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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 7 of 7

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A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2- Metastatic Breast Cancer.
Mayer IA, Abramson VG, Formisano L, Balko JM, Estrada MV, Sanders ME, Juric D, Solit D, Berger MF, Won HH, Li Y, Cantley LC, Winer E, Arteaga CL
(2017) Clin Cancer Res 23: 26-34
MeSH Terms: Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Aromatase Inhibitors, Biomarkers, Tumor, Breast Neoplasms, Cell Line, Tumor, DNA Mutational Analysis, Female, Humans, In Situ Hybridization, Fluorescence, Letrozole, Maximum Tolerated Dose, Middle Aged, Mutation, Neoplasm Metastasis, Neoplasm Staging, Nitriles, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Receptor, ErbB-2, Receptor, Fibroblast Growth Factor, Type 1, Receptors, Estrogen, Thiazoles, Treatment Outcome, Triazoles
Added April 6, 2017
0 Communities
1 Members
0 Resources
26 MeSH Terms
Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.
Mayer IA, Abramson VG, Isakoff SJ, Forero A, Balko JM, Kuba MG, Sanders ME, Yap JT, Van den Abbeele AD, Li Y, Cantley LC, Winer E, Arteaga CL
(2014) J Clin Oncol 32: 1202-9
MeSH Terms: Adult, Aged, Aminopyridines, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Cell Line, Tumor, Class I Phosphatidylinositol 3-Kinases, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Fluorodeoxyglucose F18, Humans, Letrozole, Middle Aged, Morpholines, Multimodal Imaging, Nitriles, Phosphoinositide-3 Kinase Inhibitors, Positron-Emission Tomography, Protein Kinase Inhibitors, Radiopharmaceuticals, Receptor, ErbB-2, Receptors, Estrogen, Tomography, X-Ray Computed, Triazoles
Added March 27, 2014
0 Communities
3 Members
0 Resources
26 MeSH Terms
Multicenter phase II study of neoadjuvant lapatinib and trastuzumab with hormonal therapy and without chemotherapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer: TBCRC 006.
Rimawi MF, Mayer IA, Forero A, Nanda R, Goetz MP, Rodriguez AA, Pavlick AC, Wang T, Hilsenbeck SG, Gutierrez C, Schiff R, Osborne CK, Chang JC
(2013) J Clin Oncol 31: 1726-31
MeSH Terms: Adult, Aged, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Hormonal, Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Drug Administration Schedule, Female, Humans, Lapatinib, Letrozole, Lymphatic Metastasis, Middle Aged, Neoadjuvant Therapy, Neoplasm Staging, Nitriles, Quinazolines, Receptor, ErbB-2, Receptors, Estrogen, Trastuzumab, Treatment Outcome, Triazoles, Up-Regulation
Added March 7, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Discordant cellular response to presurgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplification.
Balko JM, Mayer IA, Sanders ME, Miller TW, Kuba MG, Meszoely IM, Wagle N, Garraway LA, Arteaga CL
(2012) Mol Cancer Ther 11: 2301-5
MeSH Terms: Aromatase Inhibitors, Base Sequence, Breast Neoplasms, Drug Resistance, Neoplasm, Female, Gene Amplification, Humans, Letrozole, Middle Aged, Molecular Sequence Data, Mutation, Nitriles, Proto-Oncogene Proteins, Proto-Oncogene Proteins p21(ras), Receptor, Fibroblast Growth Factor, Type 1, Receptors, Estrogen, Triazoles, ras Proteins
Added September 3, 2013
0 Communities
6 Members
0 Resources
18 MeSH Terms
A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance.
Miller TW, Balko JM, Ghazoui Z, Dunbier A, Anderson H, Dowsett M, González-Angulo AM, Mills GB, Miller WR, Wu H, Shyr Y, Arteaga CL
(2011) Clin Cancer Res 17: 2024-34
MeSH Terms: Anastrozole, Antineoplastic Agents, Hormonal, Biomarkers, Tumor, Breast Neoplasms, Cell Line, Tumor, Cell Proliferation, Chemotherapy, Adjuvant, Disease-Free Survival, Drug Resistance, Neoplasm, Estrogen Receptor Modulators, Female, Gene Expression Profiling, Genetic Association Studies, Humans, Kaplan-Meier Estimate, Ki-67 Antigen, Letrozole, Neoadjuvant Therapy, Neoplasm Recurrence, Local, Neoplasms, Hormone-Dependent, Nitriles, Oligonucleotide Array Sequence Analysis, Proportional Hazards Models, Proto-Oncogene Proteins c-myc, RNA Interference, Tamoxifen, Treatment Outcome, Triazoles
Added February 13, 2014
1 Communities
3 Members
0 Resources
28 MeSH Terms
ErbB receptor signaling and therapeutic resistance to aromatase inhibitors.
Shin I, Miller T, Arteaga CL
(2006) Clin Cancer Res 12: 1008s-1012s
MeSH Terms: Acetyltransferases, Androstenedione, Aromatase Inhibitors, Breast Neoplasms, Carrier Proteins, Cell Line, Tumor, Corticosterone, Drug Resistance, Neoplasm, Female, Histone Acetyltransferases, Humans, Letrozole, Nitriles, Nuclear Receptor Coactivator 3, Oncogene Proteins, Promoter Regions, Genetic, Receptor, ErbB-2, Receptors, Estrogen, Signal Transduction, Trans-Activators, Transcriptional Activation, Triazoles
Added March 5, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Characterization of stable human aromatase expressed in E. coli.
Kagawa N, Hori H, Waterman MR, Yoshioka S
(2004) Steroids 69: 235-43
MeSH Terms: Amino Acid Sequence, Androstenedione, Arginine, Aromatase, Aromatase Inhibitors, Cell Membrane, Chaperonin 10, Chaperonin 60, Chloramphenicol, Cysteine, Electron Spin Resonance Spectroscopy, Enzyme Stability, Escherichia coli, Estradiol, Estrone, Fadrozole, Gene Expression, Humans, Letrozole, Molecular Sequence Data, Nitriles, Polymorphism, Genetic, Protein Structure, Secondary, Protein Synthesis Inhibitors, Recombinant Proteins, Solubility, Testosterone, Triazoles
Added February 12, 2015
0 Communities
1 Members
0 Resources
28 MeSH Terms