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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 17

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Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies.
Wirtz ED, Hoshino D, Maldonado AT, Tyson DR, Weaver AM
(2015) JAMA Otolaryngol Head Neck Surg 141: 543-9
MeSH Terms: Benzoquinones, Carcinoma, Squamous Cell, Cell Line, Tumor, Cell Survival, Class I Phosphatidylinositol 3-Kinases, Head and Neck Neoplasms, Humans, Imidazoles, Indazoles, Inhibitory Concentration 50, Lactams, Macrocyclic, Molecular Targeted Therapy, Mutation, Phosphatidylinositol 3-Kinases, Protein-Serine-Threonine Kinases, Pyridones, Pyrimidinones, Quinolines, Squamous Cell Carcinoma of Head and Neck, Sulfonamides, TOR Serine-Threonine Kinases, Tumor Cells, Cultured
Added February 15, 2016
1 Communities
1 Members
0 Resources
22 MeSH Terms
Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
He K, Zheng X, Zhang L, Yu J
(2013) Mol Cancer Ther 12: 2559-68
MeSH Terms: Animals, Apoptosis, Apoptosis Regulatory Proteins, Benzoquinones, Cell Line, Tumor, Colorectal Neoplasms, DNA Damage, HCT116 Cells, HSP90 Heat-Shock Proteins, Humans, Isoxazoles, Lactams, Macrocyclic, Mice, Mice, Nude, Mitochondria, Proto-Oncogene Proteins, Resorcinols, Tumor Suppressor Protein p53, Xenograft Model Antitumor Assays, bcl-2-Associated X Protein
Added July 28, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Targeted protein capture for analysis of electrophile-protein adducts.
Connor RE, Codreanu SG, Marnett LJ, Liebler DC
(2013) Methods Mol Biol 987: 163-76
MeSH Terms: Affinity Labels, Aldehydes, Benzoquinones, Blotting, Western, Cell Line, Tumor, Databases, Protein, Electrons, HSP90 Heat-Shock Proteins, Humans, Immunoprecipitation, Lactams, Macrocyclic, Mass Spectrometry, Protein Structure, Tertiary, Trypsin
Added March 20, 2014
0 Communities
2 Members
0 Resources
14 MeSH Terms
Why is this effective HSP90 inhibitor not being developed in HER2+ breast cancer?
Arteaga CL
(2011) Clin Cancer Res 17: 4919-21
MeSH Terms: Antibodies, Monoclonal, Humanized, Antineoplastic Combined Chemotherapy Protocols, Benzoquinones, Breast Neoplasms, Female, Genes, erbB-2, HSP90 Heat-Shock Proteins, Humans, Lactams, Macrocyclic, Male, Trastuzumab
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Protein complex formation with heat shock protein 90 in chronic hypoxia-induced pulmonary hypertension in newborn piglets.
Fike CD, Pfister SL, Slaughter JC, Kaplowitz MR, Zhang Y, Zeng H, Frye NR, Aschner JL
(2010) Am J Physiol Heart Circ Physiol 299: H1190-204
MeSH Terms: Animals, Animals, Newborn, Benzoquinones, Cytochrome P-450 Enzyme System, Disease Models, Animal, Enzyme Inhibitors, HSP90 Heat-Shock Proteins, Hypertension, Pulmonary, Hypoxia, Intramolecular Oxidoreductases, Lactams, Macrocyclic, Nitric Oxide Synthase, Nitric Oxide Synthase Type III, Pulmonary Artery, Signal Transduction, Swine, Thromboxane-A Synthase, Vascular Resistance
Added May 20, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells.
Rao R, Nalluri S, Fiskus W, Balusu R, Joshi A, Mudunuru U, Buckley KM, Robbins K, Ustun C, Reuther GW, Bhalla KN
(2010) Mol Cancer Ther 9: 2232-42
MeSH Terms: Animals, Benzoquinones, Bone Marrow Cells, Carbazoles, Cell Differentiation, Cell Line, Tumor, Coculture Techniques, HSP90 Heat-Shock Proteins, Humans, Indole Alkaloids, Lactams, Macrocyclic, Leukemia, Myeloid, Acute, Nerve Growth Factor, PC12 Cells, Phosphorylation, Polyubiquitin, Proteasome Endopeptidase Complex, Rats, Receptor, trkA, Signal Transduction, Stromal Cells, Ubiquitination
Added April 1, 2013
0 Communities
1 Members
0 Resources
22 MeSH Terms
Mitogen-activated protein kinases and NFkappaB are involved in SP-A-enhanced responses of macrophages to mycobacteria.
Lopez JP, Vigerust DJ, Shepherd VL
(2009) Respir Res 10: 60
MeSH Terms: Animals, Benzoquinones, Blotting, Western, Bone Marrow Cells, Electrophoretic Mobility Shift Assay, Enzyme Inhibitors, Female, Humans, Immunoprecipitation, Lactams, Macrocyclic, Macrophages, Mice, Mitogen-Activated Protein Kinases, Mycobacterium bovis, NF-kappa B, Nitric Oxide, Phagocytosis, Pulmonary Surfactant-Associated Protein A, Rats, Rats, Sprague-Dawley, Rifabutin
Added March 22, 2016
0 Communities
1 Members
0 Resources
21 MeSH Terms
Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway.
Vilar E, Mukherjee B, Kuick R, Raskin L, Misek DE, Taylor JM, Giordano TJ, Hanash SM, Fearon ER, Rennert G, Gruber SB
(2009) Clin Cancer Res 15: 2829-39
MeSH Terms: Algorithms, Antineoplastic Agents, Benzoquinones, Cell Cycle, Cell Line, Tumor, Chromones, Colorectal Neoplasms, Computational Biology, DNA Mismatch Repair, Drug Evaluation, Preclinical, Enzyme Inhibitors, Gene Expression Profiling, Humans, Hydroxamic Acids, Immunosuppressive Agents, Lactams, Macrocyclic, Microsatellite Instability, Morpholines, Phosphoinositide-3 Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Sirolimus
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives.
Fukuyo Y, Inoue M, Nakajima T, Higashikubo R, Horikoshi NT, Hunt C, Usheva A, Freeman ML, Horikoshi N
(2008) Cancer Res 68: 6324-30
MeSH Terms: Acetylcysteine, Antibiotics, Antineoplastic, Benzoquinones, Cell Line, Tumor, Enzyme Activation, HSP90 Heat-Shock Proteins, Humans, Lactams, Macrocyclic, Mitogen-Activated Protein Kinases, Mutation, Oxidative Stress, Proto-Oncogene Proteins B-raf
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors.
Regales L, Balak MN, Gong Y, Politi K, Sawai A, Le C, Koutcher JA, Solit DB, Rosen N, Zakowski MF, Pao W
(2007) PLoS One 2: e810
MeSH Terms: Animals, Antineoplastic Agents, Benzoquinones, Disease Models, Animal, Drug Resistance, Neoplasm, ErbB Receptors, Genotype, HSP90 Heat-Shock Proteins, Lactams, Macrocyclic, Lung Neoplasms, Mice, Mice, Transgenic, Mutation, Protein Kinase Inhibitors
Added March 24, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms