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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 13

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Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.
Hargrove TY, Garvey EP, Hoekstra WJ, Yates CM, Wawrzak Z, Rachakonda G, Villalta F, Lepesheva GI
(2017) Antimicrob Agents Chemother 61:
MeSH Terms: Antifungal Agents, Aspergillus fumigatus, Candida albicans, Drugs, Investigational, Fluconazole, Ketoconazole, Microbial Sensitivity Tests, Pyridines, Sterol 14-Demethylase, Tetrazoles, Triazoles, Voriconazole
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactions.
Blobaum AL, Bridges TM, Byers FW, Turlington ML, Mattmann ME, Morrison RD, Mackie C, Lavreysen H, Bartolomé JM, Macdonald GJ, Steckler T, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Stauffer SR, Daniels JS
(2013) Drug Metab Dispos 41: 2066-75
MeSH Terms: Allosteric Regulation, Animals, Cytochrome P-450 CYP3A, Drug Interactions, Hepatocytes, Humans, Intestinal Mucosa, Intestines, Ketoconazole, Kinetics, Liver, Male, Mice, Microsomes, Microsomes, Liver, Midazolam, Mixed Function Oxygenases, Rats, Rats, Sprague-Dawley
Added February 19, 2015
0 Communities
3 Members
0 Resources
19 MeSH Terms
High-throughput fluorescence assay of cytochrome P450 3A4.
Cheng Q, Guengerich FP
(2013) Methods Mol Biol 987: 157-62
MeSH Terms: Coumarins, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Enzyme Assays, Humans, Inhibitory Concentration 50, Ketoconazole, Spectrometry, Fluorescence
Added March 26, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Cimetidine-associated patent ductus arteriosus is mediated via a cytochrome P450 mechanism independent of H2 receptor antagonism.
Cotton RB, Shah LP, Poole SD, Ehinger NJ, Brown N, Shelton EL, Slaughter JC, Baldwin HS, Paria BC, Reese J
(2013) J Mol Cell Cardiol 59: 86-94
MeSH Terms: Cimetidine, Cytochrome P-450 Enzyme System, Ductus Arteriosus, Patent, Histamine H2 Antagonists, Humans, Immunohistochemistry, Infant, Newborn, Ketoconazole, Polymerase Chain Reaction, Randomized Controlled Trials as Topic, Ranitidine, Receptors, Histamine, Retrospective Studies
Added April 9, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
High-throughput fluorescence assay of cytochrome P450 3A4.
Cheng Q, Sohl CD, Guengerich FP
(2009) Nat Protoc 4: 1258-61
MeSH Terms: Coumarins, Cytochrome P-450 CYP3A, Humans, Inhibitory Concentration 50, Ketoconazole, Oxidation-Reduction, Software, Spectrometry, Fluorescence
Added March 26, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis.
Yang S, Wei S, Pozzi A, Capdevila JH
(2009) Arch Biochem Biophys 489: 82-91
MeSH Terms: Animals, Antifungal Agents, Cell Proliferation, Cells, Cultured, Cytochrome P-450 CYP2J2, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 2, Endothelial Cells, Enzyme Activation, Ketoconazole, Lung, MAP Kinase Signaling System, Mice, Mice, Transgenic, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Neovascularization, Physiologic, Phosphorylation, Proto-Oncogene Proteins c-akt, RNA, Small Interfering, Vascular Endothelial Growth Factor A
Added February 24, 2014
0 Communities
2 Members
0 Resources
22 MeSH Terms
Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents.
Lamb DC, Kelly DE, Waterman MR, Stromstedt M, Rozman D, Kelly SL
(1999) Yeast 15: 755-63
MeSH Terms: Antifungal Agents, Binding Sites, Candida albicans, Carbon Monoxide, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Formates, Humans, Inhibitory Concentration 50, Itraconazole, Ketoconazole, Kinetics, Ligands, Oxidoreductases, Recombinant Proteins, Spectrum Analysis, Sterol 14-Demethylase, Titrimetry
Added February 12, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples.
Yamazaki H, Inoue K, Shaw PM, Checovich WJ, Guengerich FP, Shimada T
(1997) J Pharmacol Exp Ther 283: 434-42
MeSH Terms: Animals, Anti-Ulcer Agents, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C19, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, Fluvoxamine, Humans, Hydroxylation, Ketoconazole, Microsomes, Liver, Mixed Function Oxygenases, Omeprazole, Rabbits, Recombinant Proteins, Sulfaphenazole
Added May 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: counterregulation of hyperfiltration.
Takahashi K, Harris RC, Capdevila JH, Karara A, Makita K, Jacobson HR, Munger KA, Badr KF
(1993) J Am Soc Nephrol 3: 1496-500
MeSH Terms: Alkaline Phosphatase, Animals, Arachidonic Acid, Cytochrome P-450 CYP2J2, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Glomerular Filtration Rate, Ketoconazole, Kidney, Male, Microsomes, Nephrectomy, Oxygenases, Rats, Rats, Wistar, Renal Circulation, Sodium-Potassium-Exchanging ATPase
Added August 19, 2013
1 Communities
1 Members
0 Resources
17 MeSH Terms
Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase.
Swart P, Swart AC, Waterman MR, Estabrook RW, Mason JI
(1993) J Clin Endocrinol Metab 77: 98-102
MeSH Terms: 17-alpha-Hydroxyprogesterone, Adrenal Glands, Animals, Aryl Hydrocarbon Hydroxylases, Cell Line, Transformed, Chlorocebus aethiops, Cytochrome P-450 CYP2C8, Cytochrome P-450 CYP2C9, DNA, Humans, Hydroxyprogesterones, Ketoconazole, Kidney, Kinetics, Male, Microsomes, NADP, Pregnenolone, Progesterone, Steroid 16-alpha-Hydroxylase, Steroid 17-alpha-Hydroxylase, Steroid Hydroxylases, Testis, Transfection
Added February 12, 2015
0 Communities
1 Members
0 Resources
24 MeSH Terms