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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 444

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Tuning Ligand Density To Optimize Pharmacokinetics of Targeted Nanoparticles for Dual Protection against Tumor-Induced Bone Destruction.
Vanderburgh J, Hill JL, Gupta MK, Kwakwa KA, Wang SK, Moyer K, Bedingfield SK, Merkel AR, d'Arcy R, Guelcher SA, Rhoades JA, Duvall CL
(2020) ACS Nano 14: 311-327
MeSH Terms: Animals, Antineoplastic Agents, Bone Neoplasms, Cell Line, Tumor, Cell Proliferation, Disease Models, Animal, Drug Screening Assays, Antitumor, Female, Humans, Ligands, Mice, Mice, Inbred C57BL, Mice, Knockout, Nanoparticles, Optical Imaging, Particle Size, Polymers, Pyridines, Surface Properties, Thiophenes, X-Ray Microtomography
Added March 19, 2020
0 Communities
3 Members
0 Resources
21 MeSH Terms
Ligand-conjugated quantum dots for fast sub-diffraction protein tracking in acute brain slices.
Thal LB, Mann VR, Sprinzen D, McBride JR, Reid KR, Tomlinson ID, McMahon DG, Cohen BE, Rosenthal SJ
(2020) Biomater Sci 8: 837-845
MeSH Terms: Animals, Brain, Brain Chemistry, Ligands, Mice, Microscopy, Fluorescence, Microtomy, Proteins, Quantum Dots, Selenium Compounds, Staining and Labeling, Zinc Compounds
Added March 18, 2020
0 Communities
2 Members
0 Resources
12 MeSH Terms
Kinetic Modeling of Steady-State Situations in Cytochrome P450 Enzyme Reactions.
Guengerich FP
(2019) Drug Metab Dispos 47: 1232-1239
MeSH Terms: Computer Simulation, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Kinetics, Ligands
Added March 3, 2020
0 Communities
1 Members
0 Resources
6 MeSH Terms
A unified structural model of the mammalian translocator protein (TSPO).
Xia Y, Ledwitch K, Kuenze G, Duran A, Li J, Sanders CR, Manning C, Meiler J
(2019) J Biomol NMR 73: 347-364
MeSH Terms: Animals, Bacterial Proteins, Ligands, Mammals, Mice, Mitochondrial Membrane Transport Proteins, Mitochondrial Permeability Transition Pore, Models, Molecular, Molecular Imaging, Nuclear Magnetic Resonance, Biomolecular, Protein Binding, Protein Conformation, Receptors, GABA
Added March 21, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes.
Guengerich FP, Wilkey CJ, Phan TTN
(2019) J Biol Chem 294: 10928-10941
MeSH Terms: Catalysis, Cytochrome P-450 CYP2D6, Cytochrome P-450 CYP2E1, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Kinetics, Lauric Acids, Ligands, Molecular Conformation, Oxidation-Reduction, Palmitic Acid, Protein Binding, Protein Conformation, Spiro Compounds, Substrate Specificity
Added March 3, 2020
0 Communities
1 Members
0 Resources
17 MeSH Terms
BCL::Mol2D-a robust atom environment descriptor for QSAR modeling and lead optimization.
Vu O, Mendenhall J, Altarawy D, Meiler J
(2019) J Comput Aided Mol Des 33: 477-486
MeSH Terms: Algorithms, Drug Design, Drug Discovery, Humans, Ligands, Quantitative Structure-Activity Relationship, Small Molecule Libraries
Added March 21, 2020
0 Communities
1 Members
0 Resources
7 MeSH Terms
Biotinylated-spiperone ligands for quantum dot labeling of the dopamine D2 receptor in live cell cultures.
Tomlinson ID, Kovtun O, Crescentini TM, Rosenthal SJ
(2019) Bioorg Med Chem Lett 29: 959-964
MeSH Terms: Biotin, Dopamine D2 Receptor Antagonists, HEK293 Cells, Humans, Ligands, Microscopy, Fluorescence, Quantum Dots, Receptors, Dopamine D2, Spiperone, Streptavidin
Added March 26, 2019
0 Communities
1 Members
0 Resources
10 MeSH Terms
BCL::MolAlign: Three-Dimensional Small Molecule Alignment for Pharmacophore Mapping.
Brown BP, Mendenhall J, Meiler J
(2019) J Chem Inf Model 59: 689-701
MeSH Terms: Cheminformatics, Ligands, Molecular Docking Simulation, Monte Carlo Method, Protein Conformation, Small Molecule Libraries
Added March 21, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Novel M positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands.
Poslusney MS, Salovich JM, Wood MR, Melancon BJ, Bollinger KA, Luscombe VB, Rodriguez AL, Engers DW, Bridges TM, Niswender CM, Conn PJ, Lindsley CW
(2019) Bioorg Med Chem Lett 29: 362-366
MeSH Terms: Allosteric Regulation, Amides, Dose-Response Relationship, Drug, Humans, Hydrogen Bonding, Ligands, Molecular Structure, Receptor, Muscarinic M4, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.
Felts AS, Bollinger KA, Brassard CJ, Rodriguez AL, Morrison RD, Scott Daniels J, Blobaum AL, Niswender CM, Jones CK, Conn PJ, Emmitte KA, Lindsley CW
(2019) Bioorg Med Chem Lett 29: 47-50
MeSH Terms: Allosteric Regulation, Animals, Dose-Response Relationship, Drug, Drug Discovery, Humans, Ligands, Molecular Structure, Picolinic Acids, Rats, Receptor, Metabotropic Glutamate 5, Structure-Activity Relationship
Added March 3, 2020
0 Communities
2 Members
0 Resources
MeSH Terms