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Results: 1 to 7 of 7

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7-Ketocholesterol in disease and aging.
Anderson A, Campo A, Fulton E, Corwin A, Jerome WG, O'Connor MS
(2020) Redox Biol 29: 101380
MeSH Terms: Humans, Ketocholesterols
Added March 3, 2020
0 Communities
1 Members
0 Resources
2 MeSH Terms
On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO.
Björkhem I, Diczfalusy U, Lövgren-Sandblom A, Starck L, Jonsson M, Tallman K, Schirmer H, Ousager LB, Crick PJ, Wang Y, Griffiths WJ, Guengerich FP
(2014) J Lipid Res 55: 1165-72
MeSH Terms: Adolescent, Adult, Child, Cholesterol 7-alpha-Hydroxylase, Dehydrocholesterols, Down-Regulation, Female, Gene Expression Regulation, Enzymologic, Humans, Ketocholesterols, Smith-Lemli-Opitz Syndrome, Xanthomatosis, Cerebrotendinous
Added May 26, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells.
Wang SF, Chou YC, Mazumder N, Kao FJ, Nagy LD, Guengerich FP, Huang C, Lee HC, Lai PS, Ueng YF
(2013) Biochem Pharmacol 86: 548-60
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Acetylcysteine, Antibiotics, Antineoplastic, Antioxidants, Carcinoma, Hepatocellular, Cell Line, Cell Line, Tumor, Cell Survival, Cholesterol, Doxorubicin, Drug Resistance, Neoplasm, Hepatocytes, Humans, Hydroxycholesterols, Ketocholesterols, Lactic Acid, Oligomycins, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Signal Transduction, TOR Serine-Threonine Kinases, Up-Regulation
Added March 7, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome.
Xu L, Sheflin LG, Porter NA, Fliesler SJ
(2012) Biochim Biophys Acta 1821: 877-83
MeSH Terms: Animals, Animals, Newborn, Cholesterol, Chromatography, High Pressure Liquid, Dehydrocholesterols, Disease Models, Animal, Female, Humans, Ketocholesterols, Male, Mass Spectrometry, Molecular Structure, Pregnancy, Rats, Rats, Sprague-Dawley, Retina, Retinal Degeneration, Smith-Lemli-Opitz Syndrome, trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
Added March 20, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome.
Xu L, Liu W, Sheflin LG, Fliesler SJ, Porter NA
(2011) J Lipid Res 52: 1810-20
MeSH Terms: Animals, Anticholesteremic Agents, Cholestenones, Cholesterol, Chromatography, High Pressure Liquid, Dehydrocholesterols, Disease Models, Animal, Hydroxycholesterols, Ketocholesterols, Lipid Peroxidation, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mice, Rats, Rats, Sprague-Dawley, Smith-Lemli-Opitz Syndrome, Spectrophotometry, Ultraviolet, Sterols, trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
Added March 7, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.
Shinkyo R, Xu L, Tallman KA, Cheng Q, Porter NA, Guengerich FP
(2011) J Biol Chem 286: 33021-8
MeSH Terms: Biocatalysis, Cholesterol, Cholesterol 7-alpha-Hydroxylase, Chromatography, Liquid, Cytochrome P-450 Enzyme System, Dehydrocholesterols, Epoxy Compounds, Humans, Ketocholesterols, Mass Spectrometry, Microsomes, Liver, Oxidation-Reduction, Recombinant Proteins
Added March 7, 2014
0 Communities
2 Members
0 Resources
13 MeSH Terms
Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages.
Freeman NE, Rusinol AE, Linton M, Hachey DL, Fazio S, Sinensky MS, Thewke D
(2005) J Lipid Res 46: 1933-43
MeSH Terms: Animals, Apoptosis, Arachidonic Acid, Carbon Radioisotopes, Caspase 3, Caspases, Cell Line, Cholesterol Esters, Enzyme Inhibitors, Esterification, In Situ Nick-End Labeling, Ketocholesterols, Lipoproteins, LDL, Macrophages, Macrophages, Peritoneal, Mice, Mice, Inbred C57BL, Phospholipases A, Phospholipases A2, Sterol O-Acyltransferase, Tritium
Added March 20, 2014
0 Communities
2 Members
0 Resources
21 MeSH Terms