires, Tennessee
Show Abstract · Added March 7, 2014
BACKGROUND - Health literacy (HL) may be a mediator for known socioeconomic and racial disparities in living kidney donation.
METHODS - We evaluated the associations of patient and demographic characteristics with HL in living kidney donors (LD), living donor kidney transplant recipients (LDR), and deceased donor recipients (DDR) in a single-center retrospective review of patients undergoing kidney donation or transplantation from September 2010 to July 2012. HL and demographic data were collected. HL was assessed via the Short Literacy Survey (SLS) comprising three self-reported screening questions scored using the five-point Likert scale (low, moderate, high). Chi-square and logistic regression were used to test factors associated with lower HL.
RESULTS - The sample included 360 adults (105 LD, 103 LDR, and 152 DDR; 46±14 years; 70% white; 56% male; 14±3 years of education). HL scores were skewed (49% high, 41% moderate, and 10% low). The distribution of HL categories differed significantly among groups (P=0.019). After controlling for age, race, sex, education, and a race-education interaction term, DDR was more likely to have moderate or low HL than LDR (OR, 1.911; 95% CI, 1.096-3.332; P=0.022).
CONCLUSION - Overall, living donors had high HL. The distribution of low, moderate, and high HL differed significantly between LD, DDR, and LDR. DDR had a higher likelihood of having low HL than LDR. Screening kidney transplant candidates and donors for lower HL may identify barriers to living donation. Future interventions addressing HL may be important to increase living donation and reduce disparities.
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18 MeSH Terms
Cost saving associated with implementing a stepwise approach to HLA typing of related donors before hematopoietic SCT.
Frangoul H, Crowe D
(2014) Bone Marrow Transplant 49: 850-1
MeSH Terms: Cost Savings, Donor Selection, Hematopoietic Stem Cell Transplantation, Histocompatibility Testing, Humans, Living Donors
Added March 27, 2014
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6 MeSH Terms
Single-center experience and long-term outcomes of duct-to-duct biliary reconstruction in infantile living donor liver transplantation.
Yamamoto H, Hayashida S, Asonuma K, Honda M, Suda H, Murokawa T, Ohya Y, Lee KJ, Takeichi T, Inomata Y
(2014) Liver Transpl 20: 347-54
MeSH Terms: Anastomosis, Roux-en-Y, Bile Ducts, Body Weight, Child, Preschool, Cholangiography, Cholangitis, Cholestasis, End Stage Liver Disease, Female, Follow-Up Studies, Humans, Infant, Liver Transplantation, Living Donors, Male, Treatment Outcome
Show Abstract · Added February 11, 2015
The indications for duct-to-duct (DD) biliary reconstruction in living donor liver transplantation (LDLT) for small children are still controversial. In this study, the feasibility of DD biliary reconstruction versus Roux-en-Y (RY) biliary reconstruction was investigated in terms of long-term outcomes. Fifty-six children who consecutively underwent LDLT with a weight less than or equal to 10.0 kg were enrolled. Biliary reconstruction was performed in a DD fashion for 20 patients and in an RY fashion for 36 patients. During a minimum follow-up of 2 years, the incidence of biliary strictures was 5.0% in the DD group and 11.1% in the RY group. Cholangitis during the posttransplant period was observed in the RY group only. There were no deaths related to biliary problems. This study shows that DD reconstruction in LDLT for small children (weighing 10.0 kg or less) is a feasible option for biliary reconstruction.
© 2014 American Association for the Study of Liver Diseases.
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16 MeSH Terms
Incidence and risk factors for new-onset diabetes in living-donor liver transplant recipients.
Honda M, Asonuma K, Hayashida S, Suda H, Ohya Y, Lee KJ, Yamamoto H, Takeichi T, Inomata Y
(2013) Clin Transplant 27: 426-35
MeSH Terms: Adolescent, Adult, Aged, Cohort Studies, Diabetes Complications, Diabetes Mellitus, Female, Follow-Up Studies, Graft Rejection, Humans, Japan, Liver Diseases, Liver Transplantation, Living Donors, Male, Middle Aged, Prognosis, Risk Factors, Survivors, Young Adult
Show Abstract · Added February 11, 2015
With the increased number of long-term survivors after liver transplantation, new-onset diabetes after transplantation (NODAT) is becoming more significant in patient follow-up. However, the incidence of new-onset diabetes after living-donor liver transplantation (LDLT) has not been well elucidated. The aim of this study was to evaluate the incidence and risk factors for NODAT in adult LDLT recipients at a single center in Japan. A retrospective study was performed on 161 adult patients without diabetes who had been followed up for ≥three months after LDLT. NODAT was defined according to the 2003 American Diabetes Association/World Health Organization guidelines. The recipient-, donor-, operation-, and immunosuppression-associated risk factors for NODAT were assessed. Overall, the incidence of NODAT was 13.7% (22/161) with a mean follow-up of 49.8 months. In a multivariate analysis, the identified risk factors for NODAT were donor liver-to-spleen (L-S) ratio (hazard ratio [HR] = 0.022, 95% confidence interval [CI] = 0.001-0.500, p = 0.017), and steroid pulse therapy for acute rejection (HR = 3.320, 95% CI = 1.365-8.075, p = 0.008). In conclusion, donor L-S ratio and steroid pulse therapy for acute rejection were independent predictors for NODAT in LDLT recipients. These findings can help in screening for NODAT and applying early interventions.
© 2013 John Wiley & Sons A/S.
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20 MeSH Terms
Peritransplant gastrointestinal symptoms in familial amyloidotic polyneuropathy.
Ohya Y, Isono K, Obayashi K, Hayashida S, Lee KJ, Yamamoto H, Takeichi T, Asonuma K, Ando Y, Inomata Y
(2013) Exp Clin Transplant 11: 327-31
MeSH Terms: Adult, Amyloid Neuropathies, Familial, Body Mass Index, Catheterization, Central Venous, Female, Gastrointestinal Diseases, Hospitals, University, Humans, Japan, Length of Stay, Liver Transplantation, Living Donors, Male, Middle Aged, Nutritional Status, Nutritional Support, Recovery of Function, Retrospective Studies, Time Factors, Treatment Outcome
Show Abstract · Added February 11, 2015
OBJECTIVES - Gastrointestinal dysfunction is a common complication in familial amyloidotic polyneuropathy, and gastrointestinal symptoms are associated with a patient's nutritional status. The object of this study was to evaluate changes in peritransplant gastrointestinal symptoms and the nutritional status of familial amyloidotic polyneuropathy patients using the modified body mass index following a living-donor liver transplant.
MATERIALS AND METHODS - In a retrospective analysis, we compared 17 Japanese familial amyloidotic polyneuropathy patients who underwent living-donor liver transplant in Kumamoto University Hospital between 2000 and 2009 with a control group of 28 patients with chronic liver disease. We analyzed the peritransplant gastrointestinal symptoms, nutritional status, duration of central venous catheterization, and postoperative hospital stay. The Mann-Whitney U test and Fisher exact test were used to analyze relations between the familial amyloidotic polyneuropathy group and control group, and the Wilcoxon signed-rank test, to analyze the relation of perioperative modified body mass index, with a value for P < .05 considered statistically significant.
RESULTS - The duration of central venous catheterization and postoperative hospital stay were significantly longer in the familial amyloidotic polyneuropathy group than they were in the control group. There was no significant difference between modified body mass index preoperatively and 1 year after living-donor liver transplant. Although gastrointestinal symptoms were typically mild before living-donor liver transplant, the familial amyloidotic polyneuropathy group experienced a temporary deterioration in gastrointestinal symptoms after receiving the living-donor liver transplant but recovered after approximately 2 months.
CONCLUSIONS - Although familial amyloidotic polyneuropathy patients experienced temporary exacerbations of gastrointestinal symptoms, their nutritional status was not affected during the peritransplant period, and they generally recovered within 2 months.
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20 MeSH Terms
Getting more people TALKing about kidney transplantation.
Cavanaugh KL
(2013) Am J Kidney Dis 61: 368-70
MeSH Terms: Attitude to Health, Female, Humans, Kidney Transplantation, Living Donors, Male, Patient Education as Topic, Renal Insufficiency, Chronic, Social Work, Tissue and Organ Procurement
Added March 7, 2014
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10 MeSH Terms
A web-based application for initial screening of living kidney donors: development, implementation and evaluation.
Moore DR, Feurer ID, Zavala EY, Shaffer D, Karp S, Hoy H, Moore DE
(2013) Am J Transplant 13: 450-7
MeSH Terms: Adult, Body Mass Index, Cohort Studies, Female, Humans, Internet, Kidney Transplantation, Living Donors, Male, Middle Aged, Models, Statistical, Patient Education as Topic, Program Development, Referral and Consultation, Renal Insufficiency, Retrospective Studies, Software, Tissue and Organ Procurement
Show Abstract · Added May 22, 2014
Most centers utilize phone or written surveys to screen candidates who self-refer to be living kidney donors. To increase efficiency and reduce resource utilization, we developed a web-based application to screen kidney donor candidates. The aim of this study was to evaluate the use of this web-based application. Method and time of referral were tabulated and descriptive statistics summarized demographic characteristics. Time series analyses evaluated use over time. Between January 1, 2011 and March 31, 2012, 1200 candidates self-referred to be living kidney donors at our center. Eight hundred one candidates (67%) completed the web-based survey and 399 (33%) completed a phone survey. Thirty-nine percent of donors accessed the application on nights and weekends. Postimplementation of the web-based application, there was a statistically significant increase (p < 0.001) in the number of self-referrals via the web-based application as opposed to telephone contact. Also, there was a significant increase (p = 0.025) in the total number of self-referrals post-implementation from 61 to 116 per month. An interactive web-based application is an effective strategy for the initial screening of donor candidates. The web-based application increased the ability to interface with donors, process them efficiently and ultimately increased donor self-referral at our center.
© Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.
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18 MeSH Terms