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Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience.
Sanghani NS, Haase VH
(2019) Adv Chronic Kidney Dis 26: 253-266
MeSH Terms: Anemia, Barbiturates, Glycine, Humans, Isoquinolines, Picolinic Acids, Prolyl-Hydroxylase Inhibitors, Renal Insufficiency, Chronic, Treatment Outcome
Added March 24, 2020
0 Communities
1 Members
0 Resources
9 MeSH Terms
The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu PAM development candidate.
Panarese JD, Engers DW, Wu YJ, Guernon JM, Chun A, Gregro AR, Bender AM, Capstick RA, Wieting JM, Bronson JJ, Macor JE, Westphal R, Soars M, Engers JE, Felts AS, Rodriguez AL, Emmitte KA, Jones CK, Blobaum AL, Conn PJ, Niswender CM, Hopkins CR, Lindsley CW
(2019) Bioorg Med Chem Lett 29: 342-346
MeSH Terms: Allosteric Regulation, Dose-Response Relationship, Drug, Drug Discovery, Heterocyclic Compounds, 2-Ring, Humans, Isoquinolines, Molecular Structure, Myotonin-Protein Kinase, Receptors, Metabotropic Glutamate, Structure-Activity Relationship
Added March 3, 2020
0 Communities
2 Members
0 Resources
MeSH Terms
HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism.
Haase VH
(2017) Hemodial Int 21 Suppl 1: S110-S124
MeSH Terms: Anemia, Barbiturates, Clinical Trials as Topic, Erythropoiesis, Erythropoietin, Glycine, Humans, Hypoxia-Inducible Factor-Proline Dioxygenases, Iron, Isoquinolines, Picolinic Acids, Prolyl-Hydroxylase Inhibitors, Renal Dialysis
Added April 28, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
A small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants.
Huang H, Tao YX
(2014) Int J Biol Sci 10: 817-24
MeSH Terms: Flow Cytometry, HEK293 Cells, Humans, Microscopy, Confocal, Receptor, Melanocortin, Type 4, Tetrahydroisoquinolines, Triazoles
Added January 29, 2016
0 Communities
1 Members
0 Resources
7 MeSH Terms
Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.
Grohar PJ, Segars LE, Yeung C, Pommier Y, D'Incalci M, Mendoza A, Helman LJ
(2014) Clin Cancer Res 20: 1190-203
MeSH Terms: Animals, Antineoplastic Agents, Camptothecin, Cell Line, Tumor, DNA Breaks, Double-Stranded, DNA Damage, Dioxoles, Disease Models, Animal, Doxorubicin, Drug Resistance, Neoplasm, Drug Synergism, Exodeoxyribonucleases, Female, Gene Expression Regulation, Neoplastic, Gene Silencing, Humans, Irinotecan, Mice, Oncogene Proteins, Fusion, Phenotype, Proto-Oncogene Protein c-fli-1, RNA Interference, RNA, Small Interfering, RNA-Binding Protein EWS, RecQ Helicases, Sarcoma, Ewing, Tetrahydroisoquinolines, Trabectedin, Werner Syndrome Helicase, Xenograft Model Antitumor Assays
Added March 5, 2014
0 Communities
1 Members
0 Resources
30 MeSH Terms
Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroides.
Li F, Xia Y, Meiler J, Ferguson-Miller S
(2013) Biochemistry 52: 5884-99
MeSH Terms: Amino Acid Sequence, Apoptosis, Binding, Competitive, Carrier Proteins, Cholesterol, Cryoelectron Microscopy, Crystallization, Isoquinolines, Membrane Proteins, Mitochondrial Membranes, Protein Multimerization, Protoporphyrins, Receptors, GABA-A, Rhodobacter sphaeroides, Sequence Alignment
Added January 24, 2015
1 Communities
1 Members
0 Resources
15 MeSH Terms
Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species.
Samarakoon R, Dobberfuhl AD, Cooley C, Overstreet JM, Patel S, Goldschmeding R, Meldrum KK, Higgins PJ
(2013) Cell Signal 25: 2198-209
MeSH Terms: Animals, Benzothiazoles, Connective Tissue Growth Factor, Endothelium, Vascular, ErbB Receptors, Fibroblasts, Fibrosis, Gene Expression Regulation, Isoquinolines, Mice, Mink, Myocytes, Smooth Muscle, Pyridines, Pyrroles, Quinazolines, Rats, Reactive Oxygen Species, Renal Insufficiency, Chronic, Serpin E2, Signal Transduction, Smad2 Protein, Smad3 Protein, Toluene, Transforming Growth Factor beta1, Tumor Suppressor Protein p53, Tyrphostins
Added April 19, 2016
0 Communities
1 Members
0 Resources
26 MeSH Terms
Prospects and challenges for the development of new therapies for Ewing sarcoma.
Grohar PJ, Helman LJ
(2013) Pharmacol Ther 137: 216-24
MeSH Terms: Antineoplastic Agents, Bone Neoplasms, Camptothecin, Clinical Trials as Topic, Dioxoles, Epigenesis, Genetic, Humans, Molecular Targeted Therapy, Poly(ADP-ribose) Polymerase Inhibitors, Sarcoma, Ewing, Somatomedins, Tetrahydroisoquinolines, Trabectedin
Added September 3, 2013
0 Communities
2 Members
0 Resources
13 MeSH Terms
Preclinical molecular imaging of the translocator protein (TSPO) in a metastases model based on breast cancer xenografts propagated in the murine brain.
Wyatt SK, Manning HC, Bai M, Ehtesham M, Mapara KY, Thompson RC, Bornhop DJ
(2012) Curr Mol Med 12: 458-66
MeSH Terms: Adenocarcinoma, Animals, Brain, Brain Neoplasms, Breast Neoplasms, Carbocyanines, Cell Line, Tumor, Female, Humans, Isoquinolines, Mice, Mice, Nude, Molecular Imaging, Molecular Probes, Neoplasm Transplantation, Receptors, GABA, Tissue Distribution, Transplantation, Heterologous, Whole Body Imaging
Added March 5, 2014
0 Communities
2 Members
0 Resources
19 MeSH Terms
Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats.
Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA
(2011) Biol Psychiatry 70: 425-33
MeSH Terms: Amygdala, Animals, Anxiety, Conditioning, Psychological, Corpus Striatum, Disease Models, Animal, Dynorphins, Extinction, Psychological, Fear, Gene Expression Regulation, Hippocampus, Male, Maze Learning, Microinjections, Piperidines, Rats, Receptors, Opioid, kappa, Reflex, Startle, Signal Transduction, Tetrahydroisoquinolines
Added May 27, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms