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Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4 T cells.
Hoek KL, Greer MJ, McClanahan KG, Nazmi A, Piazuelo MB, Singh K, Wilson KT, Olivares-Villagómez D
(2021) Mucosal Immunol 14: 1088-1099
MeSH Terms: Animals, Biomarkers, CD4-Positive T-Lymphocytes, Cell Differentiation, Cell Transplantation, Cytokines, Disease Susceptibility, Female, Gene Expression Profiling, Gene Expression Regulation, Granzymes, Immune Reconstitution, Immunophenotyping, Interleukin-17, Intraepithelial Lymphocytes, Lymphocyte Activation, Male, Mice, Mice, Knockout, Mice, Transgenic, T-Lymphocyte Subsets, T-Lymphocytes, Helper-Inducer
Added July 1, 2021
0 Communities
1 Members
0 Resources
22 MeSH Terms
Elevated mucus interleukin-17A levels are associated with increased prior sinus surgery for chronic rhinosinusitis.
Chapurin N, Li P, Chandra RK, Turner JH, Chowdhury NI
(2021) Int Forum Allergy Rhinol 11: 120-127
MeSH Terms: Chronic Disease, Cross-Sectional Studies, Cytokines, Humans, Interleukin-17, Mucus, Retrospective Studies, Rhinitis
Added September 23, 2020
0 Communities
1 Members
0 Resources
8 MeSH Terms
Early Surgical Management of Thermal Airway Injury: A Case Series.
Jayawardena A, Lowery AS, Wootten C, Dion GR, Summitt JB, McGrane S, Gelbard A
(2019) J Burn Care Res 40: 189-195
MeSH Terms: Adrenal Cortex Hormones, Adult, Anti-Bacterial Agents, Azithromycin, Burns, Inhalation, Cicatrix, Humans, Immunity, Mucosal, Interleukin-17, Laryngoscopy, Male, Reconstructive Surgical Procedures, Skin Transplantation, Stents, Tracheostomy
Added July 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Pathologic Fibroblasts in Idiopathic Subglottic Stenosis Amplify Local Inflammatory Signals.
Morrison RJ, Katsantonis NG, Motz KM, Hillel AT, Garrett CG, Netterville JL, Wootten CT, Majka SM, Blackwell TS, Drake WP, Gelbard A
(2019) Otolaryngol Head Neck Surg 160: 107-115
MeSH Terms: Biopsy, Needle, Case-Control Studies, Cell Proliferation, Cells, Cultured, Cicatrix, Cytokines, Enzyme-Linked Immunosorbent Assay, Female, Fibroblasts, Fibrosis, Flow Cytometry, Humans, Immunohistochemistry, Interleukin-17, Laryngostenosis, Male, Polymerase Chain Reaction, Reference Values, Sensitivity and Specificity, Signal Transduction
Added July 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
PD-1 up-regulation on CD4 T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production.
Celada LJ, Kropski JA, Herazo-Maya JD, Luo W, Creecy A, Abad AT, Chioma OS, Lee G, Hassell NE, Shaginurova GI, Wang Y, Johnson JE, Kerrigan A, Mason WR, Baughman RP, Ayers GD, Bernard GR, Culver DA, Montgomery CG, Maher TM, Molyneaux PL, Noth I, Mutsaers SE, Prele CM, Peebles RS, Newcomb DC, Kaminski N, Blackwell TS, Van Kaer L, Drake WP
(2018) Sci Transl Med 10:
MeSH Terms: Adult, Aged, Animals, Bleomycin, CD4-Positive T-Lymphocytes, Cell Proliferation, Collagen Type I, Disease Models, Animal, Female, Fibroblasts, Gene Expression Regulation, Humans, Idiopathic Pulmonary Fibrosis, Interleukin-17, Male, Mice, Middle Aged, Programmed Cell Death 1 Receptor, RNA, Messenger, STAT3 Transcription Factor, Sarcoidosis, Th17 Cells, Transforming Growth Factor beta1, Up-Regulation
Added March 26, 2019
0 Communities
1 Members
0 Resources
24 MeSH Terms
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.
Dejea CM, Fathi P, Craig JM, Boleij A, Taddese R, Geis AL, Wu X, DeStefano Shields CE, Hechenbleikner EM, Huso DL, Anders RA, Giardiello FM, Wick EC, Wang H, Wu S, Pardoll DM, Housseau F, Sears CL
(2018) Science 359: 592-597
MeSH Terms: Adenomatous Polyposis Coli, Animals, Bacterial Toxins, Bacteroides fragilis, Biofilms, Carcinogenesis, Colon, Colonic Neoplasms, DNA Damage, Escherichia coli, Gastrointestinal Microbiome, Humans, Interleukin-17, Intestinal Mucosa, Metalloendopeptidases, Mice, Peptides, Polyketides, Precancerous Conditions
Added March 20, 2018
0 Communities
1 Members
0 Resources
19 MeSH Terms
Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.
Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F
(2018) Cell Host Microbe 23: 203-214.e5
MeSH Terms: Adenomatous Polyposis Coli Protein, Animals, Bacterial Toxins, Bacteroides fragilis, Carcinogenesis, Cell Line, Tumor, Colon, Colorectal Neoplasms, Enzyme Activation, Epithelial Cells, Female, Gene Deletion, HT29 Cells, Humans, Inflammation, Interleukin-17, Male, Metalloendopeptidases, Mice, Mice, Inbred C57BL, Mice, Knockout, Myeloid Cells, Receptors, Interleukin-17, Receptors, Interleukin-8B, STAT3 Transcription Factor, Transcription Factor RelA
Added March 20, 2018
0 Communities
1 Members
0 Resources
26 MeSH Terms
IL-17RC is critically required to maintain baseline A20 production to repress JNK isoform-dependent tumor-specific proliferation.
Yan C, Lei Y, Lin TJ, Hoskin DW, Ma A, Wang J
(2017) Oncotarget 8: 43153-43168
MeSH Terms: Animals, Cell Line, Tumor, Cell Proliferation, Female, Interleukin-17, Isoenzymes, MAP Kinase Kinase 4, Male, Mammary Neoplasms, Experimental, Melanoma, Melanoma, Experimental, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Receptors, Interleukin-17, Signal Transduction, Transcription Factors, Transfection, Tumor Necrosis Factor alpha-Induced Protein 3
Added May 15, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients.
Rosen MJ, Karns R, Vallance JE, Bezold R, Waddell A, Collins MH, Haberman Y, Minar P, Baldassano RN, Hyams JS, Baker SS, Kellermayer R, Noe JD, Griffiths AM, Rosh JR, Crandall WV, Heyman MB, Mack DR, Kappelman MD, Markowitz J, Moulton DE, Leleiko NS, Walters TD, Kugathasan S, Wilson KT, Hogan SP, Denson LA
(2017) Gastroenterology 152: 1345-1357.e7
MeSH Terms: Adolescent, Area Under Curve, Case-Control Studies, Child, Colitis, Ulcerative, Colon, Crohn Disease, Female, Gene Expression, Humans, Immunity, Mucosal, Interleukin-13, Interleukin-13 Receptor alpha2 Subunit, Interleukin-17, Interleukin-23, Interleukin-5, Interleukins, Intestinal Mucosa, Male, Predictive Value of Tests, Prognosis, Prospective Studies, RNA, Messenger, ROC Curve, Rectum, Transcriptome, Up-Regulation
Added January 31, 2017
0 Communities
1 Members
0 Resources
27 MeSH Terms
TLR9 activation suppresses inflammation in response to Helicobacter pylori infection.
Varga MG, Piazuelo MB, Romero-Gallo J, Delgado AG, Suarez G, Whitaker ME, Krishna US, Patel RV, Skaar EP, Wilson KT, Algood HM, Peek RM
(2016) Am J Physiol Gastrointest Liver Physiol 311: G852-G858
MeSH Terms: Animals, Gastric Mucosa, Helicobacter Infections, Helicobacter pylori, Inflammation, Interleukin-17, Mice, Mice, Knockout, Toll-Like Receptor 9
Added October 22, 2016
0 Communities
4 Members
0 Resources
9 MeSH Terms