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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 22

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Supplementation of p40, a Lactobacillus rhamnosus GG-derived protein, in early life promotes epidermal growth factor receptor-dependent intestinal development and long-term health outcomes.
Shen X, Liu L, Peek RM, Acra SA, Moore DJ, Wilson KT, He F, Polk DB, Yan F
(2018) Mucosal Immunol 11: 1316-1328
MeSH Terms: Animals, Bacterial Proteins, Cell Differentiation, Cell Proliferation, Epithelial Cells, ErbB Receptors, Female, Hydrogels, Immunity, Innate, Immunoglobulin A, Intestinal Mucosa, Lactobacillus rhamnosus, Mice, Mice, Inbred C57BL, Probiotics, T-Lymphocytes, Regulatory, Tight Junctions, Time, Transcriptional Activation
Added June 8, 2018
0 Communities
2 Members
0 Resources
19 MeSH Terms
Nasopharyngeal Lactobacillus is associated with a reduced risk of childhood wheezing illnesses following acute respiratory syncytial virus infection in infancy.
Rosas-Salazar C, Shilts MH, Tovchigrechko A, Schobel S, Chappell JD, Larkin EK, Gebretsadik T, Halpin RA, Nelson KE, Moore ML, Anderson LJ, Peebles RS, Das SR, Hartert TV
(2018) J Allergy Clin Immunol 142: 1447-1456.e9
MeSH Terms: Acute Disease, Child, Preschool, Cohort Studies, Female, Humans, Infant, Lactobacillus, Male, Microbiota, Nasopharynx, RNA, Ribosomal, 16S, Respiratory Sounds, Respiratory Syncytial Virus Infections, Risk
Added March 14, 2018
0 Communities
1 Members
0 Resources
14 MeSH Terms
An LGG-derived protein promotes IgA production through upregulation of APRIL expression in intestinal epithelial cells.
Wang Y, Liu L, Moore DJ, Shen X, Peek RM, Acra SA, Li H, Ren X, Polk DB, Yan F
(2017) Mucosal Immunol 10: 373-384
MeSH Terms: Animals, Antibody Formation, B-Lymphocytes, Bacterial Proteins, Cells, Cultured, Epithelial Cells, ErbB Receptors, Immunoglobulin A, Intestine, Small, Lactobacillus rhamnosus, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, RNA, Small Interfering, Transcriptional Activation, Tumor Necrosis Factor Ligand Superfamily Member 13, Up-Regulation
Added June 30, 2016
0 Communities
2 Members
0 Resources
18 MeSH Terms
Neonatal colonization of mice with LGG promotes intestinal development and decreases susceptibility to colitis in adulthood.
Yan F, Liu L, Cao H, Moore DJ, Washington MK, Wang B, Peek RM, Acra SA, Polk DB
(2017) Mucosal Immunol 10: 117-127
MeSH Terms: Animals, Animals, Newborn, Cell Proliferation, Cells, Cultured, Colitis, Dextran Sulfate, Disease Models, Animal, Female, Gastrointestinal Microbiome, Humans, Immunoglobulin A, Intestinal Mucosa, Intestines, Lactobacillus rhamnosus, Mice, Mice, Inbred C57BL, Pregnancy, Probiotics, Symbiosis, Tight Junctions
Added April 26, 2016
0 Communities
2 Members
0 Resources
20 MeSH Terms
Activation of epidermal growth factor receptor mediates mucin production stimulated by p40, a Lactobacillus rhamnosus GG-derived protein.
Wang L, Cao H, Liu L, Wang B, Walker WA, Acra SA, Yan F
(2014) J Biol Chem 289: 20234-44
MeSH Terms: Animals, Apoptosis, Bacterial Proteins, Cell Line, Colon, ErbB Receptors, Humans, Intestinal Mucosa, Lactobacillus rhamnosus, Mice, Mice, Inbred C57BL, Mice, Knockout, Mucin-2, Mucins, Probiotics, RNA, Small Interfering, Transcriptional Activation, Up-Regulation
Added October 8, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor.
Yan F, Liu L, Dempsey PJ, Tsai YH, Raines EW, Wilson CL, Cao H, Cao Z, Liu L, Polk DB
(2013) J Biol Chem 288: 30742-30751
MeSH Terms: ADAM Proteins, ADAM17 Protein, Animals, Bacterial Proteins, Cell Line, Tumor, Enzyme Activation, Epithelial Cells, ErbB Receptors, Gene Expression Regulation, Enzymologic, Gene Knockdown Techniques, Heparin-binding EGF-like Growth Factor, Humans, Intercellular Signaling Peptides and Proteins, Intestinal Mucosa, Lactobacillus rhamnosus, Mice, Mice, Knockout, Probiotics, Proto-Oncogene Proteins c-akt, Transcriptional Activation, Transforming Growth Factor alpha, Up-Regulation
Added May 19, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis.
Lertpiriyapong K, Whary MT, Muthupalani S, Lofgren JL, Gamazon ER, Feng Y, Ge Z, Wang TC, Fox JG
(2014) Gut 63: 54-63
MeSH Terms: Adenocarcinoma, Animals, Bacteroides, Biomarkers, Biomarkers, Tumor, Carcinogenesis, Clostridium, Cytokines, Female, Gastric Mucosa, Gastritis, Atrophic, Helicobacter Infections, Helicobacter pylori, Intestine, Large, Lactobacillus, Male, Mice, Specific Pathogen-Free Organisms, Stomach Neoplasms, Symbiosis
Added April 13, 2017
0 Communities
1 Members
0 Resources
20 MeSH Terms
Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases.
Yan F, Polk DB
(2012) Gut Microbes 3: 25-8
MeSH Terms: Apoptosis, Bacterial Proteins, Cloning, Molecular, Epithelial Cells, ErbB Receptors, Humans, Hydrogel, Polyethylene Glycol Dimethacrylate, Immunologic Factors, Inflammatory Bowel Diseases, Lactobacillus rhamnosus, Probiotics
Added May 19, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Probiotics and immune health.
Yan F, Polk DB
(2011) Curr Opin Gastroenterol 27: 496-501
MeSH Terms: Adaptive Immunity, Bacterial Proteins, Humans, Immunity, Intestinal Diseases, Lactobacillus, Probiotics
Added May 19, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.
Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM, Wilson KT, Polk DB
(2011) J Clin Invest 121: 2242-53
MeSH Terms: Administration, Rectal, Animals, Apoptosis, Bacterial Proteins, Colitis, Dextran Sulfate, Drug Evaluation, Preclinical, Enzyme Activation, Epithelial Cells, ErbB Receptors, Hydrogels, Intestinal Mucosa, Lactobacillus rhamnosus, Mice, Mice, Inbred C57BL, Microspheres, Oxazolone, Permeability, Probiotics, Proto-Oncogene Proteins c-akt, Quinazolines, Recombinant Proteins, Signal Transduction, Tyrphostins
Added March 5, 2014
0 Communities
6 Members
0 Resources
24 MeSH Terms