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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 1 to 10 of 17

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Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.
Yu G, Tzouvelekis A, Wang R, Herazo-Maya JD, Ibarra GH, Srivastava A, de Castro JPW, DeIuliis G, Ahangari F, Woolard T, Aurelien N, Arrojo E Drigo R, Gan Y, Graham M, Liu X, Homer RJ, Scanlan TS, Mannam P, Lee PJ, Herzog EL, Bianco AC, Kaminski N
(2018) Nat Med 24: 39-49
MeSH Terms: Animals, Cells, Cultured, Epithelium, Female, Humans, Iodide Peroxidase, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitochondria, Molecular Mimicry, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Protein Kinases, Pulmonary Fibrosis, Thyroid Hormones
Added April 14, 2021
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MeSH Terms
The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex.
Arrojo E Drigo R, Egri P, Jo S, Gereben B, Bianco AC
(2013) Mol Endocrinol 27: 2105-15
MeSH Terms: Adenosine Triphosphatases, Ataxin-3, Cytoplasm, Endoplasmic Reticulum, Endoplasmic Reticulum-Associated Degradation, Enzyme Stability, HEK293 Cells, Humans, Iodide Peroxidase, Lysine, Nerve Tissue Proteins, Nuclear Proteins, Proteasome Endopeptidase Complex, Protein Transport, Repressor Proteins, Substrate Specificity, Ubiquitin, Ubiquitination
Added April 14, 2021
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MeSH Terms
Coordination of hypothalamic and pituitary T3 production regulates TSH expression.
Fonseca TL, Correa-Medina M, Campos MP, Wittmann G, Werneck-de-Castro JP, Arrojo e Drigo R, Mora-Garzon M, Ueta CB, Caicedo A, Fekete C, Gereben B, Lechan RM, Bianco AC
(2013) J Clin Invest 123: 1492-500
MeSH Terms: Animals, Astrocytes, Body Composition, Cerebral Cortex, Enzyme Activation, Feedback, Physiological, Gene Expression Regulation, Glial Fibrillary Acidic Protein, Hippocampus, Hypothalamus, Iodide Peroxidase, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Organ Specificity, Pituitary Gland, Thyroid Gland, Thyrotrophs, Thyrotropin, Thyrotropin-Releasing Hormone, Thyroxine, Triiodothyronine
Added April 14, 2021
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Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls.
Liao KP, Kurreeman F, Li G, Duclos G, Murphy S, Guzman R, Cai T, Gupta N, Gainer V, Schur P, Cui J, Denny JC, Szolovits P, Churchill S, Kohane I, Karlson EW, Plenge RM
(2013) Arthritis Rheum 65: 571-81
MeSH Terms: Aged, Antibodies, Antinuclear, Arthritis, Rheumatoid, Autoantibodies, Electronic Health Records, Female, GTP-Binding Proteins, Genetic Predisposition to Disease, Genotype, Humans, Hypothyroidism, Iodide Peroxidase, Male, Middle Aged, Peptides, Cyclic, Protein Glutamine gamma Glutamyltransferase 2, Risk Factors, Seroepidemiologic Studies, Sjogren's Syndrome, Thyroiditis, Transglutaminases, Whites
Added May 27, 2014
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22 MeSH Terms
Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling.
Arrojo E Drigo R, Fonseca TL, Werneck-de-Castro JP, Bianco AC
(2013) Biochim Biophys Acta 1830: 3956-64
MeSH Terms: Animals, Gene Expression Regulation, Developmental, Humans, Iodide Peroxidase, Signal Transduction, Thyroid Hormones
Added April 14, 2021
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MeSH Terms
Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.
Jo S, Kalló I, Bardóczi Z, Arrojo e Drigo R, Zeöld A, Liposits Z, Oliva A, Lemmon VP, Bixby JL, Gereben B, Bianco AC
(2012) J Neurosci 32: 8491-500
MeSH Terms: Animals, Brain Ischemia, Cell Hypoxia, Cell Nucleus, Cells, Cultured, DNA, Endoplasmic Reticulum, Glycosylation, HSP40 Heat-Shock Proteins, Hippocampus, Immunohistochemistry, Immunoprecipitation, Iodide Peroxidase, Male, Microscopy, Electron, Middle Cerebral Artery, Neurons, Oxygen Consumption, Polymerase Chain Reaction, Rats, Rats, Sprague-Dawley, Receptors, Thyroid Hormone, Signal Transduction, Thyroid Hormones
Added April 14, 2021
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MeSH Terms
Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis.
Arrojo E Drigo R, Fonseca TL, Castillo M, Salathe M, Simovic G, Mohácsik P, Gereben B, Bianco AC
(2011) Mol Endocrinol 25: 2065-75
MeSH Terms: Animals, Cell Line, Cystic Fibrosis, Down-Regulation, Endoplasmic Reticulum Stress, Epithelial Cells, Eukaryotic Initiation Factor-2, Gene Expression, Humans, Iodide Peroxidase, Mice, Proteasome Endopeptidase Complex, Protein Stability, Proteolysis, Respiratory Mucosa, Signal Transduction, Thapsigargin, Thyroxine, Transcription Factor CHOP, Triiodothyronine, Tunicamycin
Added April 14, 2021
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MeSH Terms
Type 2 deiodinase at the crossroads of thyroid hormone action.
Arrojo E Drigo R, Bianco AC
(2011) Int J Biochem Cell Biol 43: 1432-41
MeSH Terms: Animals, Gene Expression Regulation, Developmental, Humans, Iodide Peroxidase, Mice, Proteasome Endopeptidase Complex, Signal Transduction, Thyroxine, Tissue Distribution, Triiodothyronine, Ubiquitin Thiolesterase, Ubiquitin-Protein Ligases, Ubiquitination
Added April 14, 2021
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The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.
da-Silva WS, Ribich S, Arrojo e Drigo R, Castillo M, Patti ME, Bianco AC
(2011) FEBS Lett 585: 539-44
MeSH Terms: Adipocytes, Brown, Animals, Cell Line, Cells, Cultured, Dietary Fats, Energy Metabolism, Gene Expression Regulation, Gene Knockout Techniques, Glucose Intolerance, Humans, Iodide Peroxidase, Lipid Metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Oxygen Consumption, Phenylbutyrates, RNA, Messenger, Taurochenodeoxycholic Acid, Triiodothyronine
Added April 14, 2021
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MeSH Terms
Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment.
Rosene ML, Wittmann G, Arrojo e Drigo R, Singru PS, Lechan RM, Bianco AC
(2010) Endocrinology 151: 5961-70
MeSH Terms: Amiodarone, Animals, Anti-Arrhythmia Agents, Cell Line, Iodide Peroxidase, Mice, Mice, Inbred C57BL, Mice, Knockout, Thyrotropin
Added April 14, 2021
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MeSH Terms