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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 11

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Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.
Lee HH, Leake BF, Kim RB, Ho RH
(2017) Mol Pharmacol 91: 14-24
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Biological Transport, Cell Membrane, Dogs, Doxorubicin, HeLa Cells, Humans, Kinetics, Liver, Liver-Specific Organic Anion Transporter 1, Madin Darby Canine Kidney Cells, Male, Mice, Models, Biological, Mutant Proteins, Organic Anion Transporters, Organic Anion Transporters, Sodium-Independent, Organic Cation Transport Proteins, Rats, Transfection
Added November 10, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
Contribution of hepatic organic anion-transporting polypeptides to docetaxel uptake and clearance.
Lee HH, Leake BF, Teft W, Tirona RG, Kim RB, Ho RH
(2015) Mol Cancer Ther 14: 994-1003
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Antineoplastic Agents, Biological Transport, Cell Line, Tumor, Docetaxel, Humans, Liver, Liver-Specific Organic Anion Transporter 1, Male, Mice, Mice, Knockout, Organic Anion Transporters, Organic Anion Transporters, Sodium-Independent, Rats, Solute Carrier Organic Anion Transporter Family Member 1B3, Taxoids, Tubulin Modulators
Added February 25, 2015
0 Communities
2 Members
0 Resources
18 MeSH Terms
The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update.
Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M
(2014) Clin Pharmacol Ther 96: 423-8
MeSH Terms: Drug Interactions, Genotype, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Liver-Specific Organic Anion Transporter 1, Muscular Diseases, Organic Anion Transporters, Pharmacogenetics, Polymorphism, Genetic, Simvastatin
Added June 26, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Applied pharmacogenomics in cardiovascular medicine.
Weeke P, Roden DM
(2014) Annu Rev Med 65: 81-94
MeSH Terms: Adrenergic beta-Antagonists, Antihypertensive Agents, Antithrombins, Aryl Hydrocarbon Hydroxylases, Cardiovascular Diseases, Clopidogrel, Cytochrome P-450 CYP2C19, Cytochrome P-450 CYP2C9, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Liver-Specific Organic Anion Transporter 1, Organic Anion Transporters, Pharmacogenetics, Polymorphism, Single Nucleotide, Precision Medicine, Ticlopidine, Vitamin K Epoxide Reductases, Warfarin
Added March 7, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Discordant associations between SLCO1B1 521T→C and plasma levels of ritonavir-boosted protease inhibitors in AIDS clinical trials group study A5146.
Zhang X, Tierney C, Albrecht M, Demeter LM, Morse G, DiFrancesco R, Dykes C, Jiang H, Haas DW
(2013) Ther Drug Monit 35: 209-16
MeSH Terms: Acquired Immunodeficiency Syndrome, Adult, Female, Genetic Association Studies, HIV Protease Inhibitors, Humans, Linkage Disequilibrium, Liver-Specific Organic Anion Transporter 1, Male, Middle Aged, Organic Anion Transporters, Ritonavir
Added March 13, 2015
0 Communities
1 Members
0 Resources
12 MeSH Terms
The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.
Wilke RA, Ramsey LB, Johnson SG, Maxwell WD, McLeod HL, Voora D, Krauss RM, Roden DM, Feng Q, Cooper-Dehoff RM, Gong L, Klein TE, Wadelius M, Niemi M, Clinical Pharmacogenomics Implementation Consortium (CPIC)
(2012) Clin Pharmacol Ther 92: 112-7
MeSH Terms: Drug Prescriptions, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Liver-Specific Organic Anion Transporter 1, Muscular Diseases, Organic Anion Transporters, Pharmacogenetics, Polymorphism, Single Nucleotide, Precision Medicine, Risk Assessment, Risk Factors, Simvastatin
Added June 26, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Interaction of three regiospecific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity.
DeGorter MK, Ho RH, Leake BF, Tirona RG, Kim RB
(2012) Mol Pharm 9: 986-95
MeSH Terms: Amino Acids, Cholecystokinin, Liver-Specific Organic Anion Transporter 1, Mutagenesis, Site-Directed, Organic Anion Transporters, Organic Anion Transporters, Sodium-Independent, Peptide Fragments, Solute Carrier Organic Anion Transporter Family Member 1B3, Substrate Specificity
Added March 5, 2014
2 Communities
2 Members
2 Resources
9 MeSH Terms
Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics.
Katz DA, Carr R, Grimm DR, Xiong H, Holley-Shanks R, Mueller T, Leake B, Wang Q, Han L, Wang PG, Edeki T, Sahelijo L, Doan T, Allen A, Spear BB, Kim RB
(2006) Clin Pharmacol Ther 79: 186-96
MeSH Terms: Adult, Alleles, Atrasentan, Carrier Proteins, Female, Genotype, HeLa Cells, Humans, Liver-Specific Organic Anion Transporter 1, Male, Middle Aged, Organic Anion Transporters, Phenotype, Pyrrolidines, Transfection
Added March 27, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Hepatic uptake of the novel antifungal agent caspofungin.
Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB
(2005) Drug Metab Dispos 33: 676-82
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Adsorption, Animals, Antifungal Agents, Carrier Proteins, Caspofungin, Echinocandins, HeLa Cells, Humans, In Vitro Techniques, KB Cells, Kinetics, Lipopeptides, Liver, Liver-Specific Organic Anion Transporter 1, Peptides, Cyclic, Perfusion, Plasmids, Protein Binding, Rats, Receptors, Cell Surface, Tissue Distribution, Transfection
Added March 27, 2014
1 Communities
1 Members
0 Resources
23 MeSH Terms
Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.
Lee W, Glaeser H, Smith LH, Roberts RL, Moeckel GW, Gervasini G, Leake BF, Kim RB
(2005) J Biol Chem 280: 9610-7
MeSH Terms: Amino Acid Sequence, Amino Acid Substitution, Brain, Enkephalin, D-Penicillamine (2,5)-, Estrone, Humans, Kidney, Kinetics, Liver, Liver-Specific Organic Anion Transporter 1, Models, Molecular, Molecular Sequence Data, Oligopeptides, Organ Specificity, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Protein Conformation, Protein Structure, Secondary
Added March 27, 2014
1 Communities
1 Members
0 Resources
18 MeSH Terms