The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu PAM development candidate.Panarese JD, Engers DW, Wu YJ, Guernon JM, Chun A, Gregro AR, Bender AM, Capstick RA, Wieting JM, Bronson JJ, Macor JE, Westphal R, Soars M, Engers JE, Felts AS, Rodriguez AL, Emmitte KA, Jones CK, Blobaum AL, Conn PJ, Niswender CM, Hopkins CR, Lindsley CW
(2019)
Bioorg Med Chem Lett 29: 342-346
MeSH Terms: Allosteric Regulation, Dose-Response Relationship, Drug, Drug Discovery, Heterocyclic Compounds, 2-Ring, Humans, Isoquinolines, Molecular Structure, Myotonin-Protein Kinase, Receptors, Metabotropic Glutamate, Structure-Activity RelationshipAdded March 3, 2020