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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 28

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Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus.
Harlow ML, Maloney N, Roland J, Guillen Navarro MJ, Easton MK, Kitchen-Goosen SM, Boguslawski EA, Madaj ZB, Johnson BK, Bowman MJ, D'Incalci M, Winn ME, Turner L, Hostetter G, Galmarini CM, Aviles PM, Grohar PJ
(2016) Cancer Res 76: 6657-6668
MeSH Terms: Animals, Camptothecin, Cell Line, Tumor, Female, Humans, Irinotecan, Mice, Mice, Nude, Oncogene Proteins, Oncogene Proteins, Fusion, Proto-Oncogene Protein c-fli-1, RNA-Binding Protein EWS, Sarcoma, Ewing
Added June 27, 2017
0 Communities
1 Members
0 Resources
13 MeSH Terms
Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.
Grohar PJ, Segars LE, Yeung C, Pommier Y, D'Incalci M, Mendoza A, Helman LJ
(2014) Clin Cancer Res 20: 1190-203
MeSH Terms: Animals, Antineoplastic Agents, Camptothecin, Cell Line, Tumor, DNA Breaks, Double-Stranded, DNA Damage, Dioxoles, Disease Models, Animal, Doxorubicin, Drug Resistance, Neoplasm, Drug Synergism, Exodeoxyribonucleases, Female, Gene Expression Regulation, Neoplastic, Gene Silencing, Humans, Irinotecan, Mice, Oncogene Proteins, Fusion, Phenotype, Proto-Oncogene Protein c-fli-1, RNA Interference, RNA, Small Interfering, RNA-Binding Protein EWS, RecQ Helicases, Sarcoma, Ewing, Tetrahydroisoquinolines, Trabectedin, Werner Syndrome Helicase, Xenograft Model Antitumor Assays
Added March 5, 2014
0 Communities
1 Members
0 Resources
30 MeSH Terms
Population pharmacokinetics of PEGylated liposomal CPT-11 (IHL-305) in patients with advanced solid tumors.
Wu H, Infante JR, Keedy VL, Jones SF, Chan E, Bendell JC, Lee W, Zamboni BA, Ikeda S, Kodaira H, Rothenberg ML, Burris HA, Zamboni WC
(2013) Eur J Clin Pharmacol 69: 2073-81
MeSH Terms: Adult, Aged, Antineoplastic Agents, Phytogenic, Camptothecin, Female, Humans, Infusions, Intravenous, Irinotecan, Liposomes, Male, Middle Aged, Models, Biological, Neoplasms, Polyethylene Glycols
Added March 7, 2014
0 Communities
2 Members
0 Resources
14 MeSH Terms
Aflibercept.
Ciombor KK, Berlin J, Chan E
(2013) Clin Cancer Res 19: 1920-5
MeSH Terms: Antineoplastic Combined Chemotherapy Protocols, Camptothecin, Clinical Trials, Phase II as Topic, Clinical Trials, Phase III as Topic, Colorectal Neoplasms, Disease-Free Survival, Fluorouracil, Humans, Irinotecan, Leucovorin, Neoplasm Metastasis, Organoplatinum Compounds, Oxaliplatin, Placenta Growth Factor, Pregnancy Proteins, Protein Binding, Randomized Controlled Trials as Topic, Receptors, Vascular Endothelial Growth Factor, Recombinant Fusion Proteins, Treatment Outcome, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor B
Added September 10, 2013
0 Communities
4 Members
0 Resources
22 MeSH Terms
Phase I and pharmacokinetic study of IHL-305 (PEGylated liposomal irinotecan) in patients with advanced solid tumors.
Infante JR, Keedy VL, Jones SF, Zamboni WC, Chan E, Bendell JC, Lee W, Wu H, Ikeda S, Kodaira H, Rothenberg ML, Burris HA
(2012) Cancer Chemother Pharmacol 70: 699-705
MeSH Terms: Adult, Aged, Antineoplastic Agents, Phytogenic, Camptothecin, Dose-Response Relationship, Drug, Female, Glucuronosyltransferase, Humans, Irinotecan, Liposomes, Male, Maximum Tolerated Dose, Middle Aged, Neoplasms, Polyethylene Glycols, Treatment Outcome
Added March 11, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Phase II 2-arm trial of the proteasome inhibitor, PS-341 (bortezomib) in combination with irinotecan or PS-341 alone followed by the addition of irinotecan at time of progression in patients with locally recurrent or metastatic squamous cell carcinoma of the head and neck (E1304): a trial of the Eastern Cooperative Oncology Group.
Gilbert J, Lee JW, Argiris A, Haigentz M, Feldman LE, Jang M, Arun P, Van Waes C, Forastiere AA
(2013) Head Neck 35: 942-8
MeSH Terms: Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Boronic Acids, Bortezomib, Camptothecin, Carcinoma, Squamous Cell, Cytokines, Disease Progression, Female, Head and Neck Neoplasms, Humans, Irinotecan, Male, Middle Aged, NF-kappa B, Pyrazines, Squamous Cell Carcinoma of Head and Neck, Treatment Outcome
Added March 5, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Evaluation of combined bevacizumab plus irinotecan therapy in brain tumors using magnetic resonance imaging measures of relative cerebral blood volume.
Pechman KR, Donohoe DL, Bedekar DP, Kurpad SN, Schmainda KM
(2012) Magn Reson Med 68: 1266-72
MeSH Terms: Animals, Antibodies, Monoclonal, Humanized, Antineoplastic Combined Chemotherapy Protocols, Bevacizumab, Blood Volume, Blood Volume Determination, Brain Neoplasms, Camptothecin, Cell Line, Tumor, Cerebrovascular Circulation, Irinotecan, Magnetic Resonance Imaging, Male, Rats, Rats, Nude, Reproducibility of Results, Sensitivity and Specificity, Treatment Outcome
Added March 6, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
A phase II study of carboplatin and irinotecan in extensive stage small-cell lung cancer.
Horn L, Zhao Z, Sandler A, Johnson D, Shyr Y, Wolff S, Devore RF, Laskin J
(2011) Clin Lung Cancer 12: 161-5
MeSH Terms: Antineoplastic Combined Chemotherapy Protocols, Camptothecin, Carboplatin, Female, Humans, Irinotecan, Lung Neoplasms, Male, Middle Aged, Neoplasm Staging, Small Cell Lung Carcinoma
Added February 13, 2014
0 Communities
2 Members
0 Resources
11 MeSH Terms
Phase I study of oral irinotecan as a single-agent and given sequentially with capecitabine.
Goff LW, Benson AB, LoRusso PM, Tan AR, Berlin JD, Denis LJ, Benner RJ, Yin D, Rothenberg ML
(2012) Invest New Drugs 30: 290-8
MeSH Terms: Administration, Oral, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Camptothecin, Capecitabine, Deoxycytidine, Drug Administration Schedule, Female, Fluorouracil, Humans, Irinotecan, Male, Maximum Tolerated Dose, Middle Aged, Neoplasms, Treatment Outcome
Added March 11, 2014
0 Communities
2 Members
0 Resources
18 MeSH Terms
A phase I trial of irinotecan alternating with epirubicin in patients with advanced malignancies.
Goff LW, Rothenberg ML, Lockhart AC, Roth BJ, VerMeulen WL, Chan E, Berlin JD
(2008) Am J Clin Oncol 31: 413-6
MeSH Terms: Aged, Antineoplastic Combined Chemotherapy Protocols, Camptothecin, Disease-Free Survival, Epirubicin, Female, Humans, Irinotecan, Male, Maximum Tolerated Dose, Middle Aged, Neoplasms, Salvage Therapy, Survival Rate, Treatment Outcome
Added March 11, 2014
0 Communities
3 Members
0 Resources
15 MeSH Terms