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Results: 1 to 10 of 64

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AMPA receptor structure and auxiliary subunits.
Kamalova A, Nakagawa T
(2021) J Physiol 599: 453-469
MeSH Terms: Animals, Glutamic Acid, Ion Channel Gating, Protein Subunits, Receptors, AMPA, Synapses, Synaptic Transmission
Added March 3, 2020
0 Communities
1 Members
0 Resources
7 MeSH Terms
Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.
Nakagawa T
(2019) Science 366: 1259-1263
MeSH Terms: Animals, Brain, Cryoelectron Microscopy, Glutamic Acid, Ion Channel Gating, Protein Structure, Secondary, Protein Transport, Rats, Receptors, AMPA, Receptors, Glutamate, Synaptic Transmission
Added March 3, 2020
0 Communities
1 Members
0 Resources
11 MeSH Terms
Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063.
Kharade SV, Sanchez-Andres JV, Fulton MG, Shelton EL, Blobaum AL, Engers DW, Hofmann CS, Dadi PK, Lantier L, Jacobson DA, Lindsley CW, Denton JS
(2019) J Pharmacol Exp Ther 370: 350-359
MeSH Terms: Animals, Ductus Arteriosus, Glucose, HEK293 Cells, Humans, Insulin Secretion, Insulin-Secreting Cells, Ion Channel Gating, Mice, Potassium Channels, Inwardly Rectifying, Structure-Activity Relationship, Sulfonylurea Receptors, Vasodilation, Xanthines
Added June 14, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating.
Sierra-Valdez F, Azumaya CM, Romero LO, Nakagawa T, Cordero-Morales JF
(2018) J Biol Chem 293: 16102-16114
MeSH Terms: Allosteric Regulation, Ankyrin Repeat, HEK293 Cells, Humans, Ion Channel Gating, Mutation, Protein Conformation, alpha-Helical, Protein Domains, TRPC Cation Channels
Added April 10, 2019
0 Communities
1 Members
0 Resources
9 MeSH Terms
Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels.
Kozek KA, Du Y, Sharma S, Prael FJ, Spitznagel BD, Kharade SV, Denton JS, Hopkins CR, Weaver CD
(2019) ACS Chem Neurosci 10: 358-370
MeSH Terms: Dose-Response Relationship, Drug, Drug Discovery, G Protein-Coupled Inwardly-Rectifying Potassium Channels, HEK293 Cells, Humans, Ion Channel Gating, Neurons, Pyrazines
Added April 10, 2019
0 Communities
1 Members
0 Resources
8 MeSH Terms
Modulation of ClC-3 gating and proton/anion exchange by internal and external protons and the anion selectivity filter.
Rohrbough J, Nguyen HN, Lamb FS
(2018) J Physiol 596: 4091-4119
MeSH Terms: Anions, Cell Membrane, Chloride Channels, Glutamic Acid, HEK293 Cells, Humans, Hydrogen-Ion Concentration, Ion Channel Gating, Ion Transport, Kinetics, Mutation, Protons, Tyrosine
Added March 26, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Engineering defined membrane-embedded elements of AMPA receptor induces opposing gating modulation by cornichon 3 and stargazin.
Hawken NM, Zaika EI, Nakagawa T
(2017) J Physiol 595: 6517-6539
MeSH Terms: Calcium Channels, Cell Line, Cell Membrane, Humans, Ion Channel Gating, Mutation, Protein Domains, Receptors, AMPA
Added March 21, 2018
0 Communities
1 Members
0 Resources
8 MeSH Terms
Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome.
Anderson LL, Hawkins NA, Thompson CH, Kearney JA, George AL
(2017) Sci Rep 7: 1682
MeSH Terms: Action Potentials, Animals, Epilepsies, Myoclonic, Ion Channel Gating, Mice, Inbred C57BL, Mice, Knockout, NAV1.1 Voltage-Gated Sodium Channel, NAV1.6 Voltage-Gated Sodium Channel, Neurons, Pyramidal Cells, Pyridines, Seizures, Survival Analysis, Triazoles
Added October 2, 2018
1 Communities
0 Members
0 Resources
14 MeSH Terms
Densin-180 Controls the Trafficking and Signaling of L-Type Voltage-Gated Ca1.2 Ca Channels at Excitatory Synapses.
Wang S, Stanika RI, Wang X, Hagen J, Kennedy MB, Obermair GJ, Colbran RJ, Lee A
(2017) J Neurosci 37: 4679-4691
MeSH Terms: Animals, Calcium Channels, L-Type, Calcium Signaling, Cerebral Cortex, Excitatory Postsynaptic Potentials, Ion Channel Gating, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Neurons, Protein Transport, Sialoglycoproteins, Signal Transduction, Synapses
Added April 26, 2017
0 Communities
1 Members
0 Resources
15 MeSH Terms
KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting.
Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G
(2016) Nat Commun 7: 12795
MeSH Terms: Adamantane, Allosteric Regulation, Animals, Binding Sites, Cross-Linking Reagents, Humans, Ion Channel Gating, KCNQ1 Potassium Channel, Models, Molecular, Mutagenesis, Mutation, Oocytes, Potassium Channel Blockers, Potassium Channels, Voltage-Gated, Tandem Mass Spectrometry, Xenopus laevis
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms