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Results: 1 to 10 of 393

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Unicellular ancestry and mechanisms of diversification of Goodpasture antigen-binding protein.
Darris C, Revert F, Revert-Ros F, Gozalbo-Rovira R, Feigley A, Fidler A, Lopez-Pascual E, Saus J, Hudson BG
(2019) J Biol Chem 294: 759-769
MeSH Terms: Basement Membrane, Evolution, Molecular, Humans, Isoenzymes, Protein Serine-Threonine Kinases
Added November 19, 2018
0 Communities
1 Members
0 Resources
5 MeSH Terms
Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site.
Goodman MC, Xu S, Rouzer CA, Banerjee S, Ghebreselasie K, Migliore M, Piomelli D, Marnett LJ
(2018) J Biol Chem 293: 3028-3038
MeSH Terms: Amidohydrolases, Catalytic Domain, Cyclooxygenase Inhibitors, Isoenzymes, Phenylcarbamates, Phenylpropionates, Prostaglandin-Endoperoxide Synthases, Protein Binding, Stereoisomerism, Substrate Specificity
Added April 22, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates -retinol to 3,4-dehydroretinol.
Johnson KM, Phan TTN, Albertolle ME, Guengerich FP
(2017) J Biol Chem 292: 13672-13687
MeSH Terms: Biocatalysis, Cytochrome P450 Family 27, Diterpenes, Gene Expression Profiling, Gene Expression Regulation, Enzymologic, Humans, Hydrogenation, Hydroxylation, Isoenzymes, Kinetics, Mitochondria, Molecular Structure, Organ Specificity, Oxidation-Reduction, Peptide Fragments, Proteolysis, Proteomics, Skin, Stereoisomerism, Substrate Specificity, Vitamin A
Added March 14, 2018
0 Communities
1 Members
0 Resources
21 MeSH Terms
IL-17RC is critically required to maintain baseline A20 production to repress JNK isoform-dependent tumor-specific proliferation.
Yan C, Lei Y, Lin TJ, Hoskin DW, Ma A, Wang J
(2017) Oncotarget 8: 43153-43168
MeSH Terms: Animals, Cell Line, Tumor, Cell Proliferation, Female, Interleukin-17, Isoenzymes, MAP Kinase Kinase 4, Male, Mammary Neoplasms, Experimental, Melanoma, Melanoma, Experimental, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Receptors, Interleukin-17, Signal Transduction, Transcription Factors, Transfection, Tumor Necrosis Factor alpha-Induced Protein 3
Added May 15, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis.
Linton MF, Babaev VR, Huang J, Linton EF, Tao H, Yancey PG
(2016) Circ J 80: 2259-2268
MeSH Terms: Animals, Atherosclerosis, Endoplasmic Reticulum Stress, Humans, I-kappa B Kinase, Isoenzymes, Macrophages, Mechanistic Target of Rapamycin Complex 2, Mitogen-Activated Protein Kinase 8, Multiprotein Complexes, Proto-Oncogene Proteins c-akt, Signal Transduction, TOR Serine-Threonine Kinases, Unfolded Protein Response
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
NF-κB and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance.
Austin DC, Strand DW, Love HL, Franco OE, Grabowska MM, Miller NL, Hameed O, Clark PE, Matusik RJ, Jin RJ, Hayward SW
(2016) Prostate 76: 1004-18
MeSH Terms: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, 5-alpha Reductase Inhibitors, Animals, Apoptosis, Drug Resistance, Gene Expression, Gene Knockdown Techniques, Humans, Isoenzymes, Lower Urinary Tract Symptoms, Male, Membrane Proteins, Mice, Mice, Nude, NF-kappa B, Orchiectomy, Prostate, Prostatic Hyperplasia, Prostatic Neoplasms, Castration-Resistant, Receptors, Androgen, Testosterone, Treatment Failure, Up-Regulation
Added April 18, 2017
0 Communities
1 Members
0 Resources
23 MeSH Terms
Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2.
Jerrell RJ, Parekh A
(2016) Biomaterials 84: 119-129
MeSH Terms: Biomechanical Phenomena, Cell Line, Tumor, Cell Movement, Extracellular Matrix, Humans, Isoenzymes, Lim Kinases, Myosin Type II, Neoplasm Invasiveness, Phosphorylation, Pseudopodia, Signal Transduction, rho-Associated Kinases
Added February 23, 2016
1 Communities
1 Members
0 Resources
13 MeSH Terms
Introduction: Metals in Biology: α-Ketoglutarate/Iron-Dependent Dioxygenases.
Guengerich FP
(2015) J Biol Chem 290: 20700-20701
MeSH Terms: 5-Methylcytosine, AlkB Homolog 4, Lysine Demethylase, DNA, DNA Damage, DNA Repair, Dioxygenases, Epigenesis, Genetic, Gene Expression, Humans, Iron, Isoenzymes, Ketoglutaric Acids, Multigene Family, Oxidation-Reduction, Protein Processing, Post-Translational, Thymine
Added March 14, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms
Alkaline phosphatase protects lipopolysaccharide-induced early pregnancy defects in mice.
Lei W, Ni H, Herington J, Reese J, Paria BC
(2015) PLoS One 10: e0123243
MeSH Terms: Alkaline Phosphatase, Animals, Disease Models, Animal, Embryo Implantation, Enzyme Activation, Female, Gene Expression, In Situ Hybridization, Inflammation, Isoenzymes, Lipopolysaccharide Receptors, Lipopolysaccharides, Mice, Myeloid Differentiation Factor 88, Phosphorylation, Pregnancy, Pregnancy Complications, RNA, Messenger, Real-Time Polymerase Chain Reaction, Toll-Like Receptor 4, Uterus
Added May 26, 2015
0 Communities
2 Members
0 Resources
21 MeSH Terms
Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450.
Bojić M, Sedgeman CA, Nagy LD, Guengerich FP
(2015) Eur J Pharm Sci 73: 49-56
MeSH Terms: Aspirin, Benzaldehydes, Biotransformation, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Deferoxamine, Enzyme Inhibitors, Humans, Hydroxylation, Isoenzymes, Microsomes, Liver, NADP, Organophosphates, Oxidation-Reduction, Reactive Oxygen Species, Recombinant Proteins, Salicylic Acid
Added March 14, 2018
0 Communities
1 Members
0 Resources
17 MeSH Terms