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Results: 1 to 9 of 9

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Regulation of Selenium Metabolism and Transport.
Burk RF, Hill KE
(2015) Annu Rev Nutr 35: 109-34
MeSH Terms: Animals, Biological Availability, Biological Transport, Biomarkers, Diet, Dietary Supplements, Health Status, Homeostasis, Humans, Kidney Tubules, Proximal, LDL-Receptor Related Proteins, Liver, Low Density Lipoprotein Receptor-Related Protein-2, Nutritional Requirements, Organ Specificity, Selenium, Selenocysteine, Selenomethionine, Selenoprotein P, Selenoproteins
Added September 28, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration.
Burk RF, Hill KE, Motley AK, Winfrey VP, Kurokawa S, Mitchell SL, Zhang W
(2014) FASEB J 28: 3579-88
MeSH Terms: Animals, Animals, Congenic, Biological Transport, Blood-Brain Barrier, Brain, Capillaries, Choroid Plexus, Endocytosis, Endothelial Cells, Female, LDL-Receptor Related Proteins, Low Density Lipoprotein Receptor-Related Protein-2, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Nerve Degeneration, Neurons, Pregnancy, Selenium, Selenoprotein P
Added September 28, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
Maternal-fetal transfer of selenium in the mouse.
Burk RF, Olson GE, Hill KE, Winfrey VP, Motley AK, Kurokawa S
(2013) FASEB J 27: 3249-56
MeSH Terms: Animals, Biological Transport, Female, Glutathione Peroxidase, Immunohistochemistry, LDL-Receptor Related Proteins, Low Density Lipoprotein Receptor-Related Protein-2, Male, Maternal-Fetal Exchange, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Fluorescence, Placenta, Pregnancy, Selenium, Selenoprotein P, Time Factors, Yolk Sac
Added March 7, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Long isoform mouse selenoprotein P (Sepp1) supplies rat myoblast L8 cells with selenium via endocytosis mediated by heparin binding properties and apolipoprotein E receptor-2 (ApoER2).
Kurokawa S, Hill KE, McDonald WH, Burk RF
(2012) J Biol Chem 287: 28717-26
MeSH Terms: Animals, Cell Line, Chlorates, Endocytosis, Glutathione Peroxidase, LDL-Receptor Related Proteins, Low Density Lipoprotein Receptor-Related Protein-1, Lysosomes, Mice, Mice, Knockout, Myoblasts, Protein Isoforms, Rats, Receptors, LDL, Selenoproteins, Tumor Suppressor Proteins
Added March 7, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
A p120-catenin-CK1epsilon complex regulates Wnt signaling.
Casagolda D, Del Valle-Pérez B, Valls G, Lugilde E, Vinyoles M, Casado-Vela J, Solanas G, Batlle E, Reynolds AB, Casal JI, de Herreros AG, Duñach M
(2010) J Cell Sci 123: 2621-31
MeSH Terms: Adaptor Proteins, Signal Transducing, Cadherins, Casein Kinase 1 epsilon, Catenins, Cell Line, Tumor, Dishevelled Proteins, Humans, Immunoprecipitation, LDL-Receptor Related Proteins, Low Density Lipoprotein Receptor-Related Protein-5, Low Density Lipoprotein Receptor-Related Protein-6, Mass Spectrometry, Phosphoproteins, Phosphorylation, Protein Binding, Signal Transduction, Wnt Proteins
Added March 28, 2014
1 Communities
1 Members
0 Resources
17 MeSH Terms
Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.
Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E
(2010) Sci Signal 3: ra37
MeSH Terms: Animals, Drosophila melanogaster, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Glycogen Synthase Kinase 3, HeLa Cells, Humans, LDL-Receptor Related Proteins, Low Density Lipoprotein Receptor-Related Protein-6, Signal Transduction, Transcription, Genetic, Wnt Proteins, Xenopus laevis, beta Catenin, beta-Adrenergic Receptor Kinases
Added December 10, 2013
0 Communities
3 Members
0 Resources
15 MeSH Terms
Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2).
White-Adams TC, Berny MA, Tucker EI, Gertz JM, Gailani D, Urbanus RT, de Groot PG, Gruber A, McCarty OJ
(2009) Arterioscler Thromb Vasc Biol 29: 1602-7
MeSH Terms: Animals, Blood Platelets, Calcium, Factor XI, Humans, Kininogen, High-Molecular-Weight, LDL-Receptor Related Proteins, Ligands, Mice, Mice, Inbred C57BL, Platelet Adhesiveness, Receptors, Lipoprotein, Zinc
Added May 19, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Neurodegeneration in mice resulting from loss of functional selenoprotein P or its receptor apolipoprotein E receptor 2.
Valentine WM, Abel TW, Hill KE, Austin LM, Burk RF
(2008) J Neuropathol Exp Neurol 67: 68-77
MeSH Terms: Animals, Brain, Gene Deletion, Glial Fibrillary Acidic Protein, Imaging, Three-Dimensional, LDL-Receptor Related Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Nerve Degeneration, Receptors, Lipoprotein, Selenoprotein P, Silver Staining
Added March 5, 2014
0 Communities
2 Members
0 Resources
13 MeSH Terms
Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed.
Burk RF, Hill KE, Olson GE, Weeber EJ, Motley AK, Winfrey VP, Austin LM
(2007) J Neurosci 27: 6207-11
MeSH Terms: Animals, Brain, Death, Diet, Gene Deletion, LDL-Receptor Related Proteins, Male, Malnutrition, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Nervous System Diseases, Receptors, Lipoprotein, Selenium
Added August 22, 2011
1 Communities
0 Members
0 Resources
15 MeSH Terms