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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 44

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Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state.
Taylor KC, Kang PW, Hou P, Yang ND, Kuenze G, Smith JA, Shi J, Huang H, White KM, Peng D, George AL, Meiler J, McFeeters RL, Cui J, Sanders CR
(2020) Elife 9:
MeSH Terms: Animals, Electrophysiology, Fluorometry, Humans, KCNQ1 Potassium Channel, Magnetic Resonance Spectroscopy, Oocytes, Patch-Clamp Techniques, Protein Structure, Tertiary, Xenopus laevis
Added March 3, 2020
0 Communities
2 Members
0 Resources
10 MeSH Terms
Upgraded molecular models of the human KCNQ1 potassium channel.
Kuenze G, Duran AM, Woods H, Brewer KR, McDonald EF, Vanoye CG, George AL, Sanders CR, Meiler J
(2019) PLoS One 14: e0220415
MeSH Terms: Humans, Hydrogen Bonding, KCNQ1 Potassium Channel, Lipids, Loss of Function Mutation, Models, Molecular, Molecular Docking Simulation, Molecular Dynamics Simulation, Protein Binding, Protein Conformation, Structure-Activity Relationship
Added March 21, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance.
Vanoye CG, Desai RR, Fabre KL, Gallagher SL, Potet F, DeKeyser JM, Macaya D, Meiler J, Sanders CR, George AL
(2018) Circ Genom Precis Med 11: e002345
MeSH Terms: Arrhythmias, Cardiac, Genetic Predisposition to Disease, Genotype, Humans, KCNQ1 Potassium Channel, Mutation
Added March 21, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations.
Huang H, Kuenze G, Smith JA, Taylor KC, Duran AM, Hadziselimovic A, Meiler J, Vanoye CG, George AL, Sanders CR
(2018) Sci Adv 4: eaar2631
MeSH Terms: Cell Membrane, HEK293 Cells, Humans, KCNQ1 Potassium Channel, Leupeptins, Long QT Syndrome, Loss of Function Mutation, Magnetic Resonance Spectroscopy, Mutant Proteins, Mutation, Proteasome Endopeptidase Complex, Proteasome Inhibitors, Protein Domains, Protein Folding, Protein Structure, Secondary, Proteolysis
Added March 14, 2018
0 Communities
3 Members
0 Resources
16 MeSH Terms
Exploiting ion channel structure to assess rare variant pathogenicity.
Kroncke BM, Yang T, Kannankeril P, Shoemaker MB, Roden DM
(2018) Heart Rhythm 15: 890-894
MeSH Terms: Adolescent, Adult, Body Surface Potential Mapping, DNA, DNA Mutational Analysis, ERG1 Potassium Channel, Female, Humans, KCNQ1 Potassium Channel, Long QT Syndrome, Mutation, Pedigree, Phenotype
Added March 26, 2019
0 Communities
3 Members
0 Resources
MeSH Terms
Predicting the Functional Impact of KCNQ1 Variants of Unknown Significance.
Li B, Mendenhall JL, Kroncke BM, Taylor KC, Huang H, Smith DK, Vanoye CG, Blume JD, George AL, Sanders CR, Meiler J
(2017) Circ Cardiovasc Genet 10:
MeSH Terms: Databases, Genetic, Female, Genetic Variation, Humans, KCNQ1 Potassium Channel, Long QT Syndrome, Male, Predictive Value of Tests, Protein Domains
Added March 14, 2018
0 Communities
4 Members
0 Resources
9 MeSH Terms
Azithromycin Causes a Novel Proarrhythmic Syndrome.
Yang Z, Prinsen JK, Bersell KR, Shen W, Yermalitskaya L, Sidorova T, Luis PB, Hall L, Zhang W, Du L, Milne G, Tucker P, George AL, Campbell CM, Pickett RA, Shaffer CM, Chopra N, Yang T, Knollmann BC, Roden DM, Murray KT
(2017) Circ Arrhythm Electrophysiol 10:
MeSH Terms: Action Potentials, Animals, Anti-Bacterial Agents, Arrhythmias, Cardiac, Azithromycin, CHO Cells, Calcium Channel Blockers, Calcium Channels, L-Type, Cricetulus, Dose-Response Relationship, Drug, Electrocardiography, Ambulatory, Female, HEK293 Cells, Heart Rate, Humans, KCNQ1 Potassium Channel, Mice, Inbred C57BL, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Potassium Channel Blockers, Potassium Channels, Inwardly Rectifying, Potassium Channels, Voltage-Gated, Rabbits, Sodium Channel Blockers, Telemetry, Time Factors, Transfection, Young Adult
Added July 6, 2017
0 Communities
2 Members
0 Resources
28 MeSH Terms
Regulation of KCNQ/Kv7 family voltage-gated K channels by lipids.
Taylor KC, Sanders CR
(2017) Biochim Biophys Acta Biomembr 1859: 586-597
MeSH Terms: Amino Acid Sequence, Binding Sites, Cell Membrane, Epilepsy, Benign Neonatal, Fatty Acids, Unsaturated, Hearing Loss, Bilateral, Humans, Hydrophobic and Hydrophilic Interactions, KCNQ1 Potassium Channel, Long QT Syndrome, Membrane Lipids, Models, Molecular, Phosphatidylinositol 4,5-Diphosphate, Protein Binding, Protein Isoforms, Protein Structure, Secondary
Added November 21, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting.
Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G
(2016) Nat Commun 7: 12795
MeSH Terms: Adamantane, Allosteric Regulation, Animals, Binding Sites, Cross-Linking Reagents, Humans, Ion Channel Gating, KCNQ1 Potassium Channel, Models, Molecular, Mutagenesis, Mutation, Oocytes, Potassium Channel Blockers, Potassium Channels, Voltage-Gated, Tandem Mass Spectrometry, Xenopus laevis
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Structural basis for KCNE3 modulation of potassium recycling in epithelia.
Kroncke BM, Van Horn WD, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Taylor KC, Sisco NJ, George AL, Meiler J, Vanoye CG, Sanders CR
(2016) Sci Adv 2: e1501228
MeSH Terms: Animals, Chloride Channels, Computational Biology, Cystic Fibrosis, Electrophysiological Phenomena, Epithelial Cells, Humans, KCNQ1 Potassium Channel, Multiprotein Complexes, Potassium, Potassium Channels, Voltage-Gated, Protein Domains
Added April 7, 2017
1 Communities
5 Members
0 Resources
12 MeSH Terms