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Kidney cancer: the Cytokine Working Group experience (1986-2001): part I. IL-2-based clinical trials.
Atkins MB, Dutcher J, Weiss G, Margolin K, Clark J, Sosman J, Logan T, Aronson F, Mier J, Cytokine Working Group
(2001) Med Oncol 18: 197-207
MeSH Terms: Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Renal Cell, Cytokines, Humans, Interferon-alpha, Interleukin-2, Kidney Neoplasms, Killer Cells, Lymphokine-Activated, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Treatment Outcome
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo.
Assarsson E, Kambayashi T, Sandberg JK, Hong S, Taniguchi M, Van Kaer L, Ljunggren HG, Chambers BJ
(2000) J Immunol 165: 3673-9
MeSH Terms: Animals, Antigens, Antigens, Ly, Antigens, Surface, CD8-Positive T-Lymphocytes, Cell Differentiation, Cells, Cultured, Cytokines, Dose-Response Relationship, Immunologic, Influenza A virus, Killer Cells, Lymphokine-Activated, Kinetics, Lectins, C-Type, Lymphocyte Activation, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Lymphopenia, Membrane Glycoproteins, Mice, Mice, Inbred C57BL, Mice, Knockout, NK Cell Lectin-Like Receptor Subfamily B, Orthomyxoviridae Infections, Protein Biosynthesis, Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-fyn, Receptors, Interleukin-2, Receptors, NK Cell Lectin-Like, Stem Cells, T-Lymphocyte Subsets, Up-Regulation
Added December 10, 2013
0 Communities
1 Members
0 Resources
31 MeSH Terms
Activated alpha 2-macroglobulin reverses the immunosuppressive activity in human breast cancer cell-conditioned medium by selectively neutralizing transforming growth factor-beta in the presence of interleukin-2.
Harthun NL, Weaver AM, Brinckerhoff LH, Deacon DH, Gonias SL, Slingluff CL
(1998) J Immunother 21: 85-94
MeSH Terms: Breast Neoplasms, Cells, Cultured, Culture Media, Conditioned, Culture Media, Serum-Free, Cytokines, Female, Humans, Immune Tolerance, Interleukin-10, Interleukin-2, Killer Cells, Lymphokine-Activated, Killer Cells, Natural, Neutralization Tests, T-Lymphocytes, Cytotoxic, Transforming Growth Factor beta, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, alpha-Macroglobulins
Added March 5, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Murine platelet endothelial cell adhesion molecule (PECAM-1)/CD31 modulates beta 2 integrins on lymphokine-activated killer cells.
Piali L, Albelda SM, Baldwin HS, Hammel P, Gisler RH, Imhof BA
(1993) Eur J Immunol 23: 2464-71
MeSH Terms: Amino Acid Sequence, Animals, Antigens, Differentiation, Myelomonocytic, Blood Platelets, Cell Adhesion, Cell Adhesion Molecules, Cell Line, Endothelium, Vascular, Female, Integrins, Killer Cells, Lymphokine-Activated, Lymphocyte Subsets, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Platelet Endothelial Cell Adhesion Molecule-1
Added June 11, 2010
1 Communities
1 Members
0 Resources
16 MeSH Terms
A phase IA/IB trial of anti-CD3 murine monoclonal antibody plus low-dose continuous-infusion interleukin-2 in advanced cancer patients.
Sosman JA, Kefer C, Fisher RI, Jacobs CD, Pumfery P, Ellis TM
(1995) J Immunother Emphasis Tumor Immunol 17: 171-80
MeSH Terms: Adult, Aged, Antibodies, Anti-Idiotypic, Antigens, CD, Female, Humans, Interleukin-2, Killer Cells, Lymphokine-Activated, Lymphocyte Count, Male, Middle Aged, Muromonab-CD3, Neoplasms
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
A phase I trial of continuous infusion interleukin-4 (IL-4) alone and following interleukin-2 (IL-2) in cancer patients.
Sosman JA, Fisher SG, Kefer C, Fisher RI, Ellis TM
(1994) Ann Oncol 5: 447-52
MeSH Terms: Adult, Aged, Antigens, CD, Antigens, Differentiation, T-Lymphocyte, CD56 Antigen, Drug Administration Schedule, Edema, Eosinophilia, Eosinophils, Female, Humans, Infusions, Intravenous, Interleukin-2, Interleukin-4, Killer Cells, Lymphokine-Activated, Killer Cells, Natural, Leukocyte Count, Male, Middle Aged, Neoplasms
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Repetitive weekly cycles of interleukin 2: effect of outpatient treatment with a lower dose of interleukin 2 on non-major histocompatibility complex-restricted killer activity.
Goldstein D, Sosman JA, Hank JA, Weil-Hillman G, Moore KH, Borchert A, Bechhofer R, Storer B, Kohler PC, Levitt D
(1989) Cancer Res 49: 6832-9
MeSH Terms: Adult, Antigens, CD, Antigens, Differentiation, T-Lymphocyte, Cytotoxicity, Immunologic, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Humans, Interleukin-2, Killer Cells, Lymphokine-Activated, Killer Cells, Natural, Leukocyte Count, Lymphocyte Activation, Male, Middle Aged, Outpatients, Time Factors
Added March 5, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
The clinical immunobiology of interleukin-2: potential modified uses for improved cancer treatment.
Voss SD, Weil-Hillman G, Hank JA, Sosman JA, Sondel PM
(1989) Bull N Y Acad Med 65: 93-110
MeSH Terms: Animals, Cytotoxicity, Immunologic, Drug Evaluation, Forecasting, Histocompatibility Antigens, Humans, Immunotherapy, Interleukin-2, Killer Cells, Lymphokine-Activated, Lymphocyte Activation, Neoplasms
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
In vivo activation of lymphokine-activated killer activity with interleukin-2: prospects for combination therapies.
Sosman JA, Hank JA, Sondel PM
(1990) Semin Oncol 17: 22-30; discussion 38-41
MeSH Terms: Antibodies, Monoclonal, Blood Transfusion, Combined Modality Therapy, Humans, Immunization, Passive, Interferon Type I, Interleukin-2, Killer Cells, Lymphokine-Activated, Lymphocyte Activation, Neoplasms, Recombinant Proteins, Time Factors
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Addition of interleukin-2 in vitro augments detection of lymphokine-activated killer activity generated in vivo.
Hank JA, Weil-Hillman G, Surfus JE, Sosman JA, Sondel PM
(1990) Cancer Immunol Immunother 31: 53-9
MeSH Terms: Cells, Cultured, Cytotoxicity, Immunologic, Dose-Response Relationship, Drug, Humans, In Vitro Techniques, Interleukin-2, Killer Cells, Lymphokine-Activated, Recombinant Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms